A molecular mechanism for bright color variation in parrots.
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PubMed
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| Auteurs principaux: | , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Artículo científico |
| Langue: | en |
| Publié: |
Science (New York, N.Y.)
2024
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| _version_ | 1868266284966215682 |
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| author | Arbore, Roberto Barbosa, Soraia Brejcha, Jindřich Ogawa, Yohey Liu, Yu Nicolaï, Michaël P J Pereira, Paulo Sabatino, Stephen J Cloutier, Alison Poon, Emily Shui Kei Marques, Cristiana I Andrade, Pedro Debruyn, Gerben Afonso, Sandra Afonso, Rita Roy, Shatadru Ghosh Abdu, Uri Lopes, Ricardo J Mojzeš, Peter Maršík, Petr Sin, Simon Yung Wa White, Michael A Araújo, Pedro M Corbo, Joseph C Carneiro, Miguel |
| author_facet | Arbore, Roberto Barbosa, Soraia Brejcha, Jindřich Ogawa, Yohey Liu, Yu Nicolaï, Michaël P J Pereira, Paulo Sabatino, Stephen J Cloutier, Alison Poon, Emily Shui Kei Marques, Cristiana I Andrade, Pedro Debruyn, Gerben Afonso, Sandra Afonso, Rita Roy, Shatadru Ghosh Abdu, Uri Lopes, Ricardo J Mojzeš, Peter Maršík, Petr Sin, Simon Yung Wa White, Michael A Araújo, Pedro M Corbo, Joseph C Carneiro, Miguel Arbore, Roberto Barbosa, Soraia Brejcha, Jindřich Ogawa, Yohey Liu, Yu Nicolaï, Michaël P J Pereira, Paulo Sabatino, Stephen J Cloutier, Alison Poon, Emily Shui Kei Marques, Cristiana I Andrade, Pedro Debruyn, Gerben Afonso, Sandra Afonso, Rita Roy, Shatadru Ghosh Abdu, Uri Lopes, Ricardo J Mojzeš, Peter Maršík, Petr Sin, Simon Yung Wa White, Michael A Araújo, Pedro M Corbo, Joseph C Carneiro, Miguel |
| collection | PubMed - marine biology |
| contents | A molecular mechanism for bright color variation in parrots. Arbore, Roberto Barbosa, Soraia Brejcha, Jindřich Ogawa, Yohey Liu, Yu Nicolaï, Michaël P J Pereira, Paulo Sabatino, Stephen J Cloutier, Alison Poon, Emily Shui Kei Marques, Cristiana I Andrade, Pedro Debruyn, Gerben Afonso, Sandra Afonso, Rita Roy, Shatadru Ghosh Abdu, Uri Lopes, Ricardo J Mojzeš, Peter Maršík, Petr Sin, Simon Yung Wa White, Michael A Araújo, Pedro M Corbo, Joseph C Carneiro, Miguel Animals Aldehyde Dehydrogenase Color Feathers Keratinocytes Oxidation-Reduction Parrots Pigmentation Pigments, Biological Aldehyde Oxidoreductases Parrots produce stunning plumage colors through unique pigments called psittacofulvins. However, the mechanism underlying their ability to generate a spectrum of vibrant yellows, reds, and greens remains enigmatic. We uncover a unifying chemical basis for a wide range of parrot plumage colors, which result from the selective deposition of red aldehyde- and yellow carboxyl-containing psittacofulvin molecules in developing feathers. Through genetic mapping, biochemical assays, and single-cell genomics, we identified a critical player in this process, the aldehyde dehydrogenase , which oxidizes aldehyde psittacofulvins into carboxyl forms in late-differentiating keratinocytes during feather development. The simplicity of the underlying molecular mechanism, in which a single enzyme influences the balance of red and yellow pigments, offers an explanation for the exceptional evolutionary lability of parrot coloration. |
| format | Artículo científico |
| id | pubmed_39480920 |
| institution | PubMed |
| language | en |
| publishDate | 2024 |
| publisher | Science (New York, N.Y.) |
| record_format | pubmed |
| spellingShingle | A molecular mechanism for bright color variation in parrots. Arbore, Roberto Barbosa, Soraia Brejcha, Jindřich Ogawa, Yohey Liu, Yu Nicolaï, Michaël P J Pereira, Paulo Sabatino, Stephen J Cloutier, Alison Poon, Emily Shui Kei Marques, Cristiana I Andrade, Pedro Debruyn, Gerben Afonso, Sandra Afonso, Rita Roy, Shatadru Ghosh Abdu, Uri Lopes, Ricardo J Mojzeš, Peter Maršík, Petr Sin, Simon Yung Wa White, Michael A Araújo, Pedro M Corbo, Joseph C Carneiro, Miguel Animals Aldehyde Dehydrogenase Color Feathers Keratinocytes Oxidation-Reduction Parrots Pigmentation Pigments, Biological Aldehyde Oxidoreductases A molecular mechanism for bright color variation in parrots. Arbore, Roberto Barbosa, Soraia Brejcha, Jindřich Ogawa, Yohey Liu, Yu Nicolaï, Michaël P J Pereira, Paulo Sabatino, Stephen J Cloutier, Alison Poon, Emily Shui Kei Marques, Cristiana I Andrade, Pedro Debruyn, Gerben Afonso, Sandra Afonso, Rita Roy, Shatadru Ghosh Abdu, Uri Lopes, Ricardo J Mojzeš, Peter Maršík, Petr Sin, Simon Yung Wa White, Michael A Araújo, Pedro M Corbo, Joseph C Carneiro, Miguel Animals Aldehyde Dehydrogenase Color Feathers Keratinocytes Oxidation-Reduction Parrots Pigmentation Pigments, Biological Aldehyde Oxidoreductases Parrots produce stunning plumage colors through unique pigments called psittacofulvins. However, the mechanism underlying their ability to generate a spectrum of vibrant yellows, reds, and greens remains enigmatic. We uncover a unifying chemical basis for a wide range of parrot plumage colors, which result from the selective deposition of red aldehyde- and yellow carboxyl-containing psittacofulvin molecules in developing feathers. Through genetic mapping, biochemical assays, and single-cell genomics, we identified a critical player in this process, the aldehyde dehydrogenase , which oxidizes aldehyde psittacofulvins into carboxyl forms in late-differentiating keratinocytes during feather development. The simplicity of the underlying molecular mechanism, in which a single enzyme influences the balance of red and yellow pigments, offers an explanation for the exceptional evolutionary lability of parrot coloration. |
| title | A molecular mechanism for bright color variation in parrots. |
| topic | Animals Aldehyde Dehydrogenase Color Feathers Keratinocytes Oxidation-Reduction Parrots Pigmentation Pigments, Biological Aldehyde Oxidoreductases |
| url | https://pubmed.ncbi.nlm.nih.gov/39480920/ |