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| Format: | Artículo científico |
| Sprache: | en |
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Carbohydrate polymers
2025
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| Online-Zugang: | https://pubmed.ncbi.nlm.nih.gov/39486979/ |
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| _version_ | 1868266284968312833 |
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| author | Wang, Pu Zhang, Qinling Wang, Shuxin Wang, Donghui Yip, Ryan Chak Sang Xie, Weidong Chen, Hao |
| author_facet | Wang, Pu Zhang, Qinling Wang, Shuxin Wang, Donghui Yip, Ryan Chak Sang Xie, Weidong Chen, Hao Wang, Pu Zhang, Qinling Wang, Shuxin Wang, Donghui Yip, Ryan Chak Sang Xie, Weidong Chen, Hao |
| collection | PubMed - marine biology |
| contents | Injectable Salecan/hyaluronic acid-based hydrogels with antibacterial, rapid self-healing, pH-responsive and controllable drug release capability for infected wound repair. Wang, Pu Zhang, Qinling Wang, Shuxin Wang, Donghui Yip, Ryan Chak Sang Xie, Weidong Chen, Hao Hyaluronic Acid Hydrogels Wound Healing Staphylococcus aureus Anti-Bacterial Agents Animals Escherichia coli Hydrogen-Ion Concentration Drug Liberation Mice Wound Infection Delayed-Action Preparations Injections Male Humans Biguanides Rats, Sprague-Dawley Bandages beta-Glucans Designing materials for wound dressings with superior therapeutic benefits, self-healing and injectable characteristics is important in clinical practice. Herein, a new self-healing injectable hydrogel was prepared via thermal treatment and dynamic Schiff base reaction by mixing oxidized hyaluronic acid (OHA) and hydrazided Salecan (Sal-ADH). The versatility of the wound dressing was confirmed by studying the inherent rheological properties, high swelling rate, sustained-release behavior of the drug, pH/hyaluronidase-dependent biodegradation, in vitro antimicrobial as well as in vivo wound healing performance. The presence of the antimicrobial drug polyhexamethylene biguanide (PHMB) conferred good antimicrobial properties to the Sal-ADH/OHA/PHMB (SOP) hydrogel, which could effectively prevent wound infection (the width of the inhibition circle of SOP-0.20 hydrogel was 4.97 mm, 5.93 mm for Staphylococcus aureus and Escherichia coli, respectively). The findings suggested that SOP hydrogel exhibited remarkable self-healing and injectability properties, as well as excellent hemostasis and biocompatibility. In vivo experiments indicated that the application of SOP hydrogels would obviously accelerate wound healing and attenuate the inflammatory response while increasing collagen deposition and angiogenesis. Altogether, antibacterial SOP hydrogels with moderate mechanical properties, pH-responsive release, excellent injectability, exceptional self-healing ability and anti-inflammatory effects could expand potential applications of injectable hydrogels in the biomedical field. |
| format | Artículo científico |
| id | pubmed_39486979 |
| institution | PubMed |
| language | en |
| publishDate | 2025 |
| publisher | Carbohydrate polymers |
| record_format | pubmed |
| spellingShingle | Injectable Salecan/hyaluronic acid-based hydrogels with antibacterial, rapid self-healing, pH-responsive and controllable drug release capability for infected wound repair. Wang, Pu Zhang, Qinling Wang, Shuxin Wang, Donghui Yip, Ryan Chak Sang Xie, Weidong Chen, Hao Hyaluronic Acid Hydrogels Wound Healing Staphylococcus aureus Anti-Bacterial Agents Animals Escherichia coli Hydrogen-Ion Concentration Drug Liberation Mice Wound Infection Delayed-Action Preparations Injections Male Humans Biguanides Rats, Sprague-Dawley Bandages beta-Glucans Injectable Salecan/hyaluronic acid-based hydrogels with antibacterial, rapid self-healing, pH-responsive and controllable drug release capability for infected wound repair. Wang, Pu Zhang, Qinling Wang, Shuxin Wang, Donghui Yip, Ryan Chak Sang Xie, Weidong Chen, Hao Hyaluronic Acid Hydrogels Wound Healing Staphylococcus aureus Anti-Bacterial Agents Animals Escherichia coli Hydrogen-Ion Concentration Drug Liberation Mice Wound Infection Delayed-Action Preparations Injections Male Humans Biguanides Rats, Sprague-Dawley Bandages beta-Glucans Designing materials for wound dressings with superior therapeutic benefits, self-healing and injectable characteristics is important in clinical practice. Herein, a new self-healing injectable hydrogel was prepared via thermal treatment and dynamic Schiff base reaction by mixing oxidized hyaluronic acid (OHA) and hydrazided Salecan (Sal-ADH). The versatility of the wound dressing was confirmed by studying the inherent rheological properties, high swelling rate, sustained-release behavior of the drug, pH/hyaluronidase-dependent biodegradation, in vitro antimicrobial as well as in vivo wound healing performance. The presence of the antimicrobial drug polyhexamethylene biguanide (PHMB) conferred good antimicrobial properties to the Sal-ADH/OHA/PHMB (SOP) hydrogel, which could effectively prevent wound infection (the width of the inhibition circle of SOP-0.20 hydrogel was 4.97 mm, 5.93 mm for Staphylococcus aureus and Escherichia coli, respectively). The findings suggested that SOP hydrogel exhibited remarkable self-healing and injectability properties, as well as excellent hemostasis and biocompatibility. In vivo experiments indicated that the application of SOP hydrogels would obviously accelerate wound healing and attenuate the inflammatory response while increasing collagen deposition and angiogenesis. Altogether, antibacterial SOP hydrogels with moderate mechanical properties, pH-responsive release, excellent injectability, exceptional self-healing ability and anti-inflammatory effects could expand potential applications of injectable hydrogels in the biomedical field. |
| title | Injectable Salecan/hyaluronic acid-based hydrogels with antibacterial, rapid self-healing, pH-responsive and controllable drug release capability for infected wound repair. |
| topic | Hyaluronic Acid Hydrogels Wound Healing Staphylococcus aureus Anti-Bacterial Agents Animals Escherichia coli Hydrogen-Ion Concentration Drug Liberation Mice Wound Infection Delayed-Action Preparations Injections Male Humans Biguanides Rats, Sprague-Dawley Bandages beta-Glucans |
| url | https://pubmed.ncbi.nlm.nih.gov/39486979/ |