Chemical proteomics accelerates the target discovery of natural products.
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| Autores principales: | , , , , , |
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| Formato: | Artículo científico |
| Lenguaje: | en |
| Publicado: |
Biochemical pharmacology
2024
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| Acceso en línea: | |
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| _version_ | 1868266282469556225 |
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| author | He, Shu-Jie Li, Jun Zhou, Jie-Chun Yang, Zhi-You Liu, Xi Ge, Yue-Wei |
| author_facet | He, Shu-Jie Li, Jun Zhou, Jie-Chun Yang, Zhi-You Liu, Xi Ge, Yue-Wei He, Shu-Jie Li, Jun Zhou, Jie-Chun Yang, Zhi-You Liu, Xi Ge, Yue-Wei |
| collection | PubMed - marine biology |
| contents | Chemical proteomics accelerates the target discovery of natural products. He, Shu-Jie Li, Jun Zhou, Jie-Chun Yang, Zhi-You Liu, Xi Ge, Yue-Wei Biological Products Proteomics Humans Drug Discovery Animals More than half of the global novel drugs are directly or indirectly derived from natural products (NPs) because of their better selectivity towards proteins. Traditional medicines perform multiple bioactivities through various NPs binding to drug targets, which highlights the opportunities of target discovery for drug development. However, detecting the binding relationship between NPs and targets remains challenging. Chemical proteomics, an interdisciplinary field of chemistry, proteomics, biology, and bioinformatics, has emerged as a potential approach for uncovering drug-target interactions. This review summarizes the principles and characteristics of the current widely applied chemical proteomic technologies, while delving into their latest applications in the target discovery of natural medicine. These endeavours demonstrate the potential of chemical proteomics for target discovery to supply dependable methodologies for the target elucidation of NPs. |
| format | Artículo científico |
| id | pubmed_39510194 |
| institution | PubMed |
| language | en |
| publishDate | 2024 |
| publisher | Biochemical pharmacology |
| record_format | pubmed |
| spellingShingle | Chemical proteomics accelerates the target discovery of natural products. He, Shu-Jie Li, Jun Zhou, Jie-Chun Yang, Zhi-You Liu, Xi Ge, Yue-Wei Biological Products Proteomics Humans Drug Discovery Animals Chemical proteomics accelerates the target discovery of natural products. He, Shu-Jie Li, Jun Zhou, Jie-Chun Yang, Zhi-You Liu, Xi Ge, Yue-Wei Biological Products Proteomics Humans Drug Discovery Animals More than half of the global novel drugs are directly or indirectly derived from natural products (NPs) because of their better selectivity towards proteins. Traditional medicines perform multiple bioactivities through various NPs binding to drug targets, which highlights the opportunities of target discovery for drug development. However, detecting the binding relationship between NPs and targets remains challenging. Chemical proteomics, an interdisciplinary field of chemistry, proteomics, biology, and bioinformatics, has emerged as a potential approach for uncovering drug-target interactions. This review summarizes the principles and characteristics of the current widely applied chemical proteomic technologies, while delving into their latest applications in the target discovery of natural medicine. These endeavours demonstrate the potential of chemical proteomics for target discovery to supply dependable methodologies for the target elucidation of NPs. |
| title | Chemical proteomics accelerates the target discovery of natural products. |
| topic | Biological Products Proteomics Humans Drug Discovery Animals |
| url | https://pubmed.ncbi.nlm.nih.gov/39510194/ |