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| Autores principales: | , , |
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| Formato: | Artículo científico |
| Lenguaje: | en |
| Publicado: |
International journal of biological macromolecules
2024
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| Materias: | |
| Acceso en línea: | https://pubmed.ncbi.nlm.nih.gov/39515688/ |
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- Innovative anticancer nanocomposites from Corchorus olitorius mucilage/chitosan/selenium nanoparticles. El-Sherbiny, Mohsen M El-Hefnawy, Mohamed E Tayel, Ahmed A Humans Chitosan Selenium Nanocomposites HeLa Cells Caco-2 Cells Antineoplastic Agents Nanoparticles Plant Mucilage Cell Survival Cancers are continuing to threaten human health globally; the achievement of effectual and biosafe anticancerous compounds is a precious goal. The extraction of Corchorus olitorius mucilage (Jm) and its usage for selenium nanoparticles (SeNPs) biosynthesis was projected. The innovative formulation of bioactive nanocomposites (NCs) from Jm/SeNPs and chitosan nanoparticles (Cht) was also proposed to apply these NCs as effectual anticancers against CaCo-2 and HeLa cancerous cells. The Jm/SeNPs biosynthesis (mean diameter = 6.45 nm) was innovatively achieved and confirmed using infrared and ultraviolet-visible analysis. The constructions of different NCs were done (N1: 2Jm/SeNPs:1Cht; N2: 1Jm/SeNPs:1Cht; and N3: 1Jm/SeNPs:2Cht) with mean particles' diameter of 88.41, 46.86 and 69.35 nm, respectively. The cytotoxicity assay of constructed NCs indicated their potentialities to suppress examined cells; N1 (negatively charged; -16.2 mV) was the most forceful with IC of 12.36 and 73.15 mg/L against CaCo-2 and HeLa cells, respectively. The scanning microscopy imaging of treated CaCo-2 cells with N1 of Cht/Jm/SeNPs indicated that the NCs led to remarkable apoptotic destructions of treated cells, including cell shrinkage, membrane blebbing, cytoplasmic vacuolization, cell debris and apoptotic indices. The innovative NCs from Cht/Jm/SeNPs are promisingly recommended as effectual, natural and bioactive anticancer formulations against human cancers.