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| Natura: | Artículo científico |
| Lingua: | en |
| Pubblicazione: |
International journal of biological macromolecules
2024
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| Soggetti: | |
| Accesso online: | https://pubmed.ncbi.nlm.nih.gov/39522906/ |
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| author | Kim, Tae-Hee Oh, Gun-Woo Heo, Seong-Yeong Heo, Soo-Jin Kim, Young-Mog Lee, Dae-Sung Kang, Hyun Wook Kim, Hyun-Woo Lee, Bongii Choi, Il-Whan Park, Won Sun Jung, Won-Kyo |
| author_facet | Kim, Tae-Hee Oh, Gun-Woo Heo, Seong-Yeong Heo, Soo-Jin Kim, Young-Mog Lee, Dae-Sung Kang, Hyun Wook Kim, Hyun-Woo Lee, Bongii Choi, Il-Whan Park, Won Sun Jung, Won-Kyo Kim, Tae-Hee Oh, Gun-Woo Heo, Seong-Yeong Heo, Soo-Jin Kim, Young-Mog Lee, Dae-Sung Kang, Hyun Wook Kim, Hyun-Woo Lee, Bongii Choi, Il-Whan Park, Won Sun Jung, Won-Kyo |
| collection | PubMed - marine biology |
| contents | 3D-printed polycaprolactone/collagen/alginate scaffold incorporating phlorotannin for bone tissue regeneration: Assessment of sub-chronic toxicity. Kim, Tae-Hee Oh, Gun-Woo Heo, Seong-Yeong Heo, Soo-Jin Kim, Young-Mog Lee, Dae-Sung Kang, Hyun Wook Kim, Hyun-Woo Lee, Bongii Choi, Il-Whan Park, Won Sun Jung, Won-Kyo Animals Tissue Scaffolds Alginates Rabbits Bone Regeneration Printing, Three-Dimensional Polyesters Collagen Tannins Tissue Engineering Bone and Bones The development of effective scaffolds for bone regeneration is crucial given the increasing demand for innovative solutions to address bone defects and enhance healing process. In this study, a polycaprolactone/fish collagen/alginate (P/FC/A) 3D scaffold incorporating phlorotannin was developed to promote bone tissue regeneration. While the efficacy of the P/FC/A scaffold has been demonstrated through in vitro and in vivo experiments, its sub-chronic toxicity in animal models remains understudied, raising concerns regarding its safety in clinical application. Therefore, this study assessed the sub-chronic toxicity of the P/FC/A scaffold over 12 week using a New Zealand White rabbit model. Our results indicate no significant adverse effects in the group exposed to the P/FC/A scaffold compared with the negative control group implanted with a high-density polyethylene scaffold. These findings underscore the non-toxicity and safety profile of the P/FC/A scaffold, further supporting its potential suitability for clinical use in bone regeneration. |
| format | Artículo científico |
| id | pubmed_39522906 |
| institution | PubMed |
| language | en |
| publishDate | 2024 |
| publisher | International journal of biological macromolecules |
| record_format | pubmed |
| spellingShingle | 3D-printed polycaprolactone/collagen/alginate scaffold incorporating phlorotannin for bone tissue regeneration: Assessment of sub-chronic toxicity. Kim, Tae-Hee Oh, Gun-Woo Heo, Seong-Yeong Heo, Soo-Jin Kim, Young-Mog Lee, Dae-Sung Kang, Hyun Wook Kim, Hyun-Woo Lee, Bongii Choi, Il-Whan Park, Won Sun Jung, Won-Kyo Animals Tissue Scaffolds Alginates Rabbits Bone Regeneration Printing, Three-Dimensional Polyesters Collagen Tannins Tissue Engineering Bone and Bones 3D-printed polycaprolactone/collagen/alginate scaffold incorporating phlorotannin for bone tissue regeneration: Assessment of sub-chronic toxicity. Kim, Tae-Hee Oh, Gun-Woo Heo, Seong-Yeong Heo, Soo-Jin Kim, Young-Mog Lee, Dae-Sung Kang, Hyun Wook Kim, Hyun-Woo Lee, Bongii Choi, Il-Whan Park, Won Sun Jung, Won-Kyo Animals Tissue Scaffolds Alginates Rabbits Bone Regeneration Printing, Three-Dimensional Polyesters Collagen Tannins Tissue Engineering Bone and Bones The development of effective scaffolds for bone regeneration is crucial given the increasing demand for innovative solutions to address bone defects and enhance healing process. In this study, a polycaprolactone/fish collagen/alginate (P/FC/A) 3D scaffold incorporating phlorotannin was developed to promote bone tissue regeneration. While the efficacy of the P/FC/A scaffold has been demonstrated through in vitro and in vivo experiments, its sub-chronic toxicity in animal models remains understudied, raising concerns regarding its safety in clinical application. Therefore, this study assessed the sub-chronic toxicity of the P/FC/A scaffold over 12 week using a New Zealand White rabbit model. Our results indicate no significant adverse effects in the group exposed to the P/FC/A scaffold compared with the negative control group implanted with a high-density polyethylene scaffold. These findings underscore the non-toxicity and safety profile of the P/FC/A scaffold, further supporting its potential suitability for clinical use in bone regeneration. |
| title | 3D-printed polycaprolactone/collagen/alginate scaffold incorporating phlorotannin for bone tissue regeneration: Assessment of sub-chronic toxicity. |
| topic | Animals Tissue Scaffolds Alginates Rabbits Bone Regeneration Printing, Three-Dimensional Polyesters Collagen Tannins Tissue Engineering Bone and Bones |
| url | https://pubmed.ncbi.nlm.nih.gov/39522906/ |