Discovery of the First-in-Class Dual-Target ROCK/HDAC Inhibitor with Potent Antitumor Efficacy in Vivo That Trigger Antitumor Immunity.
Fuente:
PubMed
Guardado en:
| Autores principales: | Mao, Churu, Fang, Jiebin, Zou, Shijie, Huang, Yun, Chen, Xiaoming, Ding, Xia, Fang, Zhangyun, Zhang, Ningjing, Lou, Yijie, Chen, Zhe, Ding, Wanjing, Ma, Zhongjun |
|---|---|
| Formato: | Artículo científico |
| Lenguaje: | en |
| Publicado: |
Journal of medicinal chemistry
2024
|
| Materias: | |
| Acceso en línea: | |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
Ejemplares similares
Design, synthesis, and biological evaluation of N-(2-amino-phenyl)-5-(4-aryl- pyrimidin-2-yl) amino)-1H-indole-2-carboxamide derivatives as novel inhibitors of CDK9 and class I HDACs for cancer treatment.
por: Chen, Xiaohui, et al.
Publicado: (2025)
por: Chen, Xiaohui, et al.
Publicado: (2025)
Design, Synthesis, and Evaluation of a Potent and Selective ROCK2 Inhibitor for Atopic Dermatitis Treatment.
por: Mao, Churu, et al.
Publicado: (2026)
por: Mao, Churu, et al.
Publicado: (2026)
Chemical Evolution of Aplithianine Class of Serine/Threonine Kinase Inhibitors.
por: Du, Lin, et al.
Publicado: (2025)
por: Du, Lin, et al.
Publicado: (2025)
Supplementary data for "The histone code of love: epigenetics of maturation of gonads in the human blood fluke Schistosoma mansoni"
por: Grunau, Christoph
Publicado: (2026)
por: Grunau, Christoph
Publicado: (2026)
Discovery of 4-(2-(methylamino)thiazol-5-yl)pyrimidin-2-amine derivatives as novel cyclin-dependent kinase 12 (CDK12) inhibitors for the treatment of esophageal squamous cell carcinoma.
por: Cao, Yin, et al.
Publicado: (2025)
por: Cao, Yin, et al.
Publicado: (2025)
Impact of histone post-translational modification inhibitors on lifespan, reproduction, and stress response in the rotifer Brachionus manjavacas.
por: Luviano Aparicio, Nelia, et al.
Publicado: (2025)
por: Luviano Aparicio, Nelia, et al.
Publicado: (2025)
Degradation of NLRP3 by selective ROCK2 inhibitor alleviates acute lung injury.
por: Zhan, Shuai, et al.
Publicado: (2025)
por: Zhan, Shuai, et al.
Publicado: (2025)
Discovery of an orally bioavailable pyridone-based BRD4 inhibitor with potent antitumor efficacy in colorectal cancer.
por: Fang, Zhangyun, et al.
Publicado: (2026)
por: Fang, Zhangyun, et al.
Publicado: (2026)
Prediction of newly synthesized heparin mimic's effects as heparanase inhibitor in cancer treatments via variational quantum neural networks.
por: Kocabay, Samet, et al.
Publicado: (2025)
por: Kocabay, Samet, et al.
Publicado: (2025)
Discovery of novel thiosemicarbazone dimers as effective inhibitors of poly(ADP-ribose) polymerase-1 (PARP-1) for use in cancer therapy.
por: Wang, Lijun, et al.
Publicado: (2026)
por: Wang, Lijun, et al.
Publicado: (2026)
Activation of the γ-secretase/NICD-PXR/Notch pathway induces Taxol resistance in triple-negative breast cancer.
por: Wang, Zuo-Jun, et al.
Publicado: (2024)
por: Wang, Zuo-Jun, et al.
Publicado: (2024)
Synthesis and biological activity of 1H-pyrrolo[3,2-g]isoquinolines as Haspin kinase inhibitors.
por: Malosse, Killian, et al.
Publicado: (2025)
por: Malosse, Killian, et al.
Publicado: (2025)
New Fusarochromanone Derivatives from the Marine Fungus UBOCC-A-117302.
por: Pham, Giang Nam, et al.
Publicado: (2024)
por: Pham, Giang Nam, et al.
Publicado: (2024)
Identification of EEF1A1 as a therapeutic target in TNBC: Anticancer action of a novel Penicillide-derived inhibitor through ribosomal protein regulation.
por: Yu, Jing, et al.
Publicado: (2026)
por: Yu, Jing, et al.
Publicado: (2026)
Integrating experimental findings and machine learning models to predict the anticancer potential of newly synthesized oversulfated fucoidan.
por: Kocabay, Samet, et al.
Publicado: (2026)
por: Kocabay, Samet, et al.
Publicado: (2026)
Inhibition of Na,K -ATPase enzyme by tetrodotoxin extract in the breast tumor xenograft Balb/c nu mouse model.
por: Ahrari, Ameneh, et al.
Publicado: (2025)
por: Ahrari, Ameneh, et al.
Publicado: (2025)
Marine Natural Product Chagosendine C Induces Cuproptosis in Colorectal Cancer Cells by Targeting FDX1.
por: Tao, Xiaoyu, et al.
Publicado: (2025)
por: Tao, Xiaoyu, et al.
Publicado: (2025)
Identification of novel CLK1 inhibitors by computational fragment-based ligand design, co-crystallization, chemical synthesis and structure activity relationships.
por: Bourg, Stéphane, et al.
Publicado: (2026)
por: Bourg, Stéphane, et al.
Publicado: (2026)
MEK1/2 inhibition prevents DENV and ZIKV infection via disrupting the cytoskeletal vimentin cage required for viral replication.
por: Huang, Yuhan, et al.
Publicado: (2026)
por: Huang, Yuhan, et al.
Publicado: (2026)
DGMM: A Deep Learning-Genetic Algorithm Framework for Efficient Lead Optimization in Drug Discovery.
por: Fang, Jiebin, et al.
Publicado: (2025)
por: Fang, Jiebin, et al.
Publicado: (2025)
Total syntheses of Kavaratamide A and 5--Kavaratamide A.
por: Ren, Tieshun, et al.
Publicado: (2025)
por: Ren, Tieshun, et al.
Publicado: (2025)
Investigating the C2 Modulation of the Imidazo[1,2-a]pyrazine-Based Hit Compound CTN1122: Synthesis, in vitro Antileishmanial Activity, Cytotoxicity and Casein Kinase 1 Inhibition.
por: Tisseur, Lhana, et al.
Publicado: (2025)
por: Tisseur, Lhana, et al.
Publicado: (2025)
Target Screening and Validation of the Antitumor Effect of Saponin Extract From Holothuria leucospilota.
por: Xu, Fuju, et al.
Publicado: (2025)
por: Xu, Fuju, et al.
Publicado: (2025)
Design and Synthesis of Marine Sarocladione Derivatives with Potential Anticancer Activity.
por: Liu, Xiao-Mei, et al.
Publicado: (2026)
por: Liu, Xiao-Mei, et al.
Publicado: (2026)
Metabolic Blockade-Based Genome Mining of SCSIO 07745: Discovery and Biosynthetic Pathway of Aminoquinolinone Alkaloids Bearing 6/6/5 Tricyclic and 6/6/6/5 Tetracyclic Scaffolds.
por: Li, Kunlong, et al.
Publicado: (2025)
por: Li, Kunlong, et al.
Publicado: (2025)
Histone Deacetylase 6 Regulates α-Tubulin to Inhibit the Stimulator of Interferon Genes/NLR Family Pyrin Domain-Containing 3-Mediated Microglial Pyroptosis Induced by Herpes Simplex Virus Type 1 Infection.
por: Zeng, Qiongzhen, et al.
Publicado: (2026)
por: Zeng, Qiongzhen, et al.
Publicado: (2026)
Sun Exposure and Skin Cancer: A Narrative Review of Risk Factors, Prevention Behaviors, and Emerging Therapeutic Approaches
por: Silva, Luiz Felipe Rodrigues, et al.
Publicado: (2026)
por: Silva, Luiz Felipe Rodrigues, et al.
Publicado: (2026)
Sclerohumins G-L: Selective cytotoxic diterpenoids featuring a 4/9-fused ring system from the soft coral Sclerophytum humesi.
por: Luu, Phuong Vu, et al.
Publicado: (2026)
por: Luu, Phuong Vu, et al.
Publicado: (2026)
Pyrimidine Nucleosides, Benzoic Acid Derivative, and Bipyridine From the Marine-Derived Streptomyces Sp. DS52.
por: Xia, Meng-de, et al.
Publicado: (2025)
por: Xia, Meng-de, et al.
Publicado: (2025)
Ultrasonication-assisted green synthesis, in silico EGFR-binding analysis, and cytotoxic evaluation of nitro-perimidines for non-small cell lung cancer.
por: Gopinadh, Meera, et al.
Publicado: (2026)
por: Gopinadh, Meera, et al.
Publicado: (2026)
Tumor Microenvironment-Responsive Multinucleated Nanocomplexes Loaded with Carbon Dots for Combined Photothermal/Chemodynamic Therapy of Breast Cancer.
por: Zhu, Zihan, et al.
Publicado: (2025)
por: Zhu, Zihan, et al.
Publicado: (2025)
Preparation of mitochondria-targeted camptothecin derivatives for the imaging and antiproliferation of colorectal cancer.
por: Xu, Chenmeng, et al.
Publicado: (2025)
por: Xu, Chenmeng, et al.
Publicado: (2025)
NSD2 targeting reverses plasticity and drug resistance in prostate cancer.
por: Li, Jia J, et al.
Publicado: (2026)
por: Li, Jia J, et al.
Publicado: (2026)
Synthesis of mitochondria-targeted podophyllotoxin derivatives for the imaging and antiproliferation of liver cancer.
por: Xu, Chenmeng, et al.
Publicado: (2026)
por: Xu, Chenmeng, et al.
Publicado: (2026)
Ircindrimanes A-I, nine undescribed meroterpenoids with cytotoxic activities from the marine sponge Ircinia sp.
por: Zhang, Wenjie, et al.
Publicado: (2025)
por: Zhang, Wenjie, et al.
Publicado: (2025)
Shimojilide, a Potent and Selective Antiproliferative Cyclic Lipopeptide from a Marine Cyanobacterium sp.
por: Niiyama, Mizuho, et al.
Publicado: (2026)
por: Niiyama, Mizuho, et al.
Publicado: (2026)
Rewiring mTOR signaling in Alzheimer's disease: emerging mTOR modulators beyond oncology.
por: Lohnes, Benedikt Jakob, et al.
Publicado: (2026)
por: Lohnes, Benedikt Jakob, et al.
Publicado: (2026)
Anticancer Effects of Monacolin X Against Human Liver Cancer Cell Line: Exploring the Apoptosis Using AO/EB and DCFHDA Fluorescent Staining.
por: Jayaraman, Vennila, et al.
Publicado: (2025)
por: Jayaraman, Vennila, et al.
Publicado: (2025)
Total Synthesis of Nocarterphenyl A, 2-Dehydroxymethylnocarterphenyl A and Nocarterphenyl D Produced by Marine spp.
por: Xu, Quan, et al.
Publicado: (2025)
por: Xu, Quan, et al.
Publicado: (2025)
PPTase-Based Activation Unlocks New Anthraquinones from Marine-Derived sp. SCSIO 07396.
por: Li, Xiaohua, et al.
Publicado: (2026)
por: Li, Xiaohua, et al.
Publicado: (2026)
Ejemplares similares
-
Design, synthesis, and biological evaluation of N-(2-amino-phenyl)-5-(4-aryl- pyrimidin-2-yl) amino)-1H-indole-2-carboxamide derivatives as novel inhibitors of CDK9 and class I HDACs for cancer treatment.
por: Chen, Xiaohui, et al.
Publicado: (2025) -
Design, Synthesis, and Evaluation of a Potent and Selective ROCK2 Inhibitor for Atopic Dermatitis Treatment.
por: Mao, Churu, et al.
Publicado: (2026) -
Chemical Evolution of Aplithianine Class of Serine/Threonine Kinase Inhibitors.
por: Du, Lin, et al.
Publicado: (2025) -
Supplementary data for "The histone code of love: epigenetics of maturation of gonads in the human blood fluke Schistosoma mansoni"
por: Grunau, Christoph
Publicado: (2026) -
Discovery of 4-(2-(methylamino)thiazol-5-yl)pyrimidin-2-amine derivatives as novel cyclin-dependent kinase 12 (CDK12) inhibitors for the treatment of esophageal squamous cell carcinoma.
por: Cao, Yin, et al.
Publicado: (2025)