Staff View: :: Library Catalog

Saved in:

Bibliographic Details
Main Authors:	Prasongpholchai, Panward, Tucker, Sam, Burgess, Charles, Jenkins, Robert, Wilkening, Ina, Corre, Christophe, Song, Lijiang, Tosin, Manuela
Format:	Artículo científico
Language:	en
Published:	Chemical communications (Cambridge, England) 2024
Subjects:	Rhodococcus Polyketide Synthases Polyenes
Online Access:	https://pubmed.ncbi.nlm.nih.gov/39526441/
Tags:	Add Tag No Tags, Be the first to tag this record!

_version_	1868266282452779008
author	Prasongpholchai, Panward Tucker, Sam Burgess, Charles Jenkins, Robert Wilkening, Ina Corre, Christophe Song, Lijiang Tosin, Manuela
author_facet	Prasongpholchai, Panward Tucker, Sam Burgess, Charles Jenkins, Robert Wilkening, Ina Corre, Christophe Song, Lijiang Tosin, Manuela Prasongpholchai, Panward Tucker, Sam Burgess, Charles Jenkins, Robert Wilkening, Ina Corre, Christophe Song, Lijiang Tosin, Manuela
collection	PubMed - marine biology
contents	Extended polyene formation by a cryptic iterative polyketide synthase from . Prasongpholchai, Panward Tucker, Sam Burgess, Charles Jenkins, Robert Wilkening, Ina Corre, Christophe Song, Lijiang Tosin, Manuela Rhodococcus Polyketide Synthases Polyenes Many reactive intermediates leading to high value molecules are biosynthesised by multifunctional enzymes in Actinobacteria. Herein we report the workings of a cryptic iterative polyketide synthase (iPKS) from the marine microorganism PR4. The iPKS generates extended polyenes up to C22 nonaenes, preluding novel chemistry and biology.
format	Artículo científico
id	pubmed_39526441
institution	PubMed
language	en
publishDate	2024
publisher	Chemical communications (Cambridge, England)
record_format	pubmed
spellingShingle	Extended polyene formation by a cryptic iterative polyketide synthase from . Prasongpholchai, Panward Tucker, Sam Burgess, Charles Jenkins, Robert Wilkening, Ina Corre, Christophe Song, Lijiang Tosin, Manuela Rhodococcus Polyketide Synthases Polyenes Extended polyene formation by a cryptic iterative polyketide synthase from . Prasongpholchai, Panward Tucker, Sam Burgess, Charles Jenkins, Robert Wilkening, Ina Corre, Christophe Song, Lijiang Tosin, Manuela Rhodococcus Polyketide Synthases Polyenes Many reactive intermediates leading to high value molecules are biosynthesised by multifunctional enzymes in Actinobacteria. Herein we report the workings of a cryptic iterative polyketide synthase (iPKS) from the marine microorganism PR4. The iPKS generates extended polyenes up to C22 nonaenes, preluding novel chemistry and biology.
title	Extended polyene formation by a cryptic iterative polyketide synthase from .
topic	Rhodococcus Polyketide Synthases Polyenes
url	https://pubmed.ncbi.nlm.nih.gov/39526441/

if (filemtime($filename) + $maxlifetime < time()) { unlink($filename); $count++; } } return $count; } /** * A function that is called internally when session data is to be saved. * * @param string $sessId The current session ID * @param string $data The session data to write * * @return bool */ protected function saveSession($sessId, $data): bool { $sessFile = $this->path . '/sess_' . $sessId; if ($handle = fopen($sessFile, 'w')) { $return = false; // Lock the file for exclusive access to avoid issues with multiple // processes writing session simultaneously: if (flock($handle, LOCK_EX)) { $return = fwrite($handle, $data); // Make sure that there's no trailing data by truncating the file to // the correct length: ftruncate($handle, strlen($data)); fflush($handle); flock($handle, LOCK_UN); } fclose($handle); if ($return !== false) { return true; } } // If we got this far, something went wrong with the file output... // It is tempting to throw an exception here, but this code is called // outside of the context of exception handling, so all we can do is // echo a message.

// Anecdotal testing Today and Yesterday seems to indicate destroy() // is called by the garbage collector and everything is good. // Something to keep in mind though. return 0; } /** * Write function that is called when session data is to be saved. * * @param string $sessId The current session ID * @param string $data The session data to write * * @return bool */ public function write($sessId, $data): bool { if ($this->writesDisabled) { return true; } return $this->saveSession($sessId, $data); } /** * A function that is called internally when session data is to be saved. * * @param string $sessId The current session ID * @param string $data The session data to write * * @return bool */ abstract protected function saveSession($sessId, $data): bool; }

* * @return void */ public function writeClose() { // The assumption is that we're using PHP's ext/session. // session_write_close() will actually overwrite $_SESSION with an // empty array on completion -- which leads to a mismatch between what // is in the storage object and $_SESSION. To get around this, we // temporarily reset $_SESSION to an array, and then re-link it to // the storage object. // // Additionally, while you _can_ write to $_SESSION following a // session_write_close() operation, no changes made to it will be // flushed to the session handler. As such, we now mark the storage // object isImmutable. $storage = $this->getStorage(); if (! $storage->isImmutable()) { $_SESSION = $storage->toArray(true); session_write_close(); $storage->fromArray($_SESSION); $storage->markImmutable(); } } /** * Attempt to set the session name * * If the session has already been started, or if the name provided fails * validation, an exception will be raised. * * @param string $name * @return SessionManager * @throws Exception\InvalidArgumentException */ public function setName($name) { if ($this->sessionExists()) { throw new Exception\InvalidArgumentException( 'Cannot set session name after a session has already started'

Environment & details:

GET Data empty

POST Data empty

Files empty

Key	Value
language	"en"
VUFIND_SESSION	"60b876e462339b739f0d8ebcd96f1a43"
ui	"standard"

Session

Key	Value
__Laminas	array:2 [`"_REQUEST_ACCESS_TIME" => 1784573437.6749 "_VALID" => array:1 [ "Laminas\Session\Validator\Id" => "60b876e462339b739f0d8ebcd96f1a43" ]`]
SessionState	Laminas\Stdlib\ArrayObject {#938}
FlashMessenger	Laminas\Stdlib\ArrayObject {#1578}
SessionHelper	Laminas\Stdlib\ArrayObject {#1776}

Server/Request Data

Key	Value
REDIRECT_VUFIND_LOCAL_DIR	"/usr/local/vufind/local"
REDIRECT_HTTPS	"on"
REDIRECT_SSL_TLS_SNI	"info.umar.mx"
REDIRECT_STATUS	"200"
VUFIND_LOCAL_DIR	"/usr/local/vufind/local"
HTTPS	"on"
SSL_TLS_SNI	"info.umar.mx"
HTTP_ACCEPT	"/"
HTTP_USER_AGENT	"Mozilla/5.0 AppleWebKit/537.36 (KHTML, like Gecko; compatible; ClaudeBot/1.0; +claudebot@anthropic.com)"
HTTP_COOKIE	"language=en; VUFIND_SESSION=60b876e462339b739f0d8ebcd96f1a43; ui=standard"
HTTP_ACCEPT_ENCODING	"gzip, br, zstd, deflate"
HTTP_HOST	"info.umar.mx"
PATH	"/usr/local/sbin:/usr/local/bin:/usr/sbin:/usr/bin:/snap/bin"
SERVER_SIGNATURE	"<address>Apache/2.4.66 (Ubuntu) Server at info.umar.mx Port 443</address>\n"
SERVER_SOFTWARE	"Apache/2.4.66 (Ubuntu)"
SERVER_NAME	"info.umar.mx"
SERVER_ADDR	"200.23.222.19"
SERVER_PORT	"443"
REMOTE_ADDR	"216.73.216.85"
DOCUMENT_ROOT	"/usr/local/vufind/public"
REQUEST_SCHEME	"https"
CONTEXT_PREFIX	""
CONTEXT_DOCUMENT_ROOT	"/usr/local/vufind/public"
SERVER_ADMIN	"admin@localhost"
SCRIPT_FILENAME	"/usr/local/vufind/public/index.php"
REMOTE_PORT	"48833"
REDIRECT_URL	"/Record/pubmed_39526441/Details"
GATEWAY_INTERFACE	"CGI/1.1"
SERVER_PROTOCOL	"HTTP/1.1"
REQUEST_METHOD	"GET"
QUERY_STRING	""
REQUEST_URI	"/Record/pubmed_39526441/Details"
SCRIPT_NAME	"/index.php"
PHP_SELF	"/index.php"
REQUEST_TIME_FLOAT	1784573437.6559
REQUEST_TIME	1784573437

Environment Variables empty

Registered Handlers

0. Whoops\Handler\PrettyPageHandler

Environment & details:

GET Data empty

POST Data empty

Files empty

Key	Value
language	"en"
VUFIND_SESSION	"60b876e462339b739f0d8ebcd96f1a43"
ui	"standard"

Session

Key	Value
__Laminas	array:2 [`"_REQUEST_ACCESS_TIME" => 1784573437.6749 "_VALID" => array:1 [ "Laminas\Session\Validator\Id" => "60b876e462339b739f0d8ebcd96f1a43" ]`]
SessionState	Laminas\Stdlib\ArrayObject {#938}
FlashMessenger	Laminas\Stdlib\ArrayObject {#1578}
SessionHelper	Laminas\Stdlib\ArrayObject {#1776}

Server/Request Data

Key	Value
REDIRECT_VUFIND_LOCAL_DIR	"/usr/local/vufind/local"
REDIRECT_HTTPS	"on"
REDIRECT_SSL_TLS_SNI	"info.umar.mx"
REDIRECT_STATUS	"200"
VUFIND_LOCAL_DIR	"/usr/local/vufind/local"
HTTPS	"on"
SSL_TLS_SNI	"info.umar.mx"
HTTP_ACCEPT	"/"
HTTP_USER_AGENT	"Mozilla/5.0 AppleWebKit/537.36 (KHTML, like Gecko; compatible; ClaudeBot/1.0; +claudebot@anthropic.com)"
HTTP_COOKIE	"language=en; VUFIND_SESSION=60b876e462339b739f0d8ebcd96f1a43; ui=standard"
HTTP_ACCEPT_ENCODING	"gzip, br, zstd, deflate"
HTTP_HOST	"info.umar.mx"
PATH	"/usr/local/sbin:/usr/local/bin:/usr/sbin:/usr/bin:/snap/bin"
SERVER_SIGNATURE	"<address>Apache/2.4.66 (Ubuntu) Server at info.umar.mx Port 443</address>\n"
SERVER_SOFTWARE	"Apache/2.4.66 (Ubuntu)"
SERVER_NAME	"info.umar.mx"
SERVER_ADDR	"200.23.222.19"
SERVER_PORT	"443"
REMOTE_ADDR	"216.73.216.85"
DOCUMENT_ROOT	"/usr/local/vufind/public"
REQUEST_SCHEME	"https"
CONTEXT_PREFIX	""
CONTEXT_DOCUMENT_ROOT	"/usr/local/vufind/public"
SERVER_ADMIN	"admin@localhost"
SCRIPT_FILENAME	"/usr/local/vufind/public/index.php"
REMOTE_PORT	"48833"
REDIRECT_URL	"/Record/pubmed_39526441/Details"
GATEWAY_INTERFACE	"CGI/1.1"
SERVER_PROTOCOL	"HTTP/1.1"
REQUEST_METHOD	"GET"
QUERY_STRING	""
REQUEST_URI	"/Record/pubmed_39526441/Details"
SCRIPT_NAME	"/index.php"
PHP_SELF	"/index.php"
REQUEST_TIME_FLOAT	1784573437.6559
REQUEST_TIME	1784573437

Environment Variables empty

Registered Handlers

0. Whoops\Handler\PrettyPageHandler

Similar Items

Environment & details:

Environment & details: