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| Natura: | Artículo científico |
| Lingua: | en |
| Pubblicazione: |
Nature communications
2024
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| Soggetti: | |
| Accesso online: | https://pubmed.ncbi.nlm.nih.gov/39528516/ |
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| _version_ | 1868266282450681857 |
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| author | Chen, Zhengfang He, Mudan Wang, Houpeng Li, Xuehui Qin, Ruirui Ye, Ding Zhai, Xue Zhu, Junwen Zhang, Quanqing Hu, Peng Shui, Guanghou Sun, Yonghua |
| author_facet | Chen, Zhengfang He, Mudan Wang, Houpeng Li, Xuehui Qin, Ruirui Ye, Ding Zhai, Xue Zhu, Junwen Zhang, Quanqing Hu, Peng Shui, Guanghou Sun, Yonghua Chen, Zhengfang He, Mudan Wang, Houpeng Li, Xuehui Qin, Ruirui Ye, Ding Zhai, Xue Zhu, Junwen Zhang, Quanqing Hu, Peng Shui, Guanghou Sun, Yonghua |
| collection | PubMed - marine biology |
| contents | Intestinal DHA-PA-PG axis promotes digestive organ expansion by mediating usage of maternally deposited yolk lipids. Chen, Zhengfang He, Mudan Wang, Houpeng Li, Xuehui Qin, Ruirui Ye, Ding Zhai, Xue Zhu, Junwen Zhang, Quanqing Hu, Peng Shui, Guanghou Sun, Yonghua Animals Zebrafish Docosahexaenoic Acids Zebrafish Proteins Intestines Egg Yolk Embryonic Development Intestinal Mucosa Gene Expression Regulation, Developmental Embryo, Nonmammalian Larva Lipid Metabolism Pancreas, Exocrine Although the metabolism of yolk lipids such as docosahexaenoic acid (DHA) is pivotal for embryonic development, the underlying mechanism remains elusive. Here we find that the zebrafish hydroxysteroid (17-β) dehydrogenase 12a (hsd17b12a), which encodes an intestinal epithelial-specific enzyme, is essential for the biosynthesis of long-chain polyunsaturated fatty acids in primitive intestine of larval fish. The deficiency of hsd17b12a leads to severe developmental defects in the primitive intestine and exocrine pancreas. Mechanistically, hsd17b12a deficiency interrupts DHA synthesis from essential fatty acids derived from yolk-deposited triglycerides, and consequently disrupts the intestinal DHA-phosphatidic acid (PA)-phosphatidylglycerol (PG) axis. This ultimately results in developmental defects of digestive organs, primarily driven by ferroptosis. Our findings indicate that the DHA-PA-PG axis in the primitive intestine facilitates the uptake of yolk lipids and promotes the expansion of digestive organs, thereby uncovering a mechanism through which DHA regulates embryonic development. |
| format | Artículo científico |
| id | pubmed_39528516 |
| institution | PubMed |
| language | en |
| publishDate | 2024 |
| publisher | Nature communications |
| record_format | pubmed |
| spellingShingle | Intestinal DHA-PA-PG axis promotes digestive organ expansion by mediating usage of maternally deposited yolk lipids. Chen, Zhengfang He, Mudan Wang, Houpeng Li, Xuehui Qin, Ruirui Ye, Ding Zhai, Xue Zhu, Junwen Zhang, Quanqing Hu, Peng Shui, Guanghou Sun, Yonghua Animals Zebrafish Docosahexaenoic Acids Zebrafish Proteins Intestines Egg Yolk Embryonic Development Intestinal Mucosa Gene Expression Regulation, Developmental Embryo, Nonmammalian Larva Lipid Metabolism Pancreas, Exocrine Intestinal DHA-PA-PG axis promotes digestive organ expansion by mediating usage of maternally deposited yolk lipids. Chen, Zhengfang He, Mudan Wang, Houpeng Li, Xuehui Qin, Ruirui Ye, Ding Zhai, Xue Zhu, Junwen Zhang, Quanqing Hu, Peng Shui, Guanghou Sun, Yonghua Animals Zebrafish Docosahexaenoic Acids Zebrafish Proteins Intestines Egg Yolk Embryonic Development Intestinal Mucosa Gene Expression Regulation, Developmental Embryo, Nonmammalian Larva Lipid Metabolism Pancreas, Exocrine Although the metabolism of yolk lipids such as docosahexaenoic acid (DHA) is pivotal for embryonic development, the underlying mechanism remains elusive. Here we find that the zebrafish hydroxysteroid (17-β) dehydrogenase 12a (hsd17b12a), which encodes an intestinal epithelial-specific enzyme, is essential for the biosynthesis of long-chain polyunsaturated fatty acids in primitive intestine of larval fish. The deficiency of hsd17b12a leads to severe developmental defects in the primitive intestine and exocrine pancreas. Mechanistically, hsd17b12a deficiency interrupts DHA synthesis from essential fatty acids derived from yolk-deposited triglycerides, and consequently disrupts the intestinal DHA-phosphatidic acid (PA)-phosphatidylglycerol (PG) axis. This ultimately results in developmental defects of digestive organs, primarily driven by ferroptosis. Our findings indicate that the DHA-PA-PG axis in the primitive intestine facilitates the uptake of yolk lipids and promotes the expansion of digestive organs, thereby uncovering a mechanism through which DHA regulates embryonic development. |
| title | Intestinal DHA-PA-PG axis promotes digestive organ expansion by mediating usage of maternally deposited yolk lipids. |
| topic | Animals Zebrafish Docosahexaenoic Acids Zebrafish Proteins Intestines Egg Yolk Embryonic Development Intestinal Mucosa Gene Expression Regulation, Developmental Embryo, Nonmammalian Larva Lipid Metabolism Pancreas, Exocrine |
| url | https://pubmed.ncbi.nlm.nih.gov/39528516/ |