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| Autores principales: | , , , , , , , , , , , , |
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| Formato: | Artículo científico |
| Lenguaje: | en |
| Publicado: |
Scientific data
2024
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| Materias: | |
| Acceso en línea: | https://pubmed.ncbi.nlm.nih.gov/39572589/ |
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- Expanding the genome information on Bacillales for biosynthetic gene cluster discovery. Song, Lijie Nielsen, Lasse Johan Dyrbye Xu, Xinming Mohite, Omkar Satyavan Nuhamunada, Matin Xu, Zhihui Murphy, Rob Bodawatta, Kasun Poulsen, Michael Abdulla, Mohamed Hatha Sonnenschein, Eva C Weber, Tilmann Kovács, Ákos T Multigene Family Genome, Bacterial Bacillus Phylogeny Secondary Metabolism This study showcases 121 new genomes of spore-forming Bacillales from strains collected globally from a variety of habitats, assembled using Oxford Nanopore long-read and MGI short-read sequences. Bacilli are renowned for their capacity to produce diverse secondary metabolites with use in agriculture, biotechnology, and medicine. These secondary metabolites are encoded within biosynthetic gene clusters (smBGCs). smBGCs have significant research interest due to their potential as sources of new bioactivate compounds. Our dataset includes 62 complete genomes, 2 at chromosome level, and 57 at contig level, covering a genomic size range from 3.50 Mb to 7.15 Mb. Phylotaxonomic analysis revealed that these genomes span 16 genera, with 69 of them belonging to Bacillus. A total of 1,176 predicted BGCs were identified by in silico genome mining. We anticipate that the open-access data presented here will expand the reported genomic information of spore-forming Bacillales and facilitate a deeper understanding of the genetic basis of Bacillales' potential for secondary metabolite production.