New Polyhydroxysteroid Glycosides with Antioxidant Activity from the Far Eastern Sea Star .
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| Autori principali: | , , , , , , , , |
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| Natura: | Artículo científico |
| Lingua: | en |
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Marine drugs
2024
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| author | Malyarenko, Timofey V Zakharenko, Viktor M Kicha, Alla A Ponomarenko, Arina I Manzhulo, Igor V Kalinovsky, Anatoly I Popov, Roman S Dmitrenok, Pavel S Ivanchina, Natalia V |
| author_facet | Malyarenko, Timofey V Zakharenko, Viktor M Kicha, Alla A Ponomarenko, Arina I Manzhulo, Igor V Kalinovsky, Anatoly I Popov, Roman S Dmitrenok, Pavel S Ivanchina, Natalia V Malyarenko, Timofey V Zakharenko, Viktor M Kicha, Alla A Ponomarenko, Arina I Manzhulo, Igor V Kalinovsky, Anatoly I Popov, Roman S Dmitrenok, Pavel S Ivanchina, Natalia V |
| collection | PubMed - marine biology |
| contents | New Polyhydroxysteroid Glycosides with Antioxidant Activity from the Far Eastern Sea Star . Malyarenko, Timofey V Zakharenko, Viktor M Kicha, Alla A Ponomarenko, Arina I Manzhulo, Igor V Kalinovsky, Anatoly I Popov, Roman S Dmitrenok, Pavel S Ivanchina, Natalia V Animals Starfish Glycosides Antioxidants Mice Lipopolysaccharides Cell Line Microglia Steroids Inflammation Four new glycosides of polyhydroxysteroids, ceramasterosides A, B, D, and E (-), and two previously known compounds, ceramasteroside C () and attenuatoside B-I (), were isolated from an extract of a deep-sea sea star species, the orange cookie star . The structures of - were elucidated by the extensive NMR and ESIMS methods. Steroid monoglycosides and had a common 3β,6α,8,15β,16β-pentahydroxysteroid nucleus and a C-29 oxidized stigmastane side chain and differed from each other only in monosaccharide residues. Ceramasteroside A () contained 3--methyl-4--sulfated β-D-xylopyranose, while ceramasteroside B () had 3--methyl-4--sulfated β-D-glucopyranose, recorded from starfish-derived steroid glycosides for the first time. Their biological activity was studied using a model of lipopolysaccharide-induced (LPS) inflammation in a SIM-A9 murine microglial cell line. During the LPS-induced activation of microglial cells, , , and , at a non-toxic concentration of 1 µM, showed the highest efficiency in reducing the production of intracellular NO, while proved to be most efficient in reducing the extracellular nitrite production. All the test compounds reduced the LPS-induced malondialdehyde (MDA) production. The in vitro experiments have demonstrated, for the first time, the antioxidant activity of the compounds under study. |
| format | Artículo científico |
| id | pubmed_39590788 |
| institution | PubMed |
| language | en |
| publishDate | 2024 |
| publisher | Marine drugs |
| record_format | pubmed |
| spellingShingle | New Polyhydroxysteroid Glycosides with Antioxidant Activity from the Far Eastern Sea Star . Malyarenko, Timofey V Zakharenko, Viktor M Kicha, Alla A Ponomarenko, Arina I Manzhulo, Igor V Kalinovsky, Anatoly I Popov, Roman S Dmitrenok, Pavel S Ivanchina, Natalia V Animals Starfish Glycosides Antioxidants Mice Lipopolysaccharides Cell Line Microglia Steroids Inflammation New Polyhydroxysteroid Glycosides with Antioxidant Activity from the Far Eastern Sea Star . Malyarenko, Timofey V Zakharenko, Viktor M Kicha, Alla A Ponomarenko, Arina I Manzhulo, Igor V Kalinovsky, Anatoly I Popov, Roman S Dmitrenok, Pavel S Ivanchina, Natalia V Animals Starfish Glycosides Antioxidants Mice Lipopolysaccharides Cell Line Microglia Steroids Inflammation Four new glycosides of polyhydroxysteroids, ceramasterosides A, B, D, and E (-), and two previously known compounds, ceramasteroside C () and attenuatoside B-I (), were isolated from an extract of a deep-sea sea star species, the orange cookie star . The structures of - were elucidated by the extensive NMR and ESIMS methods. Steroid monoglycosides and had a common 3β,6α,8,15β,16β-pentahydroxysteroid nucleus and a C-29 oxidized stigmastane side chain and differed from each other only in monosaccharide residues. Ceramasteroside A () contained 3--methyl-4--sulfated β-D-xylopyranose, while ceramasteroside B () had 3--methyl-4--sulfated β-D-glucopyranose, recorded from starfish-derived steroid glycosides for the first time. Their biological activity was studied using a model of lipopolysaccharide-induced (LPS) inflammation in a SIM-A9 murine microglial cell line. During the LPS-induced activation of microglial cells, , , and , at a non-toxic concentration of 1 µM, showed the highest efficiency in reducing the production of intracellular NO, while proved to be most efficient in reducing the extracellular nitrite production. All the test compounds reduced the LPS-induced malondialdehyde (MDA) production. The in vitro experiments have demonstrated, for the first time, the antioxidant activity of the compounds under study. |
| title | New Polyhydroxysteroid Glycosides with Antioxidant Activity from the Far Eastern Sea Star . |
| topic | Animals Starfish Glycosides Antioxidants Mice Lipopolysaccharides Cell Line Microglia Steroids Inflammation |
| url | https://pubmed.ncbi.nlm.nih.gov/39590788/ |