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| Main Authors: | , , , , |
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| Format: | Artículo científico |
| Language: | en |
| Published: |
Chemistry & biodiversity
2025
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| Online Access: | https://pubmed.ncbi.nlm.nih.gov/39601488/ |
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| _version_ | 1868266275370696706 |
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| author | Xia, Meng-de Fang, Jie-Bin Huang, Yun Chen, Shuang Ma, Zhong-Jun |
| author_facet | Xia, Meng-de Fang, Jie-Bin Huang, Yun Chen, Shuang Ma, Zhong-Jun Xia, Meng-de Fang, Jie-Bin Huang, Yun Chen, Shuang Ma, Zhong-Jun |
| collection | PubMed - marine biology |
| contents | Pyrimidine Nucleosides, Benzoic Acid Derivative, and Bipyridine From the Marine-Derived Streptomyces Sp. DS52. Xia, Meng-de Fang, Jie-Bin Huang, Yun Chen, Shuang Ma, Zhong-Jun Humans Streptomyces Drug Screening Assays, Antitumor Antineoplastic Agents Cell Line, Tumor Pyrimidine Nucleosides Molecular Structure Structure-Activity Relationship Cell Proliferation Benzoic Acid Dose-Response Relationship, Drug Cell Survival Fourteen new compounds were isolated from marine-derived Streptomyces sp. DS52, including 12 pyrimidine nucleosides (1-12), 1 benzoic acid derivative (13), and 1 dipyridine derivative (14). Additionally, 28 known compounds (15-42) were identified. The structures of all compounds were elucidated through extensive analysis of nuclear magnetic resonance spectroscopic and high-resolution electrospray ionization mass spectroscopy data. Electronic circular dichroism (ECD) calculations were employed to investigate the configurations of compounds 1, 2, and 4-13. Bioactivity evaluations of all of the compounds showed that compound 41 exhibited significant cytotoxicity against the HCT-116 and MDA-MB-231 human cancer cell lines with IC values of 0.73 ± 0.06 and 1.11 ± 0.06 µM, respectively. Notably, compounds 6, 7, 9, 11, 15, 33-38, 41, and 42 exhibited cytotoxicity against HCT-116 human colon cancer cell lines and MDA-MB-231 human breast cancer cell lines, with IC values ranging from 0.73 ± 0.06 to 17.44 ± 0.53 µM and from 1.11 ± 0.06 to 18.51 ± 3.07 µM, respectively. |
| format | Artículo científico |
| id | pubmed_39601488 |
| institution | PubMed |
| language | en |
| publishDate | 2025 |
| publisher | Chemistry & biodiversity |
| record_format | pubmed |
| spellingShingle | Pyrimidine Nucleosides, Benzoic Acid Derivative, and Bipyridine From the Marine-Derived Streptomyces Sp. DS52. Xia, Meng-de Fang, Jie-Bin Huang, Yun Chen, Shuang Ma, Zhong-Jun Humans Streptomyces Drug Screening Assays, Antitumor Antineoplastic Agents Cell Line, Tumor Pyrimidine Nucleosides Molecular Structure Structure-Activity Relationship Cell Proliferation Benzoic Acid Dose-Response Relationship, Drug Cell Survival Pyrimidine Nucleosides, Benzoic Acid Derivative, and Bipyridine From the Marine-Derived Streptomyces Sp. DS52. Xia, Meng-de Fang, Jie-Bin Huang, Yun Chen, Shuang Ma, Zhong-Jun Humans Streptomyces Drug Screening Assays, Antitumor Antineoplastic Agents Cell Line, Tumor Pyrimidine Nucleosides Molecular Structure Structure-Activity Relationship Cell Proliferation Benzoic Acid Dose-Response Relationship, Drug Cell Survival Fourteen new compounds were isolated from marine-derived Streptomyces sp. DS52, including 12 pyrimidine nucleosides (1-12), 1 benzoic acid derivative (13), and 1 dipyridine derivative (14). Additionally, 28 known compounds (15-42) were identified. The structures of all compounds were elucidated through extensive analysis of nuclear magnetic resonance spectroscopic and high-resolution electrospray ionization mass spectroscopy data. Electronic circular dichroism (ECD) calculations were employed to investigate the configurations of compounds 1, 2, and 4-13. Bioactivity evaluations of all of the compounds showed that compound 41 exhibited significant cytotoxicity against the HCT-116 and MDA-MB-231 human cancer cell lines with IC values of 0.73 ± 0.06 and 1.11 ± 0.06 µM, respectively. Notably, compounds 6, 7, 9, 11, 15, 33-38, 41, and 42 exhibited cytotoxicity against HCT-116 human colon cancer cell lines and MDA-MB-231 human breast cancer cell lines, with IC values ranging from 0.73 ± 0.06 to 17.44 ± 0.53 µM and from 1.11 ± 0.06 to 18.51 ± 3.07 µM, respectively. |
| title | Pyrimidine Nucleosides, Benzoic Acid Derivative, and Bipyridine From the Marine-Derived Streptomyces Sp. DS52. |
| topic | Humans Streptomyces Drug Screening Assays, Antitumor Antineoplastic Agents Cell Line, Tumor Pyrimidine Nucleosides Molecular Structure Structure-Activity Relationship Cell Proliferation Benzoic Acid Dose-Response Relationship, Drug Cell Survival |
| url | https://pubmed.ncbi.nlm.nih.gov/39601488/ |