Cover Image

Pyrimidine Nucleosides, Benzoic Acid Derivative, and Bipyridine From the Marine-Derived Streptomyces Sp. DS52.

Fuente: PubMed

Saved in:

Bibliographic Details
Main Authors:	Xia, Meng-de, Fang, Jie-Bin, Huang, Yun, Chen, Shuang, Ma, Zhong-Jun
Format:	Artículo científico
Language:	en
Published:	Chemistry & biodiversity 2025
Subjects:	Humans Streptomyces Drug Screening Assays, Antitumor Antineoplastic Agents Cell Line, Tumor Pyrimidine Nucleosides Molecular Structure Structure-Activity Relationship Cell Proliferation Benzoic Acid Dose-Response Relationship, Drug Cell Survival
Online Access:	Acceder al recurso
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Sclerohumins G-L: Selective cytotoxic diterpenoids featuring a 4/9-fused ring system from the soft coral Sclerophytum humesi.
by: Luu, Phuong Vu, et al.
Published: (2026)

Ircindrimanes A-I, nine undescribed meroterpenoids with cytotoxic activities from the marine sponge Ircinia sp.
by: Zhang, Wenjie, et al.
Published: (2025)

Discovery of 4-(2-(methylamino)thiazol-5-yl)pyrimidin-2-amine derivatives as novel cyclin-dependent kinase 12 (CDK12) inhibitors for the treatment of esophageal squamous cell carcinoma.
by: Cao, Yin, et al.
Published: (2025)

Target Screening and Validation of the Antitumor Effect of Saponin Extract From Holothuria leucospilota.
by: Xu, Fuju, et al.
Published: (2025)

Preparation of mitochondria-targeted camptothecin derivatives for the imaging and antiproliferation of colorectal cancer.
by: Xu, Chenmeng, et al.
Published: (2025)

Design and Synthesis of Marine Sarocladione Derivatives with Potential Anticancer Activity.
by: Liu, Xiao-Mei, et al.
Published: (2026)

Synthesis of mitochondria-targeted podophyllotoxin derivatives for the imaging and antiproliferation of liver cancer.
by: Xu, Chenmeng, et al.
Published: (2026)

Identification of EEF1A1 as a therapeutic target in TNBC: Anticancer action of a novel Penicillide-derived inhibitor through ribosomal protein regulation.
by: Yu, Jing, et al.
Published: (2026)

Cytotoxicity, apoptosis, molecular docking, and molecular dynamics study of novel compounds of Sulfamide derivatives coupled with DHP scaffolds as potent inhibitors of the MCF-7, A549, SKOV-3, and EA. yh926 carcinoma cells.
by: Abdulrasool, Amjed, et al.
Published: (2026)

Oxalicpyridones A-D, 2-pyridone alkaloids from a marine-derived fungus Penicillium oxalicum suppressing proliferation and metastasis against small cell lung cancer.
by: Chen, Xiangliu, et al.
Published: (2026)

Anticancer Effects of Monacolin X Against Human Liver Cancer Cell Line: Exploring the Apoptosis Using AO/EB and DCFHDA Fluorescent Staining.
by: Jayaraman, Vennila, et al.
Published: (2025)

Integrating experimental findings and machine learning models to predict the anticancer potential of newly synthesized oversulfated fucoidan.
by: Kocabay, Samet, et al.
Published: (2026)

Discovery of novel thiosemicarbazone dimers as effective inhibitors of poly(ADP-ribose) polymerase-1 (PARP-1) for use in cancer therapy.
by: Wang, Lijun, et al.
Published: (2026)

Total syntheses of Kavaratamide A and 5--Kavaratamide A.
by: Ren, Tieshun, et al.
Published: (2025)

Chemical Evolution of Aplithianine Class of Serine/Threonine Kinase Inhibitors.
by: Du, Lin, et al.
Published: (2025)

Design, synthesis, and biological evaluation of N-(2-amino-phenyl)-5-(4-aryl- pyrimidin-2-yl) amino)-1H-indole-2-carboxamide derivatives as novel inhibitors of CDK9 and class I HDACs for cancer treatment.
by: Chen, Xiaohui, et al.
Published: (2025)

Marine Natural Product Chagosendine C Induces Cuproptosis in Colorectal Cancer Cells by Targeting FDX1.
by: Tao, Xiaoyu, et al.
Published: (2025)

Discovery of an orally bioavailable pyridone-based BRD4 inhibitor with potent antitumor efficacy in colorectal cancer.
by: Fang, Zhangyun, et al.
Published: (2026)

Novel Marine Fungus-Derived Mycophenolic Acids That Inhibit Acute Myeloid Leukemia Cell Proliferation.
by: Deng, Guangli, et al.
Published: (2026)

Biogenic gold nanoparticles synthesized from Caulerpa sertularioides: A green approach for antioxidant, antibacterial and anticancer applications.
by: Sivakumar, Vibitha Sri, et al.
Published: (2025)

Metabolic Blockade-Based Genome Mining of SCSIO 07745: Discovery and Biosynthetic Pathway of Aminoquinolinone Alkaloids Bearing 6/6/5 Tricyclic and 6/6/6/5 Tetracyclic Scaffolds.
by: Li, Kunlong, et al.
Published: (2025)

Total Synthesis of Nocarterphenyl A, 2-Dehydroxymethylnocarterphenyl A and Nocarterphenyl D Produced by Marine spp.
by: Xu, Quan, et al.
Published: (2025)

Prediction of newly synthesized heparin mimic's effects as heparanase inhibitor in cancer treatments via variational quantum neural networks.
by: Kocabay, Samet, et al.
Published: (2025)

Discovery of the First-in-Class Dual-Target ROCK/HDAC Inhibitor with Potent Antitumor Efficacy in Vivo That Trigger Antitumor Immunity.
by: Mao, Churu, et al.
Published: (2024)

Structure-Activity Relationship Study of Majusculamide D: Overcoming Metabolic Instability and Severe Toxicity with a Fluoro Analogue.
by: Zhao, Xiuhe, et al.
Published: (2024)

PPTase-Based Activation Unlocks New Anthraquinones from Marine-Derived sp. SCSIO 07396.
by: Li, Xiaohua, et al.
Published: (2026)

Shimojilide, a Potent and Selective Antiproliferative Cyclic Lipopeptide from a Marine Cyanobacterium sp.
by: Niiyama, Mizuho, et al.
Published: (2026)

New Phthalide Derivatives With Cardioprotective Effects From the Marine Fungus Diaporthe phaseolorum HZ-2.
by: Feng, Ran-Qi, et al.
Published: (2026)

Candindoles A and B, Heterozygous Terphenyl-Indole Alkaloids with Antifungal and Cytotoxic Activities from the Marine-Derived Fungus HNNU0546.
by: Liu, Yi-Yi, et al.
Published: (2025)

Antibacterial and Cytotoxic Decahydrofluorene-Class Alkaloids from the Marine-Derived Fungus sp. SCSIO 41512.
by: Ban, Zi-Wei, et al.
Published: (2026)

Picolinic Acid Derivatives and Biosynthetic Pathway from SDU-F549.
by: Chen, Liuhai, et al.
Published: (2026)

Tumor Microenvironment-Responsive Multinucleated Nanocomplexes Loaded with Carbon Dots for Combined Photothermal/Chemodynamic Therapy of Breast Cancer.
by: Zhu, Zihan, et al.
Published: (2025)

Suaeglaucin C: a new coumaronochromone isolated from .
by: Jia, Jia, et al.
Published: (2026)

Synthesis and biological activity of 1H-pyrrolo[3,2-g]isoquinolines as Haspin kinase inhibitors.
by: Malosse, Killian, et al.
Published: (2025)

Undescribed alkaloids, peptides and polyketides from marine sediment-derived fungus Aspergillus terreus PPS1.
by: Zheng, Yao-Yao, et al.
Published: (2025)

Aspirin-Inspired 6-O-Carboxymethyl-N-Acetylglucosamine: A potent antitumor agent with enhanced efficacy.
by: Qiao, Ziwen, et al.
Published: (2025)

SMART-assisted discovery of scalaranes from the marine sponge Lendenfeldia sp. and its anti-osteoclastogenesis activity.
by: Pham, Quoc-Vu, et al.
Published: (2026)

Antimicrobial and anticancer activity of Streptomyces ambofaciens (Myt 8) and S. globisporus ONU 1019 (Myt 11) secondary metabolites isolated from the Odesa Bay, the Black Sea: An in vitro study.
by: Potapenko, Kateryna, et al.
Published: (2025)

Isolation and Bioactivity of Natural Products from sp. MA37.
by: Maglangit, Fleurdeliz, et al.
Published: (2025)

Geodiamolide A, a Marine Sponge Depsipeptide, Halts Proliferation and Triggers Cell Death in Squamous Cell Carcinoma (A431, NMSC) In Vitro.
by: Rangel, Marisa, et al.
Published: (2026)