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| Main Authors: | , , , , , , , , |
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| Format: | Artículo científico |
| Language: | en |
| Published: |
Journal of natural products
2024
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| Subjects: | |
| Online Access: | https://pubmed.ncbi.nlm.nih.gov/39601657/ |
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Table of Contents:
- Cyclopeptide Avellanins D-O with Antimalarial Activity from the Mariana Trench Anemone-Derived MSC5. Li, Hao Chen, Yuling Tang, Bingqing Liu, Zhengjie Peng, Bo Li, Jiajun Gao, Han Wang, Sibao Li, Zhiyong Antimalarials Peptides, Cyclic Molecular Structure Animals Plasmodium falciparum Sea Anemones Marine microorganisms are a treasure trove of natural products, especially those in extreme marine environments, which may produce novel natural products. Herein, biosynthetic gene cluster analysis combined with an integrated metabolomic strategy incorporating matrix-assisted laser desorption ionization-time-of-flight mass spectrometry (MALDI-TOF MS), nuclear magnetic resonance (NMR), and liquid chromatography-mass spectrometry/mass spectrometry (LC-MS/MS) based Global Natural Products Social Molecular Networking (GNPS) was used to discover new compounds from the Mariana trench anemone-derived fungus MSC5. As a result, 12 new cyclic pentapeptides, avellanins D-O (-), were isolated, together with a known cyclic pentapeptide avellanin C (). All the structures and absolute configurations were elucidated using NMR, mass spectrometry, X-ray diffraction analysis, and Marfey's method. A plausible biosynthetic pathway for the avellanins was proposed based on the gene cluster analysis of MSC5. Bioassay revealed that compound exhibited potent antimalarial activity with an IC value of 0.19 ± 0.09 μM.