Research progress and immunological insights of shrimp allergens.
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| Autores principales: | , , , |
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| Formato: | Artículo científico |
| Lenguaje: | en |
| Publicado: |
Fish & shellfish immunology
2025
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| _version_ | 1868266275360210946 |
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| author | Xu, Bao-Liang Wang, Yuan-Yuan Chu, Xin-Lei Dong, Chun-Ming |
| author_facet | Xu, Bao-Liang Wang, Yuan-Yuan Chu, Xin-Lei Dong, Chun-Ming Xu, Bao-Liang Wang, Yuan-Yuan Chu, Xin-Lei Dong, Chun-Ming |
| collection | PubMed - marine biology |
| contents | Research progress and immunological insights of shrimp allergens. Xu, Bao-Liang Wang, Yuan-Yuan Chu, Xin-Lei Dong, Chun-Ming Allergens Animals Shellfish Hypersensitivity Penaeidae Arthropod Proteins Allergic diseases have become a major health issue in the 21st century. The FAO has pinpointed the eight most prevalent allergens worldwide, with shrimp allergy attracting global concern due to its escalating incidence. This review delves into the current knowledge of shrimp allergen types and traits, immune response mechanisms, advancements in cross-reactivity research, and breakthroughs in diagnostic and therapeutic methods. It highlights the variety of shrimp allergens, such as tropomyosin and arginine kinase, and concentrates on IgE-mediated immediate hypersensitivity reactions, involving mast cells and basophils, alongside the role of T cells and cytokines in non-IgE-mediated delayed hypersensitivity reactions. The exploration of cross-reactivity underscores the connection between shrimp allergy and allergies to other animals. Utilizing bioinformatics tools, including homology analysis, epitope prediction, and molecular modeling, has enhanced our comprehension of allergen molecular features. In treatment and diagnosis, innovative approaches like immunotherapy and gene editing technology hold potential to decrease allergic sensitivity, while emerging reduction techniques like heat treatment and enzymatic hydrolysis offer new strategies for the prevention and management of food allergies. The evolution of allergen detection and purification technologies has spurred innovation in testing methodologies, encompassing traditional in vivo tests like SPT and DBPCFC, in addition to a range of other techniques such as immunoassays, biochip technology, PCR, and histamine release experiments, propelling the instantaneous and accurate identification of allergens. These scientific breakthroughs not only expand our understanding of shrimp allergen biology but also lay the foundation for developing more effective allergy prevention and control strategies. |
| format | Artículo científico |
| id | pubmed_39608732 |
| institution | PubMed |
| language | en |
| publishDate | 2025 |
| publisher | Fish & shellfish immunology |
| record_format | pubmed |
| spellingShingle | Research progress and immunological insights of shrimp allergens. Xu, Bao-Liang Wang, Yuan-Yuan Chu, Xin-Lei Dong, Chun-Ming Allergens Animals Shellfish Hypersensitivity Penaeidae Arthropod Proteins Research progress and immunological insights of shrimp allergens. Xu, Bao-Liang Wang, Yuan-Yuan Chu, Xin-Lei Dong, Chun-Ming Allergens Animals Shellfish Hypersensitivity Penaeidae Arthropod Proteins Allergic diseases have become a major health issue in the 21st century. The FAO has pinpointed the eight most prevalent allergens worldwide, with shrimp allergy attracting global concern due to its escalating incidence. This review delves into the current knowledge of shrimp allergen types and traits, immune response mechanisms, advancements in cross-reactivity research, and breakthroughs in diagnostic and therapeutic methods. It highlights the variety of shrimp allergens, such as tropomyosin and arginine kinase, and concentrates on IgE-mediated immediate hypersensitivity reactions, involving mast cells and basophils, alongside the role of T cells and cytokines in non-IgE-mediated delayed hypersensitivity reactions. The exploration of cross-reactivity underscores the connection between shrimp allergy and allergies to other animals. Utilizing bioinformatics tools, including homology analysis, epitope prediction, and molecular modeling, has enhanced our comprehension of allergen molecular features. In treatment and diagnosis, innovative approaches like immunotherapy and gene editing technology hold potential to decrease allergic sensitivity, while emerging reduction techniques like heat treatment and enzymatic hydrolysis offer new strategies for the prevention and management of food allergies. The evolution of allergen detection and purification technologies has spurred innovation in testing methodologies, encompassing traditional in vivo tests like SPT and DBPCFC, in addition to a range of other techniques such as immunoassays, biochip technology, PCR, and histamine release experiments, propelling the instantaneous and accurate identification of allergens. These scientific breakthroughs not only expand our understanding of shrimp allergen biology but also lay the foundation for developing more effective allergy prevention and control strategies. |
| title | Research progress and immunological insights of shrimp allergens. |
| topic | Allergens Animals Shellfish Hypersensitivity Penaeidae Arthropod Proteins |
| url | https://pubmed.ncbi.nlm.nih.gov/39608732/ |