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| Main Authors: | , , , , , , , , , , |
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| Format: | Artículo científico |
| Language: | en |
| Published: |
Environmental toxicology and pharmacology
2025
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| Subjects: | |
| Online Access: | https://pubmed.ncbi.nlm.nih.gov/39626850/ |
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| _version_ | 1868266272962117635 |
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| author | De Marco, Giuseppe Cristaldi, Antonio Eliso, Maria Concetta Oliveri Conti, Gea Galati, Mariachiara Billè, Barbara Terranova, Mery Parrino, Vincenzo Cappello, Tiziana Ferrante, Margherita Maisano, Maria |
| author_facet | De Marco, Giuseppe Cristaldi, Antonio Eliso, Maria Concetta Oliveri Conti, Gea Galati, Mariachiara Billè, Barbara Terranova, Mery Parrino, Vincenzo Cappello, Tiziana Ferrante, Margherita Maisano, Maria De Marco, Giuseppe Cristaldi, Antonio Eliso, Maria Concetta Oliveri Conti, Gea Galati, Mariachiara Billè, Barbara Terranova, Mery Parrino, Vincenzo Cappello, Tiziana Ferrante, Margherita Maisano, Maria |
| collection | PubMed - marine biology |
| contents | Cellular pathway disturbances elicited by realistic dexamethasone concentrations in gills of mussel Mytilus galloprovincialis as assessed by a multi-biomarker approach. De Marco, Giuseppe Cristaldi, Antonio Eliso, Maria Concetta Oliveri Conti, Gea Galati, Mariachiara Billè, Barbara Terranova, Mery Parrino, Vincenzo Cappello, Tiziana Ferrante, Margherita Maisano, Maria Animals Dexamethasone Mytilus Gills Water Pollutants, Chemical Biomarkers Lipid Peroxidation Anti-Inflammatory Agents Hemocytes The growing usage of glucocorticoids for a variety of diseases raises concerns since these drugs, including the anti-inflammatory dexamethasone (DEX), are frequently found in the environment. The impact of DEX was evaluated on mussels Mytilus galloprovincialis (Lamarck, 1819) by exposure to environmental concentrations (C1: 4 ng/L; C2: 40 ng/L; C3: 400 ng/L; C4: 2000 ng/L), and sampling at 3 (T3), 6 (T6), and 12 (T12) days. A multi-biomarker approach was applied on gills, involved in gas exchange, feed filtering, and osmoregulation. A dose- and time-dependent uptake of DEX was recorded, besides haemocyte infiltration, increased neutral and acid mucopolysaccharides, and a general pro-oxidant effect witnessed by lipid peroxidation and altered antioxidant system. Metabolomics revealed rise in protein turnover and energy demand by fluctuations in free amino acids (alanine, glycine) and energy-related metabolites (succinate, ATP/ADP). It is necessary to reduce DEX dosage from the environment by recovery strategies and effective eco-pharmacovigilance programs. |
| format | Artículo científico |
| id | pubmed_39626850 |
| institution | PubMed |
| language | en |
| publishDate | 2025 |
| publisher | Environmental toxicology and pharmacology |
| record_format | pubmed |
| spellingShingle | Cellular pathway disturbances elicited by realistic dexamethasone concentrations in gills of mussel Mytilus galloprovincialis as assessed by a multi-biomarker approach. De Marco, Giuseppe Cristaldi, Antonio Eliso, Maria Concetta Oliveri Conti, Gea Galati, Mariachiara Billè, Barbara Terranova, Mery Parrino, Vincenzo Cappello, Tiziana Ferrante, Margherita Maisano, Maria Animals Dexamethasone Mytilus Gills Water Pollutants, Chemical Biomarkers Lipid Peroxidation Anti-Inflammatory Agents Hemocytes Cellular pathway disturbances elicited by realistic dexamethasone concentrations in gills of mussel Mytilus galloprovincialis as assessed by a multi-biomarker approach. De Marco, Giuseppe Cristaldi, Antonio Eliso, Maria Concetta Oliveri Conti, Gea Galati, Mariachiara Billè, Barbara Terranova, Mery Parrino, Vincenzo Cappello, Tiziana Ferrante, Margherita Maisano, Maria Animals Dexamethasone Mytilus Gills Water Pollutants, Chemical Biomarkers Lipid Peroxidation Anti-Inflammatory Agents Hemocytes The growing usage of glucocorticoids for a variety of diseases raises concerns since these drugs, including the anti-inflammatory dexamethasone (DEX), are frequently found in the environment. The impact of DEX was evaluated on mussels Mytilus galloprovincialis (Lamarck, 1819) by exposure to environmental concentrations (C1: 4 ng/L; C2: 40 ng/L; C3: 400 ng/L; C4: 2000 ng/L), and sampling at 3 (T3), 6 (T6), and 12 (T12) days. A multi-biomarker approach was applied on gills, involved in gas exchange, feed filtering, and osmoregulation. A dose- and time-dependent uptake of DEX was recorded, besides haemocyte infiltration, increased neutral and acid mucopolysaccharides, and a general pro-oxidant effect witnessed by lipid peroxidation and altered antioxidant system. Metabolomics revealed rise in protein turnover and energy demand by fluctuations in free amino acids (alanine, glycine) and energy-related metabolites (succinate, ATP/ADP). It is necessary to reduce DEX dosage from the environment by recovery strategies and effective eco-pharmacovigilance programs. |
| title | Cellular pathway disturbances elicited by realistic dexamethasone concentrations in gills of mussel Mytilus galloprovincialis as assessed by a multi-biomarker approach. |
| topic | Animals Dexamethasone Mytilus Gills Water Pollutants, Chemical Biomarkers Lipid Peroxidation Anti-Inflammatory Agents Hemocytes |
| url | https://pubmed.ncbi.nlm.nih.gov/39626850/ |