White spot syndrome virus IE1 protein blocks the integrin-FAK signaling to enhance viral infection in shrimp.
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| Main Authors: | , , , , , , , |
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| Format: | Artículo científico |
| Language: | en |
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Fish & shellfish immunology
2025
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| _version_ | 1868266272951631872 |
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| author | Lu, Kaiyu Chen, Xiyu Zhang, Huimin Zhu, Jinghua Zhao, Yongzhen Chen, Xiuli Zhang, Yueling Yao, Defu |
| author_facet | Lu, Kaiyu Chen, Xiyu Zhang, Huimin Zhu, Jinghua Zhao, Yongzhen Chen, Xiuli Zhang, Yueling Yao, Defu Lu, Kaiyu Chen, Xiyu Zhang, Huimin Zhu, Jinghua Zhao, Yongzhen Chen, Xiuli Zhang, Yueling Yao, Defu |
| collection | PubMed - marine biology |
| contents | White spot syndrome virus IE1 protein blocks the integrin-FAK signaling to enhance viral infection in shrimp. Lu, Kaiyu Chen, Xiyu Zhang, Huimin Zhu, Jinghua Zhao, Yongzhen Chen, Xiuli Zhang, Yueling Yao, Defu Animals Penaeidae White spot syndrome virus 1 Signal Transduction Arthropod Proteins Integrins Cell Adhesion DNA viruses commonly utilize immediate-early proteins to manipulate cellular signaling pathways in order to facilitate their infection. Our previous research has suggested that IE1, an immediate-early protein encoded by the white spot syndrome virus (WSSV), may modulate the shrimp integrin-FAK signaling pathway. However, the specific molecular mechanism and role of IE1 in regulating this signaling pathway remain unclear. In this study, we demonstrated that IE1 competes for binding to the cytoplasmic tail of Penaeus vannamei integrin-α5, resulting in the inhibition of the integrin-α5-FAK interaction, thereby suppressing FAK activation and cell adhesion. Furthermore, we observed a significant increase in the expression of P. vannamei integrin-α5 and FAK following WSSV infection. Additionally, knockdown of integrin-α5 or FAK through RNA interference has been shown to reduce cell adhesion and enhance WSSV infection. In conclusion, our findings reveal that IE1 disrupts integrin-FAK signaling to inhibit cell adhesion, ultimately promoting WSSV infection in shrimp. |
| format | Artículo científico |
| id | pubmed_39637952 |
| institution | PubMed |
| language | en |
| publishDate | 2025 |
| publisher | Fish & shellfish immunology |
| record_format | pubmed |
| spellingShingle | White spot syndrome virus IE1 protein blocks the integrin-FAK signaling to enhance viral infection in shrimp. Lu, Kaiyu Chen, Xiyu Zhang, Huimin Zhu, Jinghua Zhao, Yongzhen Chen, Xiuli Zhang, Yueling Yao, Defu Animals Penaeidae White spot syndrome virus 1 Signal Transduction Arthropod Proteins Integrins Cell Adhesion White spot syndrome virus IE1 protein blocks the integrin-FAK signaling to enhance viral infection in shrimp. Lu, Kaiyu Chen, Xiyu Zhang, Huimin Zhu, Jinghua Zhao, Yongzhen Chen, Xiuli Zhang, Yueling Yao, Defu Animals Penaeidae White spot syndrome virus 1 Signal Transduction Arthropod Proteins Integrins Cell Adhesion DNA viruses commonly utilize immediate-early proteins to manipulate cellular signaling pathways in order to facilitate their infection. Our previous research has suggested that IE1, an immediate-early protein encoded by the white spot syndrome virus (WSSV), may modulate the shrimp integrin-FAK signaling pathway. However, the specific molecular mechanism and role of IE1 in regulating this signaling pathway remain unclear. In this study, we demonstrated that IE1 competes for binding to the cytoplasmic tail of Penaeus vannamei integrin-α5, resulting in the inhibition of the integrin-α5-FAK interaction, thereby suppressing FAK activation and cell adhesion. Furthermore, we observed a significant increase in the expression of P. vannamei integrin-α5 and FAK following WSSV infection. Additionally, knockdown of integrin-α5 or FAK through RNA interference has been shown to reduce cell adhesion and enhance WSSV infection. In conclusion, our findings reveal that IE1 disrupts integrin-FAK signaling to inhibit cell adhesion, ultimately promoting WSSV infection in shrimp. |
| title | White spot syndrome virus IE1 protein blocks the integrin-FAK signaling to enhance viral infection in shrimp. |
| topic | Animals Penaeidae White spot syndrome virus 1 Signal Transduction Arthropod Proteins Integrins Cell Adhesion |
| url | https://pubmed.ncbi.nlm.nih.gov/39637952/ |