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| Autores principales: | , , , , , , |
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| Formato: | Artículo científico |
| Lenguaje: | en |
| Publicado: |
Chemistry & biodiversity
2025
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| Materias: | |
| Acceso en línea: | https://pubmed.ncbi.nlm.nih.gov/39638771/ |
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| _version_ | 1868266272949534722 |
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| author | Zhang, Yan Cao, Wei Liu, Xin Ma, Zhi-Heng Li, Pei-Hai Chen, Hao Fan, Ya-Qin |
| author_facet | Zhang, Yan Cao, Wei Liu, Xin Ma, Zhi-Heng Li, Pei-Hai Chen, Hao Fan, Ya-Qin Zhang, Yan Cao, Wei Liu, Xin Ma, Zhi-Heng Li, Pei-Hai Chen, Hao Fan, Ya-Qin |
| collection | PubMed - marine biology |
| contents | A New Methylbutyric Acid Derivative With Pro-Angiogenesis Activity From the Mangrove Fungus Penicillium polonicum M-3. Zhang, Yan Cao, Wei Liu, Xin Ma, Zhi-Heng Li, Pei-Hai Chen, Hao Fan, Ya-Qin Penicillium Zebrafish Animals Angiogenesis Inducing Agents Molecular Structure Animals, Genetically Modified Angiogenesis A new methylbutyric acid derivative, penianoic acid A (1), along with fifteen known compounds (2-16), was isolated and identified from the culture extract of Penicillium polonicum M-3 sourced from Malaysian mangrove root soil. Their structures were determined by detailed spectroscopic analysis of NMR and MS data and quantum chemical calculations of ECD and NMR (with DP4+ probability analysis). The isolated compounds were evaluated for pro-angiogenesis activity using zebrafish in vivo model. Compounds 1, 3, 4, 6-10, and 12-15 showed potent in pro-angiogenic activity in transgenic zebrafish. |
| format | Artículo científico |
| id | pubmed_39638771 |
| institution | PubMed |
| language | en |
| publishDate | 2025 |
| publisher | Chemistry & biodiversity |
| record_format | pubmed |
| spellingShingle | A New Methylbutyric Acid Derivative With Pro-Angiogenesis Activity From the Mangrove Fungus Penicillium polonicum M-3. Zhang, Yan Cao, Wei Liu, Xin Ma, Zhi-Heng Li, Pei-Hai Chen, Hao Fan, Ya-Qin Penicillium Zebrafish Animals Angiogenesis Inducing Agents Molecular Structure Animals, Genetically Modified Angiogenesis A New Methylbutyric Acid Derivative With Pro-Angiogenesis Activity From the Mangrove Fungus Penicillium polonicum M-3. Zhang, Yan Cao, Wei Liu, Xin Ma, Zhi-Heng Li, Pei-Hai Chen, Hao Fan, Ya-Qin Penicillium Zebrafish Animals Angiogenesis Inducing Agents Molecular Structure Animals, Genetically Modified Angiogenesis A new methylbutyric acid derivative, penianoic acid A (1), along with fifteen known compounds (2-16), was isolated and identified from the culture extract of Penicillium polonicum M-3 sourced from Malaysian mangrove root soil. Their structures were determined by detailed spectroscopic analysis of NMR and MS data and quantum chemical calculations of ECD and NMR (with DP4+ probability analysis). The isolated compounds were evaluated for pro-angiogenesis activity using zebrafish in vivo model. Compounds 1, 3, 4, 6-10, and 12-15 showed potent in pro-angiogenic activity in transgenic zebrafish. |
| title | A New Methylbutyric Acid Derivative With Pro-Angiogenesis Activity From the Mangrove Fungus Penicillium polonicum M-3. |
| topic | Penicillium Zebrafish Animals Angiogenesis Inducing Agents Molecular Structure Animals, Genetically Modified Angiogenesis |
| url | https://pubmed.ncbi.nlm.nih.gov/39638771/ |