Total syntheses of Kavaratamide A and 5--Kavaratamide A.
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| Hauptverfasser: | , , , |
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| Format: | Artículo científico |
| Sprache: | en |
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Organic & biomolecular chemistry
2025
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| _version_ | 1868266272949534720 |
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| author | Ren, Tieshun Lv, Ke Hu, Fangzhong Chen, Yue |
| author_facet | Ren, Tieshun Lv, Ke Hu, Fangzhong Chen, Yue Ren, Tieshun Lv, Ke Hu, Fangzhong Chen, Yue |
| collection | PubMed - marine biology |
| contents | Total syntheses of Kavaratamide A and 5--Kavaratamide A. Ren, Tieshun Lv, Ke Hu, Fangzhong Chen, Yue Humans Depsipeptides Cyanobacteria Antineoplastic Agents Cell Line, Tumor Molecular Structure Drug Screening Assays, Antitumor The total synthesis of Kavaratamide A, a new Linear Lipodepsipeptide from the Marine Cyanobacterium was achieved by assembling the side chain in stage through condensation coupling, carbon-chain extension, Steglich esterification and Evans aldol reaction. In addition, total synthesis of Kavaratamide A's isomer, 5--kavaratamide A, is also successfully achieved. Cytotoxicity test suggested that Kavaratamide A and 5--Kavaratamide A have a moderate bioactivity against cancer cells. |
| format | Artículo científico |
| id | pubmed_39639786 |
| institution | PubMed |
| language | en |
| publishDate | 2025 |
| publisher | Organic & biomolecular chemistry |
| record_format | pubmed |
| spellingShingle | Total syntheses of Kavaratamide A and 5--Kavaratamide A. Ren, Tieshun Lv, Ke Hu, Fangzhong Chen, Yue Humans Depsipeptides Cyanobacteria Antineoplastic Agents Cell Line, Tumor Molecular Structure Drug Screening Assays, Antitumor Total syntheses of Kavaratamide A and 5--Kavaratamide A. Ren, Tieshun Lv, Ke Hu, Fangzhong Chen, Yue Humans Depsipeptides Cyanobacteria Antineoplastic Agents Cell Line, Tumor Molecular Structure Drug Screening Assays, Antitumor The total synthesis of Kavaratamide A, a new Linear Lipodepsipeptide from the Marine Cyanobacterium was achieved by assembling the side chain in stage through condensation coupling, carbon-chain extension, Steglich esterification and Evans aldol reaction. In addition, total synthesis of Kavaratamide A's isomer, 5--kavaratamide A, is also successfully achieved. Cytotoxicity test suggested that Kavaratamide A and 5--Kavaratamide A have a moderate bioactivity against cancer cells. |
| title | Total syntheses of Kavaratamide A and 5--Kavaratamide A. |
| topic | Humans Depsipeptides Cyanobacteria Antineoplastic Agents Cell Line, Tumor Molecular Structure Drug Screening Assays, Antitumor |
| url | https://pubmed.ncbi.nlm.nih.gov/39639786/ |