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| Main Authors: | , , , |
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| Format: | Artículo científico |
| Language: | en |
| Published: |
Organic & biomolecular chemistry
2025
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| Subjects: | |
| Online Access: | https://pubmed.ncbi.nlm.nih.gov/39639786/ |
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Table of Contents:
- Total syntheses of Kavaratamide A and 5--Kavaratamide A. Ren, Tieshun Lv, Ke Hu, Fangzhong Chen, Yue Humans Depsipeptides Cyanobacteria Antineoplastic Agents Cell Line, Tumor Molecular Structure Drug Screening Assays, Antitumor The total synthesis of Kavaratamide A, a new Linear Lipodepsipeptide from the Marine Cyanobacterium was achieved by assembling the side chain in stage through condensation coupling, carbon-chain extension, Steglich esterification and Evans aldol reaction. In addition, total synthesis of Kavaratamide A's isomer, 5--kavaratamide A, is also successfully achieved. Cytotoxicity test suggested that Kavaratamide A and 5--Kavaratamide A have a moderate bioactivity against cancer cells.