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| Main Authors: | , , , , , , , , , |
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| Format: | Artículo científico |
| Language: | en |
| Published: |
Ecotoxicology and environmental safety
2025
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| Subjects: | |
| Online Access: | https://pubmed.ncbi.nlm.nih.gov/39647374/ |
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| _version_ | 1868266270333337602 |
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| author | Liu, Liuqingqing Li, Xinyao Luo, Xianxiang Wang, Xiao Liu, Linjia Yuan, Zixi Sun, Cuizhu Zheng, Hao Xu, Elvis Genbo Li, Fengmin |
| author_facet | Liu, Liuqingqing Li, Xinyao Luo, Xianxiang Wang, Xiao Liu, Linjia Yuan, Zixi Sun, Cuizhu Zheng, Hao Xu, Elvis Genbo Li, Fengmin Liu, Liuqingqing Li, Xinyao Luo, Xianxiang Wang, Xiao Liu, Linjia Yuan, Zixi Sun, Cuizhu Zheng, Hao Xu, Elvis Genbo Li, Fengmin |
| collection | PubMed - marine biology |
| contents | Phthalates esters disrupt demersal fish behavior: Unveiling the brain-gut axis impact. Liu, Liuqingqing Li, Xinyao Luo, Xianxiang Wang, Xiao Liu, Linjia Yuan, Zixi Sun, Cuizhu Zheng, Hao Xu, Elvis Genbo Li, Fengmin Animals Phthalic Acids Brain Behavior, Animal Water Pollutants, Chemical Esters Fishes Plasticizers Diethylhexyl Phthalate Dibutyl Phthalate The widespread use of plasticizers like phthalate esters (PAEs) has led to environmental and health concerns. The neurobehavioral toxicity of these compounds in marine environments, particularly regulated by the "brain-gut" axis, remains unclear, especially concerning wild demersal fish of high ecological value. Our investigation into the behavioral effects of three common PAEs, i.e., dimethyl phthalate (DMP), di-n-butyl phthalate (DBP), and di(2-ethylhexyl) phthalate (DEHP), and their molecular mechanisms on juvenile Sebastes schlegelii, revealed alarming results from molecular to population levels. After a 20-day foodborne exposure at a low marine environmental concentration (1.0 μg g), we observed that all three PAEs significantly increased the thigmotaxis (behavioral tendency to stay close to physical boundaries) and mobility of juvenile fish by 28.2-59.4 % and 23.3-74.5 %, respectively, indicating anxiety-like behavior of fish. DEHP exhibited the most pronounced effects, followed by DBP and DMP. PAEs accumulated in the juvenile fish in the order of brain > liver > gut > muscle, with DEHP showing the highest brain concentrations (23.2 ± 2.98 μg g). This accumulation led to oxidative damage, inflammatory responses, and neurodegenerative changes in the optic tectum, resulting in cholinergic system dysfunction. In the gut, PAEs caused inflammatory lesions, disrupted the gut barrier, and altered the gut microbiome, exacerbating the neurotoxicity via "brain-gut" communication. These findings underscore the significant neurobehavioral toxicity of PAEs, emphasizing their critical impact on fish behavior. We also stress the crucial need for further research on fish and other marine species beyond the laboratory scale to fully understand the broader implications of PAE exposure in marine ecosystems and to guide future conservation efforts. |
| format | Artículo científico |
| id | pubmed_39647374 |
| institution | PubMed |
| language | en |
| publishDate | 2025 |
| publisher | Ecotoxicology and environmental safety |
| record_format | pubmed |
| spellingShingle | Phthalates esters disrupt demersal fish behavior: Unveiling the brain-gut axis impact. Liu, Liuqingqing Li, Xinyao Luo, Xianxiang Wang, Xiao Liu, Linjia Yuan, Zixi Sun, Cuizhu Zheng, Hao Xu, Elvis Genbo Li, Fengmin Animals Phthalic Acids Brain Behavior, Animal Water Pollutants, Chemical Esters Fishes Plasticizers Diethylhexyl Phthalate Dibutyl Phthalate Phthalates esters disrupt demersal fish behavior: Unveiling the brain-gut axis impact. Liu, Liuqingqing Li, Xinyao Luo, Xianxiang Wang, Xiao Liu, Linjia Yuan, Zixi Sun, Cuizhu Zheng, Hao Xu, Elvis Genbo Li, Fengmin Animals Phthalic Acids Brain Behavior, Animal Water Pollutants, Chemical Esters Fishes Plasticizers Diethylhexyl Phthalate Dibutyl Phthalate The widespread use of plasticizers like phthalate esters (PAEs) has led to environmental and health concerns. The neurobehavioral toxicity of these compounds in marine environments, particularly regulated by the "brain-gut" axis, remains unclear, especially concerning wild demersal fish of high ecological value. Our investigation into the behavioral effects of three common PAEs, i.e., dimethyl phthalate (DMP), di-n-butyl phthalate (DBP), and di(2-ethylhexyl) phthalate (DEHP), and their molecular mechanisms on juvenile Sebastes schlegelii, revealed alarming results from molecular to population levels. After a 20-day foodborne exposure at a low marine environmental concentration (1.0 μg g), we observed that all three PAEs significantly increased the thigmotaxis (behavioral tendency to stay close to physical boundaries) and mobility of juvenile fish by 28.2-59.4 % and 23.3-74.5 %, respectively, indicating anxiety-like behavior of fish. DEHP exhibited the most pronounced effects, followed by DBP and DMP. PAEs accumulated in the juvenile fish in the order of brain > liver > gut > muscle, with DEHP showing the highest brain concentrations (23.2 ± 2.98 μg g). This accumulation led to oxidative damage, inflammatory responses, and neurodegenerative changes in the optic tectum, resulting in cholinergic system dysfunction. In the gut, PAEs caused inflammatory lesions, disrupted the gut barrier, and altered the gut microbiome, exacerbating the neurotoxicity via "brain-gut" communication. These findings underscore the significant neurobehavioral toxicity of PAEs, emphasizing their critical impact on fish behavior. We also stress the crucial need for further research on fish and other marine species beyond the laboratory scale to fully understand the broader implications of PAE exposure in marine ecosystems and to guide future conservation efforts. |
| title | Phthalates esters disrupt demersal fish behavior: Unveiling the brain-gut axis impact. |
| topic | Animals Phthalic Acids Brain Behavior, Animal Water Pollutants, Chemical Esters Fishes Plasticizers Diethylhexyl Phthalate Dibutyl Phthalate |
| url | https://pubmed.ncbi.nlm.nih.gov/39647374/ |