Marine mussel metabolism under stress: Dual effects of nanoplastics and coastal hypoxia.
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| Autores principales: | , , , , , |
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| Formato: | Artículo científico |
| Lenguaje: | en |
| Publicado: |
Journal of hazardous materials
2025
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| _version_ | 1868266268233039872 |
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| author | Wang, Xin Zhang, Tianyu Yang, Dinglong Xu, Elvis Genbo Javidpour, Jamileh Zhao, Jianmin |
| author_facet | Wang, Xin Zhang, Tianyu Yang, Dinglong Xu, Elvis Genbo Javidpour, Jamileh Zhao, Jianmin Wang, Xin Zhang, Tianyu Yang, Dinglong Xu, Elvis Genbo Javidpour, Jamileh Zhao, Jianmin |
| collection | PubMed - marine biology |
| contents | Marine mussel metabolism under stress: Dual effects of nanoplastics and coastal hypoxia. Wang, Xin Zhang, Tianyu Yang, Dinglong Xu, Elvis Genbo Javidpour, Jamileh Zhao, Jianmin Animals Mytilus Water Pollutants, Chemical Energy Metabolism Microplastics Oxygen Polystyrenes Stress, Physiological Hypoxia Oxidation-Reduction Citric Acid Cycle Emerging challenges in marine environments include nanoplastics (NPs) pollution and coastal hypoxia. Although NPs toxicity in marine organisms is being increasingly documented, the complex interactions between coastal hypoxia and NPs remain largely unexplored. This study investigated the dual effects of polystyrene nanoplastics and different oxygen levels on redox homeostasis and bioenergetics in the marine model organism Mytilus galloprovincialis. Both NPs and hypoxia significantly disrupted redox homeostasis in mussels. Exposure to NPs alone increased electron transport chain activity, whereas exposure to hypoxia alone and co-exposure significantly reduced this activity. Metabolomic analysis showed that NPs primarily affected the pentose phosphate pathway (PPP), tricarboxylic acid (TCA) cycle, and amino acid metabolism; hypoxia exposure alone disrupted the TCA cycle, pyruvate metabolism, and glycolysis/gluconeogenesis, whereas combined exposure notably altered the TCA cycle, PPP, and sugar interconversion. This suggests that regulating these pathways would help mussels cope with the combined environmental stress. Furthermore, co-exposure severely disrupted redox homeostasis and energy metabolism in mussels, suggesting that hypoxia exacerbates NPs toxicity. We believe that these new findings would enhance our understanding of the compounded ecological risks posed by NPs in the context of climate change. |
| format | Artículo científico |
| id | pubmed_39673953 |
| institution | PubMed |
| language | en |
| publishDate | 2025 |
| publisher | Journal of hazardous materials |
| record_format | pubmed |
| spellingShingle | Marine mussel metabolism under stress: Dual effects of nanoplastics and coastal hypoxia. Wang, Xin Zhang, Tianyu Yang, Dinglong Xu, Elvis Genbo Javidpour, Jamileh Zhao, Jianmin Animals Mytilus Water Pollutants, Chemical Energy Metabolism Microplastics Oxygen Polystyrenes Stress, Physiological Hypoxia Oxidation-Reduction Citric Acid Cycle Marine mussel metabolism under stress: Dual effects of nanoplastics and coastal hypoxia. Wang, Xin Zhang, Tianyu Yang, Dinglong Xu, Elvis Genbo Javidpour, Jamileh Zhao, Jianmin Animals Mytilus Water Pollutants, Chemical Energy Metabolism Microplastics Oxygen Polystyrenes Stress, Physiological Hypoxia Oxidation-Reduction Citric Acid Cycle Emerging challenges in marine environments include nanoplastics (NPs) pollution and coastal hypoxia. Although NPs toxicity in marine organisms is being increasingly documented, the complex interactions between coastal hypoxia and NPs remain largely unexplored. This study investigated the dual effects of polystyrene nanoplastics and different oxygen levels on redox homeostasis and bioenergetics in the marine model organism Mytilus galloprovincialis. Both NPs and hypoxia significantly disrupted redox homeostasis in mussels. Exposure to NPs alone increased electron transport chain activity, whereas exposure to hypoxia alone and co-exposure significantly reduced this activity. Metabolomic analysis showed that NPs primarily affected the pentose phosphate pathway (PPP), tricarboxylic acid (TCA) cycle, and amino acid metabolism; hypoxia exposure alone disrupted the TCA cycle, pyruvate metabolism, and glycolysis/gluconeogenesis, whereas combined exposure notably altered the TCA cycle, PPP, and sugar interconversion. This suggests that regulating these pathways would help mussels cope with the combined environmental stress. Furthermore, co-exposure severely disrupted redox homeostasis and energy metabolism in mussels, suggesting that hypoxia exacerbates NPs toxicity. We believe that these new findings would enhance our understanding of the compounded ecological risks posed by NPs in the context of climate change. |
| title | Marine mussel metabolism under stress: Dual effects of nanoplastics and coastal hypoxia. |
| topic | Animals Mytilus Water Pollutants, Chemical Energy Metabolism Microplastics Oxygen Polystyrenes Stress, Physiological Hypoxia Oxidation-Reduction Citric Acid Cycle |
| url | https://pubmed.ncbi.nlm.nih.gov/39673953/ |