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| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Artículo científico |
| Language: | en |
| Published: |
International journal of molecular sciences
2024
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| Subjects: | |
| Online Access: | https://pubmed.ncbi.nlm.nih.gov/39684263/ |
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Table of Contents:
- Plasmalogens Improve Lymphatic Clearance of Amyloid Beta from Mouse Brain and Cognitive Functions. Shirokov, Alexander Zlatogosrkaya, Daria Adushkina, Viktoria Vodovozova, Elena Kardashevskaya, Kristina Sultanov, Ruslan Kasyanov, Sergey Blokhina, Inna Terskov, Andrey Tzoy, Maria Evsyukova, Arina Dubrovsky, Alexander Tuzhilkin, Matvey Elezarova, Inna Dmitrenko, Alexander Manzhaeva, Maria Krupnova, Valeria Semiachkina-Glushkovskaia, Anastasiia Ilyukov, Egor Myagkov, Dmitry Tuktarov, Dmitry Popov, Sergey Inozemzev, Tymophey Navolokin, Nikita Fedosov, Ivan Semyachkina-Glushkovskaya, Oxana Animals Amyloid beta-Peptides Mice Brain Plasmalogens Alzheimer Disease Cognition Male Disease Models, Animal Mice, Transgenic Mice, Inbred C57BL Cognitive Dysfunction Amyloid beta (Aβ) is a neuronal metabolic product that plays an important role in maintaining brain homeostasis. Normally, intensive brain Aβ formation is accompanied by its effective lymphatic removal. However, the excessive accumulation of brain Aβ is observed with age and during the development of Alzheimer's disease (AD) leading to cognitive impairment and memory deficits. There is emerging evidence that plasmalogens (Pls), as one of the key brain lipids, may be beneficial for AD and cognitive aging. Here, we studied the effects of Pls on cognitive functions and the lymphatic clearance of Aβ from the brain of AD mice and mice of different ages. The results showed that Pls effectively reduce brain Aβ levels and facilitate learning in aged but not old mice. In AD mice, Pls improve the lymphatic clearance of Aβ that is accompanied by an increase in general motor activity and an improvement of the emotional status and learning ability. Thus, these findings suggest that Pls could be a promising candidate for the alternative or concomitant therapy of AD and age-related brain diseases to enhance the lymphatic clearance of Aβ from the brain and cognitive functions.