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| Hauptverfasser: | , , , |
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| Format: | Artículo científico |
| Sprache: | en |
| Veröffentlicht: |
BMC genomics
2024
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| Schlagworte: | |
| Online-Zugang: | https://pubmed.ncbi.nlm.nih.gov/39701993/ |
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Inhaltsangabe:
- Cyclin-dependent kinases (CDKs) are key genes regulating early development of Neptunea arthritica cumingii: evidence from comparative transcriptome and proteome analyses. Lv, Fengxiao Ge, Xinfan Chang, Yaqing Hao, Zhenlin Animals Cyclin-Dependent Kinases Proteome Gene Expression Profiling Transcriptome Proteomics Gene Expression Regulation, Developmental Gastropoda Embryonic Development Multigene Family In this study, we applied comparative transcriptomics and proteomics techniques to systematically investigate the dynamic expression patterns of genes and proteins at various stages of early embryonic development of the gastropod Neptunea arthritica cumingii. Twelve cyclin-dependent kinase (CDKs) genes and five downstream proteins associated with these CDKs were identified. Through techniques such as qRT-PCR, our data elucidate for the first time the regulatory functions of CDK family genes and establish CDKs as a pivotal gene cluster in the early embryonic development of N. cumingii. These findings not only enhance the understanding of molecular developmental biology in N. cumingii and marine gastropods in general but also provide significant insights into the mechanisms involved in early embryonic development in N. cumingii. Furthermore, our results provide theoretical guidance for advancing artificial breeding technology for N. cumingii.