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| Format: | Artículo científico |
| Language: | en |
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International journal of antimicrobial agents
2025
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| Online Access: | https://pubmed.ncbi.nlm.nih.gov/39710145/ |
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| _version_ | 1868266265797197825 |
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| author | Tavares, Rafael D S Tacão, Marta Henriques, Isabel |
| author_facet | Tavares, Rafael D S Tacão, Marta Henriques, Isabel Tavares, Rafael D S Tacão, Marta Henriques, Isabel |
| collection | PubMed - marine biology |
| contents | Integrons are key players in the spread of beta-lactamase-encoding genes. Tavares, Rafael D S Tacão, Marta Henriques, Isabel Integrons beta-Lactamases Humans Bacteria Anti-Bacterial Agents beta-Lactam Resistance Gene Transfer, Horizontal Integrons mediate the acquisition and expression of gene cassettes (GCs). The production of beta-lactamases (BLs) is the most relevant mechanism of beta-lactams resistance. To explore the role of integrons in BL genes dissemination, sequences and metadata were retrieved from the INTEGRALL database and a literature review performed. Integrons (mostly class 1) carrying ≥1 BL-encoding genes (n = 1981) were detected in 37 bacterial genera and encoded BLs from 18 families. A total of 159 BL-encoding gene cassettes (BLGCs) were identified, representing all Ambler classes, with bla-, bla- and bla-carrying integrons the most prevalent. bla, bla and most metallo-BLs were exclusively associated with integrons. BL genes from 13 families were identified as genes captured by ISCR1 in complex integrons (n = 234), namely bla, bla and bla. Frequently co-detected GCs encoded resistance to all major classes of antibiotics, namely aminoglycosides, phenicols and trimethoprim. Most BLGCs encoded resistance to carbapenems (n = 90) and Pseudomonas aeruginosa was the most frequent host. Most bla-carrying integrons were from clinical contexts and wastewater was the richest environmental compartment. The frequent association of BLs and integrons indicates a significant role in dissemination of beta-lactams resistance. Considering that integrons are (i) low-cost structures often associated with other mobile elements, and (ii) often carry multiple GCs (interchangeable according to environmental stimuli), the association of BL genes with integrons should always be considered a risk factor for the spread of beta-lactam resistance when performing surveillance and epidemiological studies. Further studies monitoring prevalence and diversity of integrons, particularly across non-clinical environments, will draw a more comprehensive picture of integron-associated dissemination of beta-lactams resistance. |
| format | Artículo científico |
| id | pubmed_39710145 |
| institution | PubMed |
| language | en |
| publishDate | 2025 |
| publisher | International journal of antimicrobial agents |
| record_format | pubmed |
| spellingShingle | Integrons are key players in the spread of beta-lactamase-encoding genes. Tavares, Rafael D S Tacão, Marta Henriques, Isabel Integrons beta-Lactamases Humans Bacteria Anti-Bacterial Agents beta-Lactam Resistance Gene Transfer, Horizontal Integrons are key players in the spread of beta-lactamase-encoding genes. Tavares, Rafael D S Tacão, Marta Henriques, Isabel Integrons beta-Lactamases Humans Bacteria Anti-Bacterial Agents beta-Lactam Resistance Gene Transfer, Horizontal Integrons mediate the acquisition and expression of gene cassettes (GCs). The production of beta-lactamases (BLs) is the most relevant mechanism of beta-lactams resistance. To explore the role of integrons in BL genes dissemination, sequences and metadata were retrieved from the INTEGRALL database and a literature review performed. Integrons (mostly class 1) carrying ≥1 BL-encoding genes (n = 1981) were detected in 37 bacterial genera and encoded BLs from 18 families. A total of 159 BL-encoding gene cassettes (BLGCs) were identified, representing all Ambler classes, with bla-, bla- and bla-carrying integrons the most prevalent. bla, bla and most metallo-BLs were exclusively associated with integrons. BL genes from 13 families were identified as genes captured by ISCR1 in complex integrons (n = 234), namely bla, bla and bla. Frequently co-detected GCs encoded resistance to all major classes of antibiotics, namely aminoglycosides, phenicols and trimethoprim. Most BLGCs encoded resistance to carbapenems (n = 90) and Pseudomonas aeruginosa was the most frequent host. Most bla-carrying integrons were from clinical contexts and wastewater was the richest environmental compartment. The frequent association of BLs and integrons indicates a significant role in dissemination of beta-lactams resistance. Considering that integrons are (i) low-cost structures often associated with other mobile elements, and (ii) often carry multiple GCs (interchangeable according to environmental stimuli), the association of BL genes with integrons should always be considered a risk factor for the spread of beta-lactam resistance when performing surveillance and epidemiological studies. Further studies monitoring prevalence and diversity of integrons, particularly across non-clinical environments, will draw a more comprehensive picture of integron-associated dissemination of beta-lactams resistance. |
| title | Integrons are key players in the spread of beta-lactamase-encoding genes. |
| topic | Integrons beta-Lactamases Humans Bacteria Anti-Bacterial Agents beta-Lactam Resistance Gene Transfer, Horizontal |
| url | https://pubmed.ncbi.nlm.nih.gov/39710145/ |