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| Main Authors: | , , , , , , , , , |
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| Format: | Artículo científico |
| Language: | en |
| Published: |
Chemical & pharmaceutical bulletin
2024
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| Subjects: | |
| Online Access: | https://pubmed.ncbi.nlm.nih.gov/39721701/ |
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Table of Contents:
- Structures of Polyacetoxybriaranes Extracted from the Sea Whip Octocoral Junceella fragilis. Do, Hai Nhat Huang, Chih-Yin Chien, Su-Ying Zheng, Li-Guo Chen, You-Ying Zeng, Yun-Ting Su, Jui-Hsin Wen, Zhi-Hong Chang, Yu-Chia Sung, Ping-Jyun Anthozoa Humans Animals Mesenchymal Stem Cells Molecular Structure Cell Proliferation Molecular Conformation Crystallography, X-Ray Diterpenes In the present study, an algae-containing octocoral, Junceella fragilis, was subjected to chemical screening. The analysis resulted in the extraction of six polyacetoxybriaranes: a new compound, identified as fragilide Z (1), alongside previously identified analogs, which included 12-epi-fragilide G (2), fragilide P (3), junceellolide D (4), junceellonoid A (5), and juncin ZI (6). The structures of compounds 2-6 were investigated through single-crystal X-ray diffraction analysis, whereas that of 1 was examined through two-dimensional nuclear magnetic resonance analysis. Compounds 1-6 proved active in enhancing the growth of MG-63 human mesenchymal stem cells.