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| Main Authors: | , , , , |
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| Format: | Artículo científico |
| Language: | en |
| Published: |
The International journal of developmental biology
2024
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| Subjects: | |
| Online Access: | https://pubmed.ncbi.nlm.nih.gov/39723527/ |
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| _version_ | 1868266263050977280 |
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| author | Faisal, Muhammad Mehreen, Afshan Hays, Deli Yaseen, Faiza Liang, Yujun |
| author_facet | Faisal, Muhammad Mehreen, Afshan Hays, Deli Yaseen, Faiza Liang, Yujun Faisal, Muhammad Mehreen, Afshan Hays, Deli Yaseen, Faiza Liang, Yujun |
| collection | PubMed - marine biology |
| contents | The Genetic Odyssey of Axolotl Regeneration: Insights and Innovations. Faisal, Muhammad Mehreen, Afshan Hays, Deli Yaseen, Faiza Liang, Yujun Animals Regeneration Ambystoma mexicanum Signal Transduction Epigenesis, Genetic DNA Methylation MicroRNAs The axolotl, a legendary creature with the potential to regenerate complex body parts, is positioned as a powerful model organism due to its extraordinary regenerative capabilities. Axolotl can undergo successful regeneration of multiple structures, providing us with the opportunity to understand the factors that exhibit altered activity between regenerative and non-regenerative animals. This comprehensive review will explore the mysteries of axolotl regeneration, from the initial cellular triggers to the intricate signaling cascades that guide this complex process. We will delve deeply into the multifaceted interplay of genes and factors, highlighting the key role of signaling pathways and the influence of epigenetic modifications (such as DNA methylation, histone modification, and miRNA regulation) during regeneration. Furthermore, we will discuss how axolotls defy the odds by showing remarkable resistance to cancer, offering insights into potential therapeutic strategies. However, that is not the end; we will also highlight how age might affect the regenerative power of this creature. We hope this review will help navigate the awe-inspiring realm of axolotl regeneration, advance our understanding of regenerative biology, and chart pathways for future investigations aimed at uncovering new therapeutic approaches. |
| format | Artículo científico |
| id | pubmed_39723527 |
| institution | PubMed |
| language | en |
| publishDate | 2024 |
| publisher | The International journal of developmental biology |
| record_format | pubmed |
| spellingShingle | The Genetic Odyssey of Axolotl Regeneration: Insights and Innovations. Faisal, Muhammad Mehreen, Afshan Hays, Deli Yaseen, Faiza Liang, Yujun Animals Regeneration Ambystoma mexicanum Signal Transduction Epigenesis, Genetic DNA Methylation MicroRNAs The Genetic Odyssey of Axolotl Regeneration: Insights and Innovations. Faisal, Muhammad Mehreen, Afshan Hays, Deli Yaseen, Faiza Liang, Yujun Animals Regeneration Ambystoma mexicanum Signal Transduction Epigenesis, Genetic DNA Methylation MicroRNAs The axolotl, a legendary creature with the potential to regenerate complex body parts, is positioned as a powerful model organism due to its extraordinary regenerative capabilities. Axolotl can undergo successful regeneration of multiple structures, providing us with the opportunity to understand the factors that exhibit altered activity between regenerative and non-regenerative animals. This comprehensive review will explore the mysteries of axolotl regeneration, from the initial cellular triggers to the intricate signaling cascades that guide this complex process. We will delve deeply into the multifaceted interplay of genes and factors, highlighting the key role of signaling pathways and the influence of epigenetic modifications (such as DNA methylation, histone modification, and miRNA regulation) during regeneration. Furthermore, we will discuss how axolotls defy the odds by showing remarkable resistance to cancer, offering insights into potential therapeutic strategies. However, that is not the end; we will also highlight how age might affect the regenerative power of this creature. We hope this review will help navigate the awe-inspiring realm of axolotl regeneration, advance our understanding of regenerative biology, and chart pathways for future investigations aimed at uncovering new therapeutic approaches. |
| title | The Genetic Odyssey of Axolotl Regeneration: Insights and Innovations. |
| topic | Animals Regeneration Ambystoma mexicanum Signal Transduction Epigenesis, Genetic DNA Methylation MicroRNAs |
| url | https://pubmed.ncbi.nlm.nih.gov/39723527/ |