Eremophilane- and Acorane-Type Sesquiterpenes from the Deep-Sea Cold-Seep-Derived Fungus CS-280 Cultured in the Presence of Autoclaved QDIO-4.
Fuente:
PubMed
Guardado en:
| Autores principales: | , , , , |
|---|---|
| Formato: | Artículo científico |
| Lenguaje: | en |
| Publicado: |
Marine drugs
2024
|
| Materias: | |
| Acceso en línea: | |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| _version_ | 1868266263039442944 |
|---|---|
| author | Chen, Xiao-Dan Li, Xin Li, Xiao-Ming Yang, Sui-Qun Wang, Bin-Gui |
| author_facet | Chen, Xiao-Dan Li, Xin Li, Xiao-Ming Yang, Sui-Qun Wang, Bin-Gui Chen, Xiao-Dan Li, Xin Li, Xiao-Ming Yang, Sui-Qun Wang, Bin-Gui |
| collection | PubMed - marine biology |
| contents | Eremophilane- and Acorane-Type Sesquiterpenes from the Deep-Sea Cold-Seep-Derived Fungus CS-280 Cultured in the Presence of Autoclaved QDIO-4. Chen, Xiao-Dan Li, Xin Li, Xiao-Ming Yang, Sui-Qun Wang, Bin-Gui Pseudomonas aeruginosa Sesquiterpenes Humans Anti-Inflammatory Agents Crystallography, X-Ray Polycyclic Sesquiterpenes Cyclooxygenase 2 Molecular Docking Simulation Cyclooxygenase 2 Inhibitors Six new sesquiterpenes, including four eremophilane derivatives fureremophilanes A-D (-) and two acorane analogues furacoranes A and B ( and ), were characterized from the culture extract of the cold-seep derived fungus CS-280 co-cultured with autoclaved QDIO-4. All the six compounds were highly oxygenated especially and with infrequent epoxyethane and tetrahydrofuran ring systems. The structures of - were established on the basis of detailed interpretation of 1D and 2D NMR and MS data. Their relative and absolute configurations were assigned by a combination of NOESY and single crystal X-ray crystallographic analysis, and by time-dependent density functional (TDDFT) ECD calculations as well. All compounds were tested the anti-inflammatory activity against human COX-2 protein, among which, compounds and displayed activities with IC values 123.00 µM and 93.45 µM, respectively. The interaction mechanism was interpreted by molecular docking. |
| format | Artículo científico |
| id | pubmed_39728148 |
| institution | PubMed |
| language | en |
| publishDate | 2024 |
| publisher | Marine drugs |
| record_format | pubmed |
| spellingShingle | Eremophilane- and Acorane-Type Sesquiterpenes from the Deep-Sea Cold-Seep-Derived Fungus CS-280 Cultured in the Presence of Autoclaved QDIO-4. Chen, Xiao-Dan Li, Xin Li, Xiao-Ming Yang, Sui-Qun Wang, Bin-Gui Pseudomonas aeruginosa Sesquiterpenes Humans Anti-Inflammatory Agents Crystallography, X-Ray Polycyclic Sesquiterpenes Cyclooxygenase 2 Molecular Docking Simulation Cyclooxygenase 2 Inhibitors Eremophilane- and Acorane-Type Sesquiterpenes from the Deep-Sea Cold-Seep-Derived Fungus CS-280 Cultured in the Presence of Autoclaved QDIO-4. Chen, Xiao-Dan Li, Xin Li, Xiao-Ming Yang, Sui-Qun Wang, Bin-Gui Pseudomonas aeruginosa Sesquiterpenes Humans Anti-Inflammatory Agents Crystallography, X-Ray Polycyclic Sesquiterpenes Cyclooxygenase 2 Molecular Docking Simulation Cyclooxygenase 2 Inhibitors Six new sesquiterpenes, including four eremophilane derivatives fureremophilanes A-D (-) and two acorane analogues furacoranes A and B ( and ), were characterized from the culture extract of the cold-seep derived fungus CS-280 co-cultured with autoclaved QDIO-4. All the six compounds were highly oxygenated especially and with infrequent epoxyethane and tetrahydrofuran ring systems. The structures of - were established on the basis of detailed interpretation of 1D and 2D NMR and MS data. Their relative and absolute configurations were assigned by a combination of NOESY and single crystal X-ray crystallographic analysis, and by time-dependent density functional (TDDFT) ECD calculations as well. All compounds were tested the anti-inflammatory activity against human COX-2 protein, among which, compounds and displayed activities with IC values 123.00 µM and 93.45 µM, respectively. The interaction mechanism was interpreted by molecular docking. |
| title | Eremophilane- and Acorane-Type Sesquiterpenes from the Deep-Sea Cold-Seep-Derived Fungus CS-280 Cultured in the Presence of Autoclaved QDIO-4. |
| topic | Pseudomonas aeruginosa Sesquiterpenes Humans Anti-Inflammatory Agents Crystallography, X-Ray Polycyclic Sesquiterpenes Cyclooxygenase 2 Molecular Docking Simulation Cyclooxygenase 2 Inhibitors |
| url | https://pubmed.ncbi.nlm.nih.gov/39728148/ |