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| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Artículo científico |
| Language: | en |
| Published: |
Nature communications
2024
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| Subjects: | |
| Online Access: | https://pubmed.ncbi.nlm.nih.gov/39738107/ |
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| _version_ | 1868266263021617153 |
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| author | Li, Tong Wang, Xiaoyu Wang, Yuting Zhang, Yihong Li, Sirong Liu, Wanling Liu, Shujie Liu, Yufeng Xing, Hang Otake, Ken-Ichi Kitagawa, Susumu Wu, Jiangjiexing Dong, Hao Wei, Hui |
| author_facet | Li, Tong Wang, Xiaoyu Wang, Yuting Zhang, Yihong Li, Sirong Liu, Wanling Liu, Shujie Liu, Yufeng Xing, Hang Otake, Ken-Ichi Kitagawa, Susumu Wu, Jiangjiexing Dong, Hao Wei, Hui Li, Tong Wang, Xiaoyu Wang, Yuting Zhang, Yihong Li, Sirong Liu, Wanling Liu, Shujie Liu, Yufeng Xing, Hang Otake, Ken-Ichi Kitagawa, Susumu Wu, Jiangjiexing Dong, Hao Wei, Hui |
| collection | PubMed - marine biology |
| contents | Microenvironmental modulation breaks intrinsic pH limitations of nanozymes to boost their activities. Li, Tong Wang, Xiaoyu Wang, Yuting Zhang, Yihong Li, Sirong Liu, Wanling Liu, Shujie Liu, Yufeng Xing, Hang Otake, Ken-Ichi Kitagawa, Susumu Wu, Jiangjiexing Dong, Hao Wei, Hui Hydrogen-Ion Concentration Nanostructures Metal-Organic Frameworks Molecular Dynamics Simulation Acrylic Resins Catalysis Peroxidase Functional nanomaterials with enzyme-mimicking activities, termed as nanozymes, have found wide applications in various fields. However, the deviation between the working and optimal pHs of nanozymes has been limiting their practical applications. Here we develop a strategy to modulate the microenvironmental pHs of metal-organic framework (MOF) nanozymes by confining polyacids or polybases (serving as Brønsted acids or bases). The confinement of poly(acrylic acid) (PAA) into the channels of peroxidase-mimicking PCN-222-Fe (PCN = porous coordination network) nanozyme lowers its microenvironmental pH, enabling it to perform its best activity at pH 7.4 and to solve pH mismatch in cascade systems coupled with acid-denatured oxidases. Experimental investigations and molecular dynamics simulations reveal that PAA not only donates protons but also holds protons through the salt bridges between hydroniums and deprotonated carboxyl groups in neutral pH condition. Therefore, the confinement of poly(ethylene imine) increases the microenvironmental pH, leading to the enhanced hydrolase-mimicking activity of MOF nanozymes. This strategy is expected to pave a promising way for designing high-performance nanozymes and nanocatalysts for practical applications. |
| format | Artículo científico |
| id | pubmed_39738107 |
| institution | PubMed |
| language | en |
| publishDate | 2024 |
| publisher | Nature communications |
| record_format | pubmed |
| spellingShingle | Microenvironmental modulation breaks intrinsic pH limitations of nanozymes to boost their activities. Li, Tong Wang, Xiaoyu Wang, Yuting Zhang, Yihong Li, Sirong Liu, Wanling Liu, Shujie Liu, Yufeng Xing, Hang Otake, Ken-Ichi Kitagawa, Susumu Wu, Jiangjiexing Dong, Hao Wei, Hui Hydrogen-Ion Concentration Nanostructures Metal-Organic Frameworks Molecular Dynamics Simulation Acrylic Resins Catalysis Peroxidase Microenvironmental modulation breaks intrinsic pH limitations of nanozymes to boost their activities. Li, Tong Wang, Xiaoyu Wang, Yuting Zhang, Yihong Li, Sirong Liu, Wanling Liu, Shujie Liu, Yufeng Xing, Hang Otake, Ken-Ichi Kitagawa, Susumu Wu, Jiangjiexing Dong, Hao Wei, Hui Hydrogen-Ion Concentration Nanostructures Metal-Organic Frameworks Molecular Dynamics Simulation Acrylic Resins Catalysis Peroxidase Functional nanomaterials with enzyme-mimicking activities, termed as nanozymes, have found wide applications in various fields. However, the deviation between the working and optimal pHs of nanozymes has been limiting their practical applications. Here we develop a strategy to modulate the microenvironmental pHs of metal-organic framework (MOF) nanozymes by confining polyacids or polybases (serving as Brønsted acids or bases). The confinement of poly(acrylic acid) (PAA) into the channels of peroxidase-mimicking PCN-222-Fe (PCN = porous coordination network) nanozyme lowers its microenvironmental pH, enabling it to perform its best activity at pH 7.4 and to solve pH mismatch in cascade systems coupled with acid-denatured oxidases. Experimental investigations and molecular dynamics simulations reveal that PAA not only donates protons but also holds protons through the salt bridges between hydroniums and deprotonated carboxyl groups in neutral pH condition. Therefore, the confinement of poly(ethylene imine) increases the microenvironmental pH, leading to the enhanced hydrolase-mimicking activity of MOF nanozymes. This strategy is expected to pave a promising way for designing high-performance nanozymes and nanocatalysts for practical applications. |
| title | Microenvironmental modulation breaks intrinsic pH limitations of nanozymes to boost their activities. |
| topic | Hydrogen-Ion Concentration Nanostructures Metal-Organic Frameworks Molecular Dynamics Simulation Acrylic Resins Catalysis Peroxidase |
| url | https://pubmed.ncbi.nlm.nih.gov/39738107/ |