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| Main Authors: | , , , , , , , , , , |
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| Format: | Artículo científico |
| Language: | en |
| Published: |
Cell
2025
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| Subjects: | |
| Online Access: | https://pubmed.ncbi.nlm.nih.gov/39742807/ |
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| _version_ | 1868266260638203905 |
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| author | Almoril-Porras, Agustin Calvo, Ana C Niu, Longgang Beagan, Jonathan Díaz García, Malcom Hawk, Josh D Aljobeh, Ahmad Wisdom, Elias M Ren, Ivy Wang, Zhao-Wen Colón-Ramos, Daniel A |
| author_facet | Almoril-Porras, Agustin Calvo, Ana C Niu, Longgang Beagan, Jonathan Díaz García, Malcom Hawk, Josh D Aljobeh, Ahmad Wisdom, Elias M Ren, Ivy Wang, Zhao-Wen Colón-Ramos, Daniel A Almoril-Porras, Agustin Calvo, Ana C Niu, Longgang Beagan, Jonathan Díaz García, Malcom Hawk, Josh D Aljobeh, Ahmad Wisdom, Elias M Ren, Ivy Wang, Zhao-Wen Colón-Ramos, Daniel A |
| collection | PubMed - marine biology |
| contents | Configuration of electrical synapses filters sensory information to drive behavioral choices. Almoril-Porras, Agustin Calvo, Ana C Niu, Longgang Beagan, Jonathan Díaz García, Malcom Hawk, Josh D Aljobeh, Ahmad Wisdom, Elias M Ren, Ivy Wang, Zhao-Wen Colón-Ramos, Daniel A Animals Caenorhabditis elegans Electrical Synapses Caenorhabditis elegans Proteins Interneurons Connexins Behavior, Animal Taxis Response Gap Junctions Mutation Synaptic configurations underpin how the nervous system processes sensory information to produce a behavioral response. This is best understood for chemical synapses, and we know far less about how electrical synaptic configurations modulate sensory information processing and context-specific behaviors. We discovered that innexin 1 (INX-1), a gap junction protein that forms electrical synapses, is required to deploy context-specific behavioral strategies underlying thermotaxis behavior in C. elegans. Within this well-defined circuit, INX-1 couples two bilaterally symmetric interneurons to integrate sensory information during migratory behavior across temperature gradients. In inx-1 mutants, uncoupled interneurons display increased excitability and responses to subthreshold sensory stimuli due to increased membrane resistance and reduced membrane capacitance, resulting in abnormal responses that extend run durations and trap the animals in context-irrelevant tracking of isotherms. Thus, a conserved configuration of electrical synapses enables differential processing of sensory information to deploy context-specific behavioral strategies. |
| format | Artículo científico |
| id | pubmed_39742807 |
| institution | PubMed |
| language | en |
| publishDate | 2025 |
| publisher | Cell |
| record_format | pubmed |
| spellingShingle | Configuration of electrical synapses filters sensory information to drive behavioral choices. Almoril-Porras, Agustin Calvo, Ana C Niu, Longgang Beagan, Jonathan Díaz García, Malcom Hawk, Josh D Aljobeh, Ahmad Wisdom, Elias M Ren, Ivy Wang, Zhao-Wen Colón-Ramos, Daniel A Animals Caenorhabditis elegans Electrical Synapses Caenorhabditis elegans Proteins Interneurons Connexins Behavior, Animal Taxis Response Gap Junctions Mutation Configuration of electrical synapses filters sensory information to drive behavioral choices. Almoril-Porras, Agustin Calvo, Ana C Niu, Longgang Beagan, Jonathan Díaz García, Malcom Hawk, Josh D Aljobeh, Ahmad Wisdom, Elias M Ren, Ivy Wang, Zhao-Wen Colón-Ramos, Daniel A Animals Caenorhabditis elegans Electrical Synapses Caenorhabditis elegans Proteins Interneurons Connexins Behavior, Animal Taxis Response Gap Junctions Mutation Synaptic configurations underpin how the nervous system processes sensory information to produce a behavioral response. This is best understood for chemical synapses, and we know far less about how electrical synaptic configurations modulate sensory information processing and context-specific behaviors. We discovered that innexin 1 (INX-1), a gap junction protein that forms electrical synapses, is required to deploy context-specific behavioral strategies underlying thermotaxis behavior in C. elegans. Within this well-defined circuit, INX-1 couples two bilaterally symmetric interneurons to integrate sensory information during migratory behavior across temperature gradients. In inx-1 mutants, uncoupled interneurons display increased excitability and responses to subthreshold sensory stimuli due to increased membrane resistance and reduced membrane capacitance, resulting in abnormal responses that extend run durations and trap the animals in context-irrelevant tracking of isotherms. Thus, a conserved configuration of electrical synapses enables differential processing of sensory information to deploy context-specific behavioral strategies. |
| title | Configuration of electrical synapses filters sensory information to drive behavioral choices. |
| topic | Animals Caenorhabditis elegans Electrical Synapses Caenorhabditis elegans Proteins Interneurons Connexins Behavior, Animal Taxis Response Gap Junctions Mutation |
| url | https://pubmed.ncbi.nlm.nih.gov/39742807/ |