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| Main Authors: | , , , , |
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| Format: | Artículo científico |
| Language: | en |
| Published: |
Journal of agricultural and food chemistry
2025
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| Subjects: | |
| Online Access: | https://pubmed.ncbi.nlm.nih.gov/39745281/ |
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| _version_ | 1868266260634009602 |
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| author | Dong, Yu-Liang Li, Xiao-Ming Wang, Yi-Ran Meng, Ling-Hong Wang, Bin-Gui |
| author_facet | Dong, Yu-Liang Li, Xiao-Ming Wang, Yi-Ran Meng, Ling-Hong Wang, Bin-Gui Dong, Yu-Liang Li, Xiao-Ming Wang, Yi-Ran Meng, Ling-Hong Wang, Bin-Gui |
| collection | PubMed - marine biology |
| contents | Antibacterial and Cytotoxic Methylthioether-Containing Cytochalasins from AS-506, an Endozoic Fungus Associated with Deep-Sea Sponge of Magellan Seamounts. Dong, Yu-Liang Li, Xiao-Ming Wang, Yi-Ran Meng, Ling-Hong Wang, Bin-Gui Chaetomium Anti-Bacterial Agents Porifera Cytochalasins Animals Humans Molecular Structure Antineoplastic Agents Cell Line, Tumor Pacific Ocean Ten cytochalasin derivatives, including six new methylthioether-containing chaetoglobosins (thiochaetoglobosins A-F, ), a new related congener (18-nor-prochaetoglobosin II, ), and three known unsulfured counterparts (), were isolated and identified from AS-506, an endozoic fungus isolated from a deep-sea sponge, which was collected from Magellan Seamounts in the Western Pacific Ocean. Their structures were determined by extensive interpretation of the spectroscopic and X-ray crystallographic data, as well as by ECD calculations. Structurally, thiochaetoglobosins A-F () represent the first examples of chaetoglobosin derivatives containing a methylthioether group in the molecules, while 18-nor-prochaetoglobosin II () is the first 18-nor-chaetoglobosin derivative. Precursor incubation experiments with [C-CH]-l-methionine confirmed that the thio-linked methyl was derived from methionine, and a new isotope-labeled thiochaetoglobosin () was also isolated and identified. Compound exhibited activity against the aquatic pathogenic bacterium (MIC = 0.5 μg/mL), comparable to that of the positive control chloramphenicol. The cell morphology of was studied by using growth curves and scanning electron microscopy (SEM) data. The results showed that compound could affect the integrity of the membrane to induce bacteriolysis and death of . Additionally, compounds , , , , and showed cytotoxic activities against several tumor cell lines with IC values ranging from 0.72 to 17.66 μM. |
| format | Artículo científico |
| id | pubmed_39745281 |
| institution | PubMed |
| language | en |
| publishDate | 2025 |
| publisher | Journal of agricultural and food chemistry |
| record_format | pubmed |
| spellingShingle | Antibacterial and Cytotoxic Methylthioether-Containing Cytochalasins from AS-506, an Endozoic Fungus Associated with Deep-Sea Sponge of Magellan Seamounts. Dong, Yu-Liang Li, Xiao-Ming Wang, Yi-Ran Meng, Ling-Hong Wang, Bin-Gui Chaetomium Anti-Bacterial Agents Porifera Cytochalasins Animals Humans Molecular Structure Antineoplastic Agents Cell Line, Tumor Pacific Ocean Antibacterial and Cytotoxic Methylthioether-Containing Cytochalasins from AS-506, an Endozoic Fungus Associated with Deep-Sea Sponge of Magellan Seamounts. Dong, Yu-Liang Li, Xiao-Ming Wang, Yi-Ran Meng, Ling-Hong Wang, Bin-Gui Chaetomium Anti-Bacterial Agents Porifera Cytochalasins Animals Humans Molecular Structure Antineoplastic Agents Cell Line, Tumor Pacific Ocean Ten cytochalasin derivatives, including six new methylthioether-containing chaetoglobosins (thiochaetoglobosins A-F, ), a new related congener (18-nor-prochaetoglobosin II, ), and three known unsulfured counterparts (), were isolated and identified from AS-506, an endozoic fungus isolated from a deep-sea sponge, which was collected from Magellan Seamounts in the Western Pacific Ocean. Their structures were determined by extensive interpretation of the spectroscopic and X-ray crystallographic data, as well as by ECD calculations. Structurally, thiochaetoglobosins A-F () represent the first examples of chaetoglobosin derivatives containing a methylthioether group in the molecules, while 18-nor-prochaetoglobosin II () is the first 18-nor-chaetoglobosin derivative. Precursor incubation experiments with [C-CH]-l-methionine confirmed that the thio-linked methyl was derived from methionine, and a new isotope-labeled thiochaetoglobosin () was also isolated and identified. Compound exhibited activity against the aquatic pathogenic bacterium (MIC = 0.5 μg/mL), comparable to that of the positive control chloramphenicol. The cell morphology of was studied by using growth curves and scanning electron microscopy (SEM) data. The results showed that compound could affect the integrity of the membrane to induce bacteriolysis and death of . Additionally, compounds , , , , and showed cytotoxic activities against several tumor cell lines with IC values ranging from 0.72 to 17.66 μM. |
| title | Antibacterial and Cytotoxic Methylthioether-Containing Cytochalasins from AS-506, an Endozoic Fungus Associated with Deep-Sea Sponge of Magellan Seamounts. |
| topic | Chaetomium Anti-Bacterial Agents Porifera Cytochalasins Animals Humans Molecular Structure Antineoplastic Agents Cell Line, Tumor Pacific Ocean |
| url | https://pubmed.ncbi.nlm.nih.gov/39745281/ |