Laboratory-simulated marine heatwave enhances physiological damage to mussels exposed to titanium dioxide nanoparticles by disrupting the gut-hepatopancreas axis.
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| Format: | Artículo científico |
| Langue: | en |
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Journal of hazardous materials
2025
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| _version_ | 1868266260626669569 |
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| author | Wei, Shuaishuai Hu, Menghong Sokolova, Inna Tu, Zhihan Chen, Liming Xu, Peng Mao, Yiran Wang, Shixiu Wang, Youji |
| author_facet | Wei, Shuaishuai Hu, Menghong Sokolova, Inna Tu, Zhihan Chen, Liming Xu, Peng Mao, Yiran Wang, Shixiu Wang, Youji Wei, Shuaishuai Hu, Menghong Sokolova, Inna Tu, Zhihan Chen, Liming Xu, Peng Mao, Yiran Wang, Shixiu Wang, Youji |
| collection | PubMed - marine biology |
| contents | Laboratory-simulated marine heatwave enhances physiological damage to mussels exposed to titanium dioxide nanoparticles by disrupting the gut-hepatopancreas axis. Wei, Shuaishuai Hu, Menghong Sokolova, Inna Tu, Zhihan Chen, Liming Xu, Peng Mao, Yiran Wang, Shixiu Wang, Youji Animals Titanium Hepatopancreas Water Pollutants, Chemical Mytilus Hot Temperature Nanoparticles Metal Nanoparticles NF-kappa B The aggregation state of nano-TiO in the environment is altered under marine heatwaves (MHWs), thus affecting its bioavailability and toxicity to the marine organisms. Here, we investigated the toxic mechanisms and effects of nano-TiO on gut-hepatopancreas axis health of Mytilus coruscus exposed to 25 and 250 μg/L of nano-TiO under laboratory-simulated MHW. Compared with the control conditions or post-MHW cooling phase, prolonged MHW exposure significantly inhibited digestive function, decreased immune-related enzymes activities, and caused neurotoxicity in the mussels. 16S rRNA analysis demonstrated that high concentration nano-TiO and combined exposures decreased the abundance of Bacteroidota while increased the Proteobacteria. Additionally, the elevated pro-inflammatory bacteria released endotoxin lipopolysaccharide (LPS), which activated Toll-like receptor 4 (TLR-4) in the hepatopancreas and induced hepatopancreatic inflammation by downregulating nuclear factor-kappa B (NF-κB) signaling pathway and detoxification-related genes. Furthermore, nano-TiO and MHW exposure dysregulated the glutathione system, decreased the levels of antioxidation-related genes, and induced the accumulation of ROS and lipid peroxide (LPO) contents, thus causing severe oxidative damage and hepatopancreatic cell apoptosis. These findings demonstrate that nano-TiO and MHW induce hepatopancreatic inflammation and cell damage, which are strongly associated with the gut lesions and disrupted gut-hepatopancreas axis homeostasis. |
| format | Artículo científico |
| id | pubmed_39752825 |
| institution | PubMed |
| language | en |
| publishDate | 2025 |
| publisher | Journal of hazardous materials |
| record_format | pubmed |
| spellingShingle | Laboratory-simulated marine heatwave enhances physiological damage to mussels exposed to titanium dioxide nanoparticles by disrupting the gut-hepatopancreas axis. Wei, Shuaishuai Hu, Menghong Sokolova, Inna Tu, Zhihan Chen, Liming Xu, Peng Mao, Yiran Wang, Shixiu Wang, Youji Animals Titanium Hepatopancreas Water Pollutants, Chemical Mytilus Hot Temperature Nanoparticles Metal Nanoparticles NF-kappa B Laboratory-simulated marine heatwave enhances physiological damage to mussels exposed to titanium dioxide nanoparticles by disrupting the gut-hepatopancreas axis. Wei, Shuaishuai Hu, Menghong Sokolova, Inna Tu, Zhihan Chen, Liming Xu, Peng Mao, Yiran Wang, Shixiu Wang, Youji Animals Titanium Hepatopancreas Water Pollutants, Chemical Mytilus Hot Temperature Nanoparticles Metal Nanoparticles NF-kappa B The aggregation state of nano-TiO in the environment is altered under marine heatwaves (MHWs), thus affecting its bioavailability and toxicity to the marine organisms. Here, we investigated the toxic mechanisms and effects of nano-TiO on gut-hepatopancreas axis health of Mytilus coruscus exposed to 25 and 250 μg/L of nano-TiO under laboratory-simulated MHW. Compared with the control conditions or post-MHW cooling phase, prolonged MHW exposure significantly inhibited digestive function, decreased immune-related enzymes activities, and caused neurotoxicity in the mussels. 16S rRNA analysis demonstrated that high concentration nano-TiO and combined exposures decreased the abundance of Bacteroidota while increased the Proteobacteria. Additionally, the elevated pro-inflammatory bacteria released endotoxin lipopolysaccharide (LPS), which activated Toll-like receptor 4 (TLR-4) in the hepatopancreas and induced hepatopancreatic inflammation by downregulating nuclear factor-kappa B (NF-κB) signaling pathway and detoxification-related genes. Furthermore, nano-TiO and MHW exposure dysregulated the glutathione system, decreased the levels of antioxidation-related genes, and induced the accumulation of ROS and lipid peroxide (LPO) contents, thus causing severe oxidative damage and hepatopancreatic cell apoptosis. These findings demonstrate that nano-TiO and MHW induce hepatopancreatic inflammation and cell damage, which are strongly associated with the gut lesions and disrupted gut-hepatopancreas axis homeostasis. |
| title | Laboratory-simulated marine heatwave enhances physiological damage to mussels exposed to titanium dioxide nanoparticles by disrupting the gut-hepatopancreas axis. |
| topic | Animals Titanium Hepatopancreas Water Pollutants, Chemical Mytilus Hot Temperature Nanoparticles Metal Nanoparticles NF-kappa B |
| url | https://pubmed.ncbi.nlm.nih.gov/39752825/ |