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| Auteurs principaux: | , , , , , , , , |
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| Format: | Artículo científico |
| Langue: | en |
| Publié: |
Phytochemistry
2025
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| Sujets: | |
| Accès en ligne: | https://pubmed.ncbi.nlm.nih.gov/39755325/ |
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| _version_ | 1868266260618280961 |
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| author | Shi, Xiao-Shan Yang, Sui-Qun Li, Xiao-Ming Li, Yan-He Wang, Dun-Jia Li, Xin Meng, Ling-Hong Zhou, Xing-Wang Wang, Bin-Gui |
| author_facet | Shi, Xiao-Shan Yang, Sui-Qun Li, Xiao-Ming Li, Yan-He Wang, Dun-Jia Li, Xin Meng, Ling-Hong Zhou, Xing-Wang Wang, Bin-Gui Shi, Xiao-Shan Yang, Sui-Qun Li, Xiao-Ming Li, Yan-He Wang, Dun-Jia Li, Xin Meng, Ling-Hong Zhou, Xing-Wang Wang, Bin-Gui |
| collection | PubMed - marine biology |
| contents | Antimicrobial polyketides from the endophytic fungus Fusarium asiaticum QA-6 derived from medicinal plant Artemisia argyi. Shi, Xiao-Shan Yang, Sui-Qun Li, Xiao-Ming Li, Yan-He Wang, Dun-Jia Li, Xin Meng, Ling-Hong Zhou, Xing-Wang Wang, Bin-Gui Fusarium Microbial Sensitivity Tests Artemisia Anti-Bacterial Agents Polyketides Plants, Medicinal Molecular Structure Pseudomonas aeruginosa Vibrio Crystallography, X-Ray Structure-Activity Relationship Seven previously undescribed polyketide derivatives, fusariumtides A-G (1-7), together with three known analogues (8-10), were isolated from the culture extract of Fusarium asiaticum QA-6, an endophytic fungus obtained from the fresh stem tissue of the medicinal plant Artemisia argyi H. Lev. & Vaniot. Their structures were elucidated by detailed interpretation of 1D/2D NMR spectroscopic and mass spectrometric data, and the absolute configuration of compound 1 was established on the basis of X-ray crystallographic analysis and ECD and specific rotation (SR) calculations. The isolated compounds, which possessed a functionalized decalin moiety, were evaluated for antimicrobial activities. Compounds 1 and 10 exhibited broad-spectrum inhibitory activities against nine tested pathogenic bacteria with MIC values ranging from 1 to 64 μg/mL, while compound 8 showed potent inhibitory activities against aquatic pathogens Aeromonas hydrophilia, Pseudomonas aeruginosa, Vibrio harveyi, and V. vulnificus, which were comparable to/or stronger than those of the positive control chloramphenicol. |
| format | Artículo científico |
| id | pubmed_39755325 |
| institution | PubMed |
| language | en |
| publishDate | 2025 |
| publisher | Phytochemistry |
| record_format | pubmed |
| spellingShingle | Antimicrobial polyketides from the endophytic fungus Fusarium asiaticum QA-6 derived from medicinal plant Artemisia argyi. Shi, Xiao-Shan Yang, Sui-Qun Li, Xiao-Ming Li, Yan-He Wang, Dun-Jia Li, Xin Meng, Ling-Hong Zhou, Xing-Wang Wang, Bin-Gui Fusarium Microbial Sensitivity Tests Artemisia Anti-Bacterial Agents Polyketides Plants, Medicinal Molecular Structure Pseudomonas aeruginosa Vibrio Crystallography, X-Ray Structure-Activity Relationship Antimicrobial polyketides from the endophytic fungus Fusarium asiaticum QA-6 derived from medicinal plant Artemisia argyi. Shi, Xiao-Shan Yang, Sui-Qun Li, Xiao-Ming Li, Yan-He Wang, Dun-Jia Li, Xin Meng, Ling-Hong Zhou, Xing-Wang Wang, Bin-Gui Fusarium Microbial Sensitivity Tests Artemisia Anti-Bacterial Agents Polyketides Plants, Medicinal Molecular Structure Pseudomonas aeruginosa Vibrio Crystallography, X-Ray Structure-Activity Relationship Seven previously undescribed polyketide derivatives, fusariumtides A-G (1-7), together with three known analogues (8-10), were isolated from the culture extract of Fusarium asiaticum QA-6, an endophytic fungus obtained from the fresh stem tissue of the medicinal plant Artemisia argyi H. Lev. & Vaniot. Their structures were elucidated by detailed interpretation of 1D/2D NMR spectroscopic and mass spectrometric data, and the absolute configuration of compound 1 was established on the basis of X-ray crystallographic analysis and ECD and specific rotation (SR) calculations. The isolated compounds, which possessed a functionalized decalin moiety, were evaluated for antimicrobial activities. Compounds 1 and 10 exhibited broad-spectrum inhibitory activities against nine tested pathogenic bacteria with MIC values ranging from 1 to 64 μg/mL, while compound 8 showed potent inhibitory activities against aquatic pathogens Aeromonas hydrophilia, Pseudomonas aeruginosa, Vibrio harveyi, and V. vulnificus, which were comparable to/or stronger than those of the positive control chloramphenicol. |
| title | Antimicrobial polyketides from the endophytic fungus Fusarium asiaticum QA-6 derived from medicinal plant Artemisia argyi. |
| topic | Fusarium Microbial Sensitivity Tests Artemisia Anti-Bacterial Agents Polyketides Plants, Medicinal Molecular Structure Pseudomonas aeruginosa Vibrio Crystallography, X-Ray Structure-Activity Relationship |
| url | https://pubmed.ncbi.nlm.nih.gov/39755325/ |