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| Main Authors: | , , , , , , |
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| Format: | Artículo científico |
| Language: | en |
| Published: |
Phytochemistry
2025
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| Subjects: | |
| Online Access: | https://pubmed.ncbi.nlm.nih.gov/39755326/ |
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| _version_ | 1868266260618280960 |
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| author | Liu, Yi-Wei Hu, Xue-Yi Chen, Xiao-Dan Li, Xiao-Ming Yang, Sui-Qun Li, Hong-Lei Wang, Bin-Gui |
| author_facet | Liu, Yi-Wei Hu, Xue-Yi Chen, Xiao-Dan Li, Xiao-Ming Yang, Sui-Qun Li, Hong-Lei Wang, Bin-Gui Liu, Yi-Wei Hu, Xue-Yi Chen, Xiao-Dan Li, Xiao-Ming Yang, Sui-Qun Li, Hong-Lei Wang, Bin-Gui |
| collection | PubMed - marine biology |
| contents | Chermesins I-N: Bioactive spiromeroterpenoids from the marine-sourced fungus Penicillium chermesinum AS-400. Liu, Yi-Wei Hu, Xue-Yi Chen, Xiao-Dan Li, Xiao-Ming Yang, Sui-Qun Li, Hong-Lei Wang, Bin-Gui Penicillium Microbial Sensitivity Tests Molecular Structure Anti-Bacterial Agents Crystallography, X-Ray Humans Molecular Conformation Six previously undescribed spiromeroterpenoids, chermesins I-N (1-6), were isolated and identified from the marine-sourced fungus Penicillium chermesinum AS-400. Their structures were determined by nuclear magnetic resonance and mass spectroscopic data, and the relative and absolute configurations were confirmed based on nuclear Overhauser effect spectroscopic experiments, electronic circular dichroism (ECD) calculations and X-ray crystallographic analysis, and by comparisons of ECD Cotton effects with those of known congeners as well. Structurally, compound 1 represents the first example of spiromeroterpenoid demethylated at C-4. The isolated compounds exhibited inhibitory activities against several aquatic and human pathogenic bacteria with MIC values ranging from 4 to 64 μg/mL. |
| format | Artículo científico |
| id | pubmed_39755326 |
| institution | PubMed |
| language | en |
| publishDate | 2025 |
| publisher | Phytochemistry |
| record_format | pubmed |
| spellingShingle | Chermesins I-N: Bioactive spiromeroterpenoids from the marine-sourced fungus Penicillium chermesinum AS-400. Liu, Yi-Wei Hu, Xue-Yi Chen, Xiao-Dan Li, Xiao-Ming Yang, Sui-Qun Li, Hong-Lei Wang, Bin-Gui Penicillium Microbial Sensitivity Tests Molecular Structure Anti-Bacterial Agents Crystallography, X-Ray Humans Molecular Conformation Chermesins I-N: Bioactive spiromeroterpenoids from the marine-sourced fungus Penicillium chermesinum AS-400. Liu, Yi-Wei Hu, Xue-Yi Chen, Xiao-Dan Li, Xiao-Ming Yang, Sui-Qun Li, Hong-Lei Wang, Bin-Gui Penicillium Microbial Sensitivity Tests Molecular Structure Anti-Bacterial Agents Crystallography, X-Ray Humans Molecular Conformation Six previously undescribed spiromeroterpenoids, chermesins I-N (1-6), were isolated and identified from the marine-sourced fungus Penicillium chermesinum AS-400. Their structures were determined by nuclear magnetic resonance and mass spectroscopic data, and the relative and absolute configurations were confirmed based on nuclear Overhauser effect spectroscopic experiments, electronic circular dichroism (ECD) calculations and X-ray crystallographic analysis, and by comparisons of ECD Cotton effects with those of known congeners as well. Structurally, compound 1 represents the first example of spiromeroterpenoid demethylated at C-4. The isolated compounds exhibited inhibitory activities against several aquatic and human pathogenic bacteria with MIC values ranging from 4 to 64 μg/mL. |
| title | Chermesins I-N: Bioactive spiromeroterpenoids from the marine-sourced fungus Penicillium chermesinum AS-400. |
| topic | Penicillium Microbial Sensitivity Tests Molecular Structure Anti-Bacterial Agents Crystallography, X-Ray Humans Molecular Conformation |
| url | https://pubmed.ncbi.nlm.nih.gov/39755326/ |