The functional role of LncRNA HOXA-AS2 in multiple human cancers.
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| Format: | Artículo científico |
| Langue: | en |
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Pathology, research and practice
2025
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| author | Khoshandam, Mohadeseh Sideris, Nikolaos Ahmadieh-Yazdi, Amirhossein Sheykhhasan, Mohsen Manoochehri, Hamed Tanzadehpanah, Hamid Mahaki, Hanie Ghadam, Mona Lak, Shermin Kalhor, Naser Rabiei, Mohammad Al-Musawi, Sharafaldin Dama, Paola |
| author_facet | Khoshandam, Mohadeseh Sideris, Nikolaos Ahmadieh-Yazdi, Amirhossein Sheykhhasan, Mohsen Manoochehri, Hamed Tanzadehpanah, Hamid Mahaki, Hanie Ghadam, Mona Lak, Shermin Kalhor, Naser Rabiei, Mohammad Al-Musawi, Sharafaldin Dama, Paola Khoshandam, Mohadeseh Sideris, Nikolaos Ahmadieh-Yazdi, Amirhossein Sheykhhasan, Mohsen Manoochehri, Hamed Tanzadehpanah, Hamid Mahaki, Hanie Ghadam, Mona Lak, Shermin Kalhor, Naser Rabiei, Mohammad Al-Musawi, Sharafaldin Dama, Paola |
| collection | PubMed - marine biology |
| contents | The functional role of LncRNA HOXA-AS2 in multiple human cancers. Khoshandam, Mohadeseh Sideris, Nikolaos Ahmadieh-Yazdi, Amirhossein Sheykhhasan, Mohsen Manoochehri, Hamed Tanzadehpanah, Hamid Mahaki, Hanie Ghadam, Mona Lak, Shermin Kalhor, Naser Rabiei, Mohammad Al-Musawi, Sharafaldin Dama, Paola Humans RNA, Long Noncoding Neoplasms Proto-Oncogene Mas Gene Expression Regulation, Neoplastic Biomarkers, Tumor Epithelial-Mesenchymal Transition Cell Proliferation Humans have more than 270,000 lncRNAs. Among these, lncRNA HOXA-AS2 is considered a transformative gene involved in various cellular processes, including cell proliferation, apoptosis, migration, and invasion. Thus, it can be regarded as a potential tumor marker for both diagnosis and prognosis. Aberrant expression of lncRNAs is associated with many cancers, including hepatocellular carcinoma (HCC), gallbladder carcinoma (GBC), acute promyelocytic leukemia (APL), lung cancer (LC), prostate cancer (PC), osteosarcoma (OS), colorectal cancer (CRC), cervical cancer (CC), and acute myeloid leukemia (AML). Targeting lncRNAs could be a promising strategy to complement or replace current cancer treatments. As a non-coding oncogene, lncRNA HOXA-AS2 is implicated in multiple cancers and could serve as a potential biomarker for various malignancies. The tumor size and disease stage of several cancers are correlated with HOXA-AS2 expression. Silencing HOXA-AS2 effectively suppresses tumor cell proliferation and promotes apoptosis, thereby inhibiting the progression of multiple cancer types. The regulatory mechanisms of HOXA-AS2 include inducing epithelial-mesenchymal transition (EMT), overexpressing B-cell lymphoma-2 (Bcl-2) and MYC proto-oncogene (c-Myc), gene silencing, activating AKT-MMP signaling pathways, EZH2 and LSD1, and functioning within a competing endogenous RNA (ceRNA) regulatory network by competitively binding miRNAs. This review surveys recent research on the structure, biological functions, abnormal expression, regulatory mechanisms, and diagnostic and therapeutic potential of HOXA-AS2 in various cancers. |
| format | Artículo científico |
| id | pubmed_39756105 |
| institution | PubMed |
| language | en |
| publishDate | 2025 |
| publisher | Pathology, research and practice |
| record_format | pubmed |
| spellingShingle | The functional role of LncRNA HOXA-AS2 in multiple human cancers. Khoshandam, Mohadeseh Sideris, Nikolaos Ahmadieh-Yazdi, Amirhossein Sheykhhasan, Mohsen Manoochehri, Hamed Tanzadehpanah, Hamid Mahaki, Hanie Ghadam, Mona Lak, Shermin Kalhor, Naser Rabiei, Mohammad Al-Musawi, Sharafaldin Dama, Paola Humans RNA, Long Noncoding Neoplasms Proto-Oncogene Mas Gene Expression Regulation, Neoplastic Biomarkers, Tumor Epithelial-Mesenchymal Transition Cell Proliferation The functional role of LncRNA HOXA-AS2 in multiple human cancers. Khoshandam, Mohadeseh Sideris, Nikolaos Ahmadieh-Yazdi, Amirhossein Sheykhhasan, Mohsen Manoochehri, Hamed Tanzadehpanah, Hamid Mahaki, Hanie Ghadam, Mona Lak, Shermin Kalhor, Naser Rabiei, Mohammad Al-Musawi, Sharafaldin Dama, Paola Humans RNA, Long Noncoding Neoplasms Proto-Oncogene Mas Gene Expression Regulation, Neoplastic Biomarkers, Tumor Epithelial-Mesenchymal Transition Cell Proliferation Humans have more than 270,000 lncRNAs. Among these, lncRNA HOXA-AS2 is considered a transformative gene involved in various cellular processes, including cell proliferation, apoptosis, migration, and invasion. Thus, it can be regarded as a potential tumor marker for both diagnosis and prognosis. Aberrant expression of lncRNAs is associated with many cancers, including hepatocellular carcinoma (HCC), gallbladder carcinoma (GBC), acute promyelocytic leukemia (APL), lung cancer (LC), prostate cancer (PC), osteosarcoma (OS), colorectal cancer (CRC), cervical cancer (CC), and acute myeloid leukemia (AML). Targeting lncRNAs could be a promising strategy to complement or replace current cancer treatments. As a non-coding oncogene, lncRNA HOXA-AS2 is implicated in multiple cancers and could serve as a potential biomarker for various malignancies. The tumor size and disease stage of several cancers are correlated with HOXA-AS2 expression. Silencing HOXA-AS2 effectively suppresses tumor cell proliferation and promotes apoptosis, thereby inhibiting the progression of multiple cancer types. The regulatory mechanisms of HOXA-AS2 include inducing epithelial-mesenchymal transition (EMT), overexpressing B-cell lymphoma-2 (Bcl-2) and MYC proto-oncogene (c-Myc), gene silencing, activating AKT-MMP signaling pathways, EZH2 and LSD1, and functioning within a competing endogenous RNA (ceRNA) regulatory network by competitively binding miRNAs. This review surveys recent research on the structure, biological functions, abnormal expression, regulatory mechanisms, and diagnostic and therapeutic potential of HOXA-AS2 in various cancers. |
| title | The functional role of LncRNA HOXA-AS2 in multiple human cancers. |
| topic | Humans RNA, Long Noncoding Neoplasms Proto-Oncogene Mas Gene Expression Regulation, Neoplastic Biomarkers, Tumor Epithelial-Mesenchymal Transition Cell Proliferation |
| url | https://pubmed.ncbi.nlm.nih.gov/39756105/ |