DMSO-promoted α-bromination of α-aryl ketones for the construction of 2-aryl-2-bromo-cycloketones.
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PubMed
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| Autori principali: | , , , |
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| Natura: | Artículo científico |
| Lingua: | en |
| Pubblicazione: |
Organic & biomolecular chemistry
2025
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| _version_ | 1868266260610940929 |
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| author | Zhai, Haojiang Li, Penghui Wang, Hongshuang Wang, Xiaohui |
| author_facet | Zhai, Haojiang Li, Penghui Wang, Hongshuang Wang, Xiaohui Zhai, Haojiang Li, Penghui Wang, Hongshuang Wang, Xiaohui |
| collection | PubMed - marine biology |
| contents | DMSO-promoted α-bromination of α-aryl ketones for the construction of 2-aryl-2-bromo-cycloketones. Zhai, Haojiang Li, Penghui Wang, Hongshuang Wang, Xiaohui A DMSO-promoted practical one-step α-bromination reaction of α-aryl ketones with NBS has been developed for the construction of 2-aryl-2-bromo-cycloketones. The desired regioselective α-bromination products were isolated in moderate to good yields, with a maximum tested scale of 15 mmol. Notably, ketamine derivatives could be smoothly synthesized in two steps. |
| format | Artículo científico |
| id | pubmed_39760490 |
| institution | PubMed |
| language | en |
| publishDate | 2025 |
| publisher | Organic & biomolecular chemistry |
| record_format | pubmed |
| spellingShingle | DMSO-promoted α-bromination of α-aryl ketones for the construction of 2-aryl-2-bromo-cycloketones. Zhai, Haojiang Li, Penghui Wang, Hongshuang Wang, Xiaohui DMSO-promoted α-bromination of α-aryl ketones for the construction of 2-aryl-2-bromo-cycloketones. Zhai, Haojiang Li, Penghui Wang, Hongshuang Wang, Xiaohui A DMSO-promoted practical one-step α-bromination reaction of α-aryl ketones with NBS has been developed for the construction of 2-aryl-2-bromo-cycloketones. The desired regioselective α-bromination products were isolated in moderate to good yields, with a maximum tested scale of 15 mmol. Notably, ketamine derivatives could be smoothly synthesized in two steps. |
| title | DMSO-promoted α-bromination of α-aryl ketones for the construction of 2-aryl-2-bromo-cycloketones. |
| url | https://pubmed.ncbi.nlm.nih.gov/39760490/ |