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Main Authors:	Zhang, Wenfeng, Gong, Hui, Sun, Qianqian, Fu, Yuting, Wu, Xiaosi, Deng, Hengwei, Weng, Shaoping, He, Jianguo, Dong, Chuanfu
Format:	Artículo científico
Language:	en
Published:	Viruses 2024
Subjects:	Animals Ranavirus DNA Virus Infections B-Lymphocytes Fish Diseases Viral Load Persistent Infection Disease Reservoirs Fishes
Online Access:	https://pubmed.ncbi.nlm.nih.gov/39772201/
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Singapore grouper iridovirus VP12 evades the host antiviral immune response by targeting the cGAS-STING signalling pathway.
by: Zhang, Luhao, et al.
Published: (2024)

Antiviral activity of marine fungal polysaccharide AVP141-A against Singapore grouper iridovirus (SGIV) in vitro and in vivo.
by: Liao, Xinyu, et al.
Published: (2026)

Immune and protective effects of recombinant multi-epitopes vaccine against infectious spleen and kidney necrosis virus in pearl gentian grouper (♀Epinephelus fuscoguttatus × ♂Epinephelus lanceolatus).
by: Liu, Xinxin, et al.
Published: (2026)

Interferon regulatory factor 6 gene from Oreochromis niloticus is involved in resistance against tilapia lake virus.
by: Feng, Mingyang, et al.
Published: (2026)

Giant grouper nervous necrosis virus subgenomic RNA3 is transcribed by a premature termination mechanism via intragenomic RNA-RNA pairing.
by: Cheng, Chao-An, et al.
Published: (2025)

Comparative analysis of T-cell immunity between Streptococcus agalactiae susceptible and resistant tilapia (Oreochromis niloticus).
by: Zhang, Jiansong, et al.
Published: (2024)

The Ran GTPase inhibits SGIV and RGNNV infection by upregulating host immune response in grouper.
by: Wen, Xiaozhi, et al.
Published: (2025)

Grouper interleukin 15-like acts as a cytokine adjuvant in grouper iridovirus subunit vaccine.
by: Zheng, Jiaying, et al.
Published: (2025)

Development and evaluation of recombinant multi-epitopes vaccine against nervous necrosis virus.
by: Zhang, Chen, et al.
Published: (2025)

Isolation, Identification and Genomic Analysis of Orange-Spotted Grouper Iridovirus Hainan Strain in China.
by: Cao, Helong, et al.
Published: (2024)

Genomic organization of the TCRα locus and essential roles of αβ T cells in antibacterial immunity in Nile tilapia.
by: Geng, Ming, et al.
Published: (2026)

Rationally designed self-assembled peptide nanofibers provoke robust humoral immunity against nervous necrosis virus.
by: Zhang, Chen, et al.
Published: (2025)

Bacterial infection triggers CD3ε T cell expansion and interaction with macrophages in grass carp (Ctenopharyngodon idella).
by: Gao, Wa, et al.
Published: (2026)

Fish requires FasL to facilitate CD8+ T-cell function and antimicrobial immunity.
by: Li, Kang, et al.
Published: (2025)

Biopsy-based normalizations of gill monogenean-infected European catfish ( L., 1758) stocks for laboratory-based experiments.
by: Bognár, András, et al.
Published: (2024)

Comparing Genome Sequencing Methods to Reconstruct the Spread of Piscine Myocarditis Virus in Ireland.
by: Tighe, Andrew J, et al.
Published: (2025)

Co-infection of nervous necrosis virus and Vibrio harveyi increased mortality and worsened the disease severity in the orange-spotted grouper (Epinephelus coioides).
by: Guan, Lingfeng, et al.
Published: (2025)

pacsin1 inhibits antiviral immunity by promoting MITA degradation through autophagy in miiuy croaker, Miichthysmiiuy.
by: Li, Wenxin, et al.
Published: (2025)

CXCL20a promotes the immune protection of an inactivated vaccine against grass carp reovirus infection in grass carp (Ctenopharyngodon idella).
by: Lu, Yizhong, et al.
Published: (2026)

Establishment and characterization of a novel cell line from spleen of humpback grouper (Cromileptes altivelis) and its application in pathogens susceptibility.
by: Wei, Cao-Ying, et al.
Published: (2025)

Oral immunization with a DNA vaccine encoding capsid protein and IFN-γ provokes efficient and long-term immunity against nervous necrosis virus.
by: Peng, Haihua, et al.
Published: (2025)

Lambda carrageenan displays antiviral activity against the infectious pancreatic necrosis virus (IPNV) by inhibiting viral replication and enhancing innate immunity in salmonid cells.
by: Espinoza, Daniela, et al.
Published: (2024)

CD3γ/δ T cells and MCSFR macrophages are activated to produce IL-26 after bacterial infection in grass carp.
by: Xie, Teng, et al.
Published: (2025)

Dietary myo-inositol exerts pleiotropic effects on T cell activation, antioxidant defense and fatty acid metabolism to enhance anti-bacterial immunity in tilapia.
by: Fang, Zhichao, et al.
Published: (2026)

Gut T cell-microbiota crosstalk orchestrates antibacterial immunity and mucosal homeostasis in teleost.
by: Geng, Ming, et al.
Published: (2026)

Cold-blooded vertebrate utilizes behavioral fever to alleviate T cell apoptosis and optimize antimicrobial immunity.
by: Gao, Haiyou, et al.
Published: (2024)

Myosin light chain 3 serves as a receptor for nervous necrosis virus entry into host cells via the macropinocytosis pathway.
by: Yao, Lan, et al.
Published: (2025)

A vaccine combining ORF132 and ORF25 expressed by Saccharomyces cerevisiae induces protective immunity in Carassius auratus gibelio against CyHV-2.
by: Liang, Jiahui, et al.
Published: (2025)

Cd36 deficiency enhances the immune defence against Grass Carp Reovirus in zebrafish.
by: Gao, Jing, et al.
Published: (2025)

A modified IL-7 enhances the immune response to an inactivated GCRV-II vaccine in grass carp (Ctenopharyngodon idella).
by: Wang, Shijie, et al.
Published: (2026)

PTPN2 modulates antiviral immunity in grouper by promoting TBK1 degradation and suppressing interferon signaling.
by: Liao, Xinyu, et al.
Published: (2025)

Development of a High-Hydrostatic-Pressure-Treated Recombinant Vaccine Targeting the Major Capsid Protein of Red Sea Bream Iridovirus.
by: Sawasaki, Yuta, et al.
Published: (2026)

Molnupiravir: A Prodrug of the Ribonucleoside β-D-N4-Hydroxycytidine Triphosphate Inhibits the Propagation of Nervous Necrosis Virus in Grouper Brain Cells.
by: Chi, Chen-Kung, et al.
Published: (2026)

Transcriptomic analysis reveals the role of MAPK signaling pathway in IgM B cells against Pseudomonas plecoglossicida infection in large yellow croaker (Larimichthys crocea).
by: Zhu, Zhuo, et al.
Published: (2025)

Arachidonic acid reverses microplastic-induced macrophage dysfunction in teleost fish.
by: Cao, Yun-Chao, et al.
Published: (2026)

Two virulent Vibrio campbellii phages with potential for phage therapy in aquaculture.
by: Ding, Huiyu, et al.
Published: (2025)

Oral antiviral vaccines in aquaculture: Current status, challenges, and future prospects.
by: Rojas-Peña, M, et al.
Published: (2026)

Cyprinid herpesvirus 2 (CyHV-2) ORF67 inhibits IFN expression by competitively obstructing STING phosphorylation.
by: Cui, Bao-Jie, et al.
Published: (2025)

Autophagic degradation of MAVS-B by Carassius auratus herpesvirus (CaHV) ORF56 suppresses interferon response in polyploid gibel carp.
by: Zhou, Chu-Jing, et al.
Published: (2026)

if (filemtime($filename) + $maxlifetime < time()) { unlink($filename); $count++; } } return $count; } /** * A function that is called internally when session data is to be saved. * * @param string $sessId The current session ID * @param string $data The session data to write * * @return bool */ protected function saveSession($sessId, $data): bool { $sessFile = $this->path . '/sess_' . $sessId; if ($handle = fopen($sessFile, 'w')) { $return = false; // Lock the file for exclusive access to avoid issues with multiple // processes writing session simultaneously: if (flock($handle, LOCK_EX)) { $return = fwrite($handle, $data); // Make sure that there's no trailing data by truncating the file to // the correct length: ftruncate($handle, strlen($data)); fflush($handle); flock($handle, LOCK_UN); } fclose($handle); if ($return !== false) { return true; } } // If we got this far, something went wrong with the file output... // It is tempting to throw an exception here, but this code is called // outside of the context of exception handling, so all we can do is // echo a message.

// Anecdotal testing Today and Yesterday seems to indicate destroy() // is called by the garbage collector and everything is good. // Something to keep in mind though. return 0; } /** * Write function that is called when session data is to be saved. * * @param string $sessId The current session ID * @param string $data The session data to write * * @return bool */ public function write($sessId, $data): bool { if ($this->writesDisabled) { return true; } return $this->saveSession($sessId, $data); } /** * A function that is called internally when session data is to be saved. * * @param string $sessId The current session ID * @param string $data The session data to write * * @return bool */ abstract protected function saveSession($sessId, $data): bool; }

* * @return void */ public function writeClose() { // The assumption is that we're using PHP's ext/session. // session_write_close() will actually overwrite $_SESSION with an // empty array on completion -- which leads to a mismatch between what // is in the storage object and $_SESSION. To get around this, we // temporarily reset $_SESSION to an array, and then re-link it to // the storage object. // // Additionally, while you _can_ write to $_SESSION following a // session_write_close() operation, no changes made to it will be // flushed to the session handler. As such, we now mark the storage // object isImmutable. $storage = $this->getStorage(); if (! $storage->isImmutable()) { $_SESSION = $storage->toArray(true); session_write_close(); $storage->fromArray($_SESSION); $storage->markImmutable(); } } /** * Attempt to set the session name * * If the session has already been started, or if the name provided fails * validation, an exception will be raised. * * @param string $name * @return SessionManager * @throws Exception\InvalidArgumentException */ public function setName($name) { if ($this->sessionExists()) { throw new Exception\InvalidArgumentException( 'Cannot set session name after a session has already started'

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