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| Main Authors: | , , , , , , |
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| Format: | Artículo científico |
| Language: | en |
| Published: |
Nature communications
2025
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| Subjects: | |
| Online Access: | https://pubmed.ncbi.nlm.nih.gov/39809803/ |
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| _version_ | 1868266255331360768 |
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| author | Peng, Qiannan Zhao, Cheng Wang, Xiaopeng Cheng, Kelin Wang, Congcong Xu, Xihui Lin, Lu |
| author_facet | Peng, Qiannan Zhao, Cheng Wang, Xiaopeng Cheng, Kelin Wang, Congcong Xu, Xihui Lin, Lu Peng, Qiannan Zhao, Cheng Wang, Xiaopeng Cheng, Kelin Wang, Congcong Xu, Xihui Lin, Lu |
| collection | PubMed - marine biology |
| contents | Modeling bacterial interactions uncovers the importance of outliers in the coastal lignin-degrading consortium. Peng, Qiannan Zhao, Cheng Wang, Xiaopeng Cheng, Kelin Wang, Congcong Xu, Xihui Lin, Lu Lignin Microbial Consortia Bacteria Biodegradation, Environmental Seawater Lignin, as the abundant carbon polymer, is essential for carbon cycle and biorefinery. Microorganisms interact to form communities for lignin biodegradation, yet it is a challenge to understand such complex interactions. Here, we develop a coastal lignin-degrading bacterial consortium (LD), through "top-down" enrichment. Sequencing and physiological analyses reveal that LD is dominated by the lignin degrader Pluralibacter gergoviae (>98%), with additional rare non-degraders. Interestingly, LD, cultured in lignin-MB medium, significantly enhances cell growth and lignin degradation as compared to P. gergoviae alone, implying a role of additional outliers. Using genome-scale metabolic models, metabolic profiling and culture experiments, modeling of inter-species interactions between P. gergoviae, Vibrio alginolyticus, Aeromonas hydrophila and Shewanella putrefaciens, unravels cross-feeding of amino acids, organic acids and alcohols between the degrader and non-degraders. Furthermore, the sub-population ratio is essential to enforce the synergy. Our study highlights the unrecognized role of outliers in lignin degradation. |
| format | Artículo científico |
| id | pubmed_39809803 |
| institution | PubMed |
| language | en |
| publishDate | 2025 |
| publisher | Nature communications |
| record_format | pubmed |
| spellingShingle | Modeling bacterial interactions uncovers the importance of outliers in the coastal lignin-degrading consortium. Peng, Qiannan Zhao, Cheng Wang, Xiaopeng Cheng, Kelin Wang, Congcong Xu, Xihui Lin, Lu Lignin Microbial Consortia Bacteria Biodegradation, Environmental Seawater Modeling bacterial interactions uncovers the importance of outliers in the coastal lignin-degrading consortium. Peng, Qiannan Zhao, Cheng Wang, Xiaopeng Cheng, Kelin Wang, Congcong Xu, Xihui Lin, Lu Lignin Microbial Consortia Bacteria Biodegradation, Environmental Seawater Lignin, as the abundant carbon polymer, is essential for carbon cycle and biorefinery. Microorganisms interact to form communities for lignin biodegradation, yet it is a challenge to understand such complex interactions. Here, we develop a coastal lignin-degrading bacterial consortium (LD), through "top-down" enrichment. Sequencing and physiological analyses reveal that LD is dominated by the lignin degrader Pluralibacter gergoviae (>98%), with additional rare non-degraders. Interestingly, LD, cultured in lignin-MB medium, significantly enhances cell growth and lignin degradation as compared to P. gergoviae alone, implying a role of additional outliers. Using genome-scale metabolic models, metabolic profiling and culture experiments, modeling of inter-species interactions between P. gergoviae, Vibrio alginolyticus, Aeromonas hydrophila and Shewanella putrefaciens, unravels cross-feeding of amino acids, organic acids and alcohols between the degrader and non-degraders. Furthermore, the sub-population ratio is essential to enforce the synergy. Our study highlights the unrecognized role of outliers in lignin degradation. |
| title | Modeling bacterial interactions uncovers the importance of outliers in the coastal lignin-degrading consortium. |
| topic | Lignin Microbial Consortia Bacteria Biodegradation, Environmental Seawater |
| url | https://pubmed.ncbi.nlm.nih.gov/39809803/ |