Gespeichert in:
| Hauptverfasser: | , , , , , , |
|---|---|
| Format: | Artículo científico |
| Sprache: | en |
| Veröffentlicht: |
ChemMedChem
2025
|
| Schlagworte: | |
| Online-Zugang: | https://pubmed.ncbi.nlm.nih.gov/39821494/ |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
Inhaltsangabe:
- Tumor Microenvironment-Responsive Multinucleated Nanocomplexes Loaded with Carbon Dots for Combined Photothermal/Chemodynamic Therapy of Breast Cancer. Zhu, Zihan Zhang, Yan He, Cui Jin, Yimin Bian, Wei Tang, Xinjing Wang, Jing Carbon Tumor Microenvironment Humans Quantum Dots Animals Female Breast Neoplasms Antineoplastic Agents Mice Reactive Oxygen Species Photothermal Therapy Cell Proliferation Drug Screening Assays, Antitumor Cell Survival Mice, Inbred BALB C Particle Size Low cure rate and high death rate of cancers have seriously threatened human health. The combining multiple therapies is a promising strategy for cancer treatment. In this study, we construct a novel multinucleated nanocomplex loaded with carbon dots (CDs-SA@TAMn) that responds to tumor microenvironment for combined photothermal/chemodynamic cancer therapy. Fluorescence imaging results show that CDs-SA@TAMn can effectively accumulated in tumor sites. In acidic tumor microenvironment, CDs-SA@TAMn will release Mn, activating chemodynamic therapy and producing substantial reactive oxygen species (ROS) to kill tumor. Additionally, when irradiated by an 808 nm laser, CDs-SA@TAMn will exert the photothermal effect to realize high performance of cancer hyperthermia treatment. The nanocomplexes feather simple preparation, low toxicity, controlled release and imaging-guided therapy, showcasing the potential of precise and high-performance anti-tumor combination therapy in biomedical applications.