Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Artículo científico |
| Language: | en |
| Published: |
Fish & shellfish immunology
2025
|
| Subjects: | |
| Online Access: | https://pubmed.ncbi.nlm.nih.gov/39837401/ |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1868266252643860482 |
|---|---|
| author | Han, Xiu Feng Che, Ming Yue Su, Xue Tian, Jing Yun Liu, Lan Hao Nie, Pin Wang, Su |
| author_facet | Han, Xiu Feng Che, Ming Yue Su, Xue Tian, Jing Yun Liu, Lan Hao Nie, Pin Wang, Su Han, Xiu Feng Che, Ming Yue Su, Xue Tian, Jing Yun Liu, Lan Hao Nie, Pin Wang, Su |
| collection | PubMed - marine biology |
| contents | Molecular characterization of TRAF gene family in snakehead (Channa argus). Han, Xiu Feng Che, Ming Yue Su, Xue Tian, Jing Yun Liu, Lan Hao Nie, Pin Wang, Su Animals Fish Proteins Phylogeny Poly I-C Fish Diseases Fishes Sequence Alignment Tumor Necrosis Factor Receptor-Associated Peptides and Proteins Amino Acid Sequence Immunity, Innate Gene Expression Regulation Gene Expression Profiling Multigene Family Perciformes Tumor necrosis factor receptor-associated factors (TRAFs) act as signal transducers and are critical in many biological processes. However, in contrast to mammals, the function of TRAFs in teleost is still largely unknown. In this study, we identified and cloned eight TRAF genes in snakehead (Channa argus), namely CaTRAF2aa, CaTRAF2ab, CaTRAF2b, CaTRAF3, CaTRAF4a, CaTRAF5, CaTRAF6, and CaTRAF7. Bioinformatics analyses exhibited CaTRAF genes were evolutionarily conserved among teleost. Subcellular localization results demonstrated that eight CaTRAFs were all localized in cytoplasm. These CaTRAFs showed widespread but different expression profiles in various organs/tissues of snakehead and their expression could be induced by IHSV infection. Furthermore, almost all CaTRAFs can be impacted by poly (I:C) stimulation in HKLs. To sum up, this study provides a valuable foundation for further functional research on teleost TRAF genes. |
| format | Artículo científico |
| id | pubmed_39837401 |
| institution | PubMed |
| language | en |
| publishDate | 2025 |
| publisher | Fish & shellfish immunology |
| record_format | pubmed |
| spellingShingle | Molecular characterization of TRAF gene family in snakehead (Channa argus). Han, Xiu Feng Che, Ming Yue Su, Xue Tian, Jing Yun Liu, Lan Hao Nie, Pin Wang, Su Animals Fish Proteins Phylogeny Poly I-C Fish Diseases Fishes Sequence Alignment Tumor Necrosis Factor Receptor-Associated Peptides and Proteins Amino Acid Sequence Immunity, Innate Gene Expression Regulation Gene Expression Profiling Multigene Family Perciformes Molecular characterization of TRAF gene family in snakehead (Channa argus). Han, Xiu Feng Che, Ming Yue Su, Xue Tian, Jing Yun Liu, Lan Hao Nie, Pin Wang, Su Animals Fish Proteins Phylogeny Poly I-C Fish Diseases Fishes Sequence Alignment Tumor Necrosis Factor Receptor-Associated Peptides and Proteins Amino Acid Sequence Immunity, Innate Gene Expression Regulation Gene Expression Profiling Multigene Family Perciformes Tumor necrosis factor receptor-associated factors (TRAFs) act as signal transducers and are critical in many biological processes. However, in contrast to mammals, the function of TRAFs in teleost is still largely unknown. In this study, we identified and cloned eight TRAF genes in snakehead (Channa argus), namely CaTRAF2aa, CaTRAF2ab, CaTRAF2b, CaTRAF3, CaTRAF4a, CaTRAF5, CaTRAF6, and CaTRAF7. Bioinformatics analyses exhibited CaTRAF genes were evolutionarily conserved among teleost. Subcellular localization results demonstrated that eight CaTRAFs were all localized in cytoplasm. These CaTRAFs showed widespread but different expression profiles in various organs/tissues of snakehead and their expression could be induced by IHSV infection. Furthermore, almost all CaTRAFs can be impacted by poly (I:C) stimulation in HKLs. To sum up, this study provides a valuable foundation for further functional research on teleost TRAF genes. |
| title | Molecular characterization of TRAF gene family in snakehead (Channa argus). |
| topic | Animals Fish Proteins Phylogeny Poly I-C Fish Diseases Fishes Sequence Alignment Tumor Necrosis Factor Receptor-Associated Peptides and Proteins Amino Acid Sequence Immunity, Innate Gene Expression Regulation Gene Expression Profiling Multigene Family Perciformes |
| url | https://pubmed.ncbi.nlm.nih.gov/39837401/ |