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Main Authors:	Noor, Md Imran, Rahman, Md Saydur
Format:	Artículo científico
Language:	en
Published:	Environmental toxicology 2025
Subjects:	Animals Apoptosis Goldfish Oxidative Stress Kidney Cytochrome P-450 CYP1A1 Water Pollutants, Chemical Glycine Renin Glyphosate Herbicides Homeostasis Antioxidants
Online Access:	https://pubmed.ncbi.nlm.nih.gov/39853848/
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author	Noor, Md Imran Rahman, Md Saydur
author_facet	Noor, Md Imran Rahman, Md Saydur Noor, Md Imran Rahman, Md Saydur
collection	PubMed - marine biology
contents	Effects of Environmentally Relevant Concentrations of Roundup on Oxidative-Nitrative Stress, Cellular Apoptosis, Prooxidant-Antioxidant Homeostasis, Renin and CYP1A Expressions in Goldfish: Molecular Mechanisms Underlying Kidney Damage During Roundup Exposure. Noor, Md Imran Rahman, Md Saydur Animals Apoptosis Goldfish Oxidative Stress Kidney Cytochrome P-450 CYP1A1 Water Pollutants, Chemical Glycine Renin Glyphosate Herbicides Homeostasis Antioxidants Roundup is one of the most widely used glyphosate-based harmful herbicides in the United States as well as globally, which poses a severe risk for terrestrial and aquatic organisms. In order to identify the detrimental effects of Roundup exposure in aquatic organisms, we investigated the environmentally relevant concentrations of Roundup exposure (low dose: 0.5 μg/L and high dose: 5.0 μg/L for 2 weeks) on renin expression, oxidative-nitrative stress biomarkers (e.g., 2,4-dinitrophenol, DNP; and 3-nitrotyrosine protein, NTP), prooxidant-antioxidant enzymes expressions (e.g., superoxide dismutase, SOD; and catalase, CAT), cellular apoptosis, and cytochrome P450 1A (CYP1A) mRNA levels in the kidneys of goldfish ( Carassius auratus ). Histopathological and in situ TUNEL analyses showed widespread tissue disruption (e.g., bowman's capsule shrinkage, melanin pigment formation, etc.) and induced apoptotic nuclei in the kidneys of goldfish. Immunohistochemical and quantitative real-time PCR (qRT-PCR) analyses showed a significant (p
format	Artículo científico
id	pubmed_39853848
institution	PubMed
language	en
publishDate	2025
publisher	Environmental toxicology
record_format	pubmed
spellingShingle	Effects of Environmentally Relevant Concentrations of Roundup on Oxidative-Nitrative Stress, Cellular Apoptosis, Prooxidant-Antioxidant Homeostasis, Renin and CYP1A Expressions in Goldfish: Molecular Mechanisms Underlying Kidney Damage During Roundup Exposure. Noor, Md Imran Rahman, Md Saydur Animals Apoptosis Goldfish Oxidative Stress Kidney Cytochrome P-450 CYP1A1 Water Pollutants, Chemical Glycine Renin Glyphosate Herbicides Homeostasis Antioxidants Effects of Environmentally Relevant Concentrations of Roundup on Oxidative-Nitrative Stress, Cellular Apoptosis, Prooxidant-Antioxidant Homeostasis, Renin and CYP1A Expressions in Goldfish: Molecular Mechanisms Underlying Kidney Damage During Roundup Exposure. Noor, Md Imran Rahman, Md Saydur Animals Apoptosis Goldfish Oxidative Stress Kidney Cytochrome P-450 CYP1A1 Water Pollutants, Chemical Glycine Renin Glyphosate Herbicides Homeostasis Antioxidants Roundup is one of the most widely used glyphosate-based harmful herbicides in the United States as well as globally, which poses a severe risk for terrestrial and aquatic organisms. In order to identify the detrimental effects of Roundup exposure in aquatic organisms, we investigated the environmentally relevant concentrations of Roundup exposure (low dose: 0.5 μg/L and high dose: 5.0 μg/L for 2 weeks) on renin expression, oxidative-nitrative stress biomarkers (e.g., 2,4-dinitrophenol, DNP; and 3-nitrotyrosine protein, NTP), prooxidant-antioxidant enzymes expressions (e.g., superoxide dismutase, SOD; and catalase, CAT), cellular apoptosis, and cytochrome P450 1A (CYP1A) mRNA levels in the kidneys of goldfish ( Carassius auratus ). Histopathological and in situ TUNEL analyses showed widespread tissue disruption (e.g., bowman's capsule shrinkage, melanin pigment formation, etc.) and induced apoptotic nuclei in the kidneys of goldfish. Immunohistochemical and quantitative real-time PCR (qRT-PCR) analyses showed a significant (p
title	Effects of Environmentally Relevant Concentrations of Roundup on Oxidative-Nitrative Stress, Cellular Apoptosis, Prooxidant-Antioxidant Homeostasis, Renin and CYP1A Expressions in Goldfish: Molecular Mechanisms Underlying Kidney Damage During Roundup Exposure.
topic	Animals Apoptosis Goldfish Oxidative Stress Kidney Cytochrome P-450 CYP1A1 Water Pollutants, Chemical Glycine Renin Glyphosate Herbicides Homeostasis Antioxidants
url	https://pubmed.ncbi.nlm.nih.gov/39853848/

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