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| Autori principali: | , , , , , , , , |
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| Natura: | Artículo científico |
| Lingua: | en |
| Pubblicazione: |
Journal of bioscience and bioengineering
2025
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| Soggetti: | |
| Accesso online: | https://pubmed.ncbi.nlm.nih.gov/39864970/ |
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| _version_ | 1868266249927000064 |
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| author | Chen, Xueyi Dai, Wenli Liang, Wanqi Li, Dong Cai, Wo-Qi Zhang, Chan Hu, Wenlin Zhang, Bo-Bo Yang, Qiongqiong |
| author_facet | Chen, Xueyi Dai, Wenli Liang, Wanqi Li, Dong Cai, Wo-Qi Zhang, Chan Hu, Wenlin Zhang, Bo-Bo Yang, Qiongqiong Chen, Xueyi Dai, Wenli Liang, Wanqi Li, Dong Cai, Wo-Qi Zhang, Chan Hu, Wenlin Zhang, Bo-Bo Yang, Qiongqiong |
| collection | PubMed - marine biology |
| contents | ROS-responsive nanocarrier for oral delivery of monascin and enhanced alleviation of oxidative stress. Chen, Xueyi Dai, Wenli Liang, Wanqi Li, Dong Cai, Wo-Qi Zhang, Chan Hu, Wenlin Zhang, Bo-Bo Yang, Qiongqiong Oxidative Stress Reactive Oxygen Species Humans Administration, Oral Drug Carriers Heterocyclic Compounds, 3-Ring Nanoparticles Selenium Antioxidants Oxidative stress, caused by excessive production of reactive oxygen species (ROS), plays a crucial role in the occurrence and development of various diseases. Monascin can scavenge ROS and alleviate oxidative stress but with a low fermentation rate and bioavailability. Here, we optimized the fermentation process to increase the production of monascin (508.6 U/mL), and then systematically characterized its structure via HPLC, HPLC-MS, H NMR, and C NMR. Additionally, we innovatively modified carboxymethylcellulose sodium with selenium (CMC-Se) to encapsulate monascin (monascin@CMC-Se), which can sensitively respond to ROS and release monascin to effectively scavenge excessive ROS. Besides, the monascin@CMC-Se can significantly increase the bioaccessibility of monascin and alleviate cellular oxidative stress by enhancing its cellular uptake rate. Collectively, our work provides proof-of-principle evidence that the CMC-Se can precise delivery of monascin to an oxidatively stressed environment with high resistance to gastric fluids, laying a foundation to overcome inflammation-related diseases in the colon. |
| format | Artículo científico |
| id | pubmed_39864970 |
| institution | PubMed |
| language | en |
| publishDate | 2025 |
| publisher | Journal of bioscience and bioengineering |
| record_format | pubmed |
| spellingShingle | ROS-responsive nanocarrier for oral delivery of monascin and enhanced alleviation of oxidative stress. Chen, Xueyi Dai, Wenli Liang, Wanqi Li, Dong Cai, Wo-Qi Zhang, Chan Hu, Wenlin Zhang, Bo-Bo Yang, Qiongqiong Oxidative Stress Reactive Oxygen Species Humans Administration, Oral Drug Carriers Heterocyclic Compounds, 3-Ring Nanoparticles Selenium Antioxidants ROS-responsive nanocarrier for oral delivery of monascin and enhanced alleviation of oxidative stress. Chen, Xueyi Dai, Wenli Liang, Wanqi Li, Dong Cai, Wo-Qi Zhang, Chan Hu, Wenlin Zhang, Bo-Bo Yang, Qiongqiong Oxidative Stress Reactive Oxygen Species Humans Administration, Oral Drug Carriers Heterocyclic Compounds, 3-Ring Nanoparticles Selenium Antioxidants Oxidative stress, caused by excessive production of reactive oxygen species (ROS), plays a crucial role in the occurrence and development of various diseases. Monascin can scavenge ROS and alleviate oxidative stress but with a low fermentation rate and bioavailability. Here, we optimized the fermentation process to increase the production of monascin (508.6 U/mL), and then systematically characterized its structure via HPLC, HPLC-MS, H NMR, and C NMR. Additionally, we innovatively modified carboxymethylcellulose sodium with selenium (CMC-Se) to encapsulate monascin (monascin@CMC-Se), which can sensitively respond to ROS and release monascin to effectively scavenge excessive ROS. Besides, the monascin@CMC-Se can significantly increase the bioaccessibility of monascin and alleviate cellular oxidative stress by enhancing its cellular uptake rate. Collectively, our work provides proof-of-principle evidence that the CMC-Se can precise delivery of monascin to an oxidatively stressed environment with high resistance to gastric fluids, laying a foundation to overcome inflammation-related diseases in the colon. |
| title | ROS-responsive nanocarrier for oral delivery of monascin and enhanced alleviation of oxidative stress. |
| topic | Oxidative Stress Reactive Oxygen Species Humans Administration, Oral Drug Carriers Heterocyclic Compounds, 3-Ring Nanoparticles Selenium Antioxidants |
| url | https://pubmed.ncbi.nlm.nih.gov/39864970/ |