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| Main Authors: | , , , , , , , , |
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| Format: | Artículo científico |
| Language: | en |
| Published: |
Journal of bioscience and bioengineering
2025
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| Subjects: | |
| Online Access: | https://pubmed.ncbi.nlm.nih.gov/39864970/ |
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Table of Contents:
- ROS-responsive nanocarrier for oral delivery of monascin and enhanced alleviation of oxidative stress. Chen, Xueyi Dai, Wenli Liang, Wanqi Li, Dong Cai, Wo-Qi Zhang, Chan Hu, Wenlin Zhang, Bo-Bo Yang, Qiongqiong Oxidative Stress Reactive Oxygen Species Humans Administration, Oral Drug Carriers Heterocyclic Compounds, 3-Ring Nanoparticles Selenium Antioxidants Oxidative stress, caused by excessive production of reactive oxygen species (ROS), plays a crucial role in the occurrence and development of various diseases. Monascin can scavenge ROS and alleviate oxidative stress but with a low fermentation rate and bioavailability. Here, we optimized the fermentation process to increase the production of monascin (508.6 U/mL), and then systematically characterized its structure via HPLC, HPLC-MS, H NMR, and C NMR. Additionally, we innovatively modified carboxymethylcellulose sodium with selenium (CMC-Se) to encapsulate monascin (monascin@CMC-Se), which can sensitively respond to ROS and release monascin to effectively scavenge excessive ROS. Besides, the monascin@CMC-Se can significantly increase the bioaccessibility of monascin and alleviate cellular oxidative stress by enhancing its cellular uptake rate. Collectively, our work provides proof-of-principle evidence that the CMC-Se can precise delivery of monascin to an oxidatively stressed environment with high resistance to gastric fluids, laying a foundation to overcome inflammation-related diseases in the colon.