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| Autores principales: | , , , , , , |
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| Formato: | Artículo científico |
| Lenguaje: | en |
| Publicado: |
Journal of natural products
2025
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| Materias: | |
| Acceso en línea: | https://pubmed.ncbi.nlm.nih.gov/39883606/ |
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| _version_ | 1868266249884008449 |
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| author | Maharjan, Sailesh Isaksson, Johan Mattias Krupova, Monika Rämä, Teppo Hansen, Kine Østnes Hammer Andersen, Jeanette Hansen, Espen Holst |
| author_facet | Maharjan, Sailesh Isaksson, Johan Mattias Krupova, Monika Rämä, Teppo Hansen, Kine Østnes Hammer Andersen, Jeanette Hansen, Espen Holst Maharjan, Sailesh Isaksson, Johan Mattias Krupova, Monika Rämä, Teppo Hansen, Kine Østnes Hammer Andersen, Jeanette Hansen, Espen Holst |
| collection | PubMed - marine biology |
| contents | Metabolomics-Guided Discovery of Bipolarolides H-O, New Ophiobolin-Type Sesterterpenes with Antibacterial Activity from the Marine-Derived Fungus sp. nov. Maharjan, Sailesh Isaksson, Johan Mattias Krupova, Monika Rämä, Teppo Hansen, Kine Østnes Hammer Andersen, Jeanette Hansen, Espen Holst Sesterterpenes Anti-Bacterial Agents Molecular Structure Metabolomics Microbial Sensitivity Tests Ascomycota Streptococcus agalactiae Marine Biology A marine-derived Pleosporales fungus, , was isolated from driftwood and described as a new species. The fungus was cultivated in liquid media and a molecular networking-driven approach was used to identify potential new secondary metabolites. The targeted compounds were isolated using preparative HPLC-MS, and through extensive spectroscopic analysis, eight new ophiobolin-type sesterterpenes, bipolarolides H-O (-), were identified. The absolute configurations of the compounds were determined by ECD assessment. Bipolarolide L (), M (), and O () exhibited inhibitory activity against with MIC values of 86, 66, and 64 μM, respectively. |
| format | Artículo científico |
| id | pubmed_39883606 |
| institution | PubMed |
| language | en |
| publishDate | 2025 |
| publisher | Journal of natural products |
| record_format | pubmed |
| spellingShingle | Metabolomics-Guided Discovery of Bipolarolides H-O, New Ophiobolin-Type Sesterterpenes with Antibacterial Activity from the Marine-Derived Fungus sp. nov. Maharjan, Sailesh Isaksson, Johan Mattias Krupova, Monika Rämä, Teppo Hansen, Kine Østnes Hammer Andersen, Jeanette Hansen, Espen Holst Sesterterpenes Anti-Bacterial Agents Molecular Structure Metabolomics Microbial Sensitivity Tests Ascomycota Streptococcus agalactiae Marine Biology Metabolomics-Guided Discovery of Bipolarolides H-O, New Ophiobolin-Type Sesterterpenes with Antibacterial Activity from the Marine-Derived Fungus sp. nov. Maharjan, Sailesh Isaksson, Johan Mattias Krupova, Monika Rämä, Teppo Hansen, Kine Østnes Hammer Andersen, Jeanette Hansen, Espen Holst Sesterterpenes Anti-Bacterial Agents Molecular Structure Metabolomics Microbial Sensitivity Tests Ascomycota Streptococcus agalactiae Marine Biology A marine-derived Pleosporales fungus, , was isolated from driftwood and described as a new species. The fungus was cultivated in liquid media and a molecular networking-driven approach was used to identify potential new secondary metabolites. The targeted compounds were isolated using preparative HPLC-MS, and through extensive spectroscopic analysis, eight new ophiobolin-type sesterterpenes, bipolarolides H-O (-), were identified. The absolute configurations of the compounds were determined by ECD assessment. Bipolarolide L (), M (), and O () exhibited inhibitory activity against with MIC values of 86, 66, and 64 μM, respectively. |
| title | Metabolomics-Guided Discovery of Bipolarolides H-O, New Ophiobolin-Type Sesterterpenes with Antibacterial Activity from the Marine-Derived Fungus sp. nov. |
| topic | Sesterterpenes Anti-Bacterial Agents Molecular Structure Metabolomics Microbial Sensitivity Tests Ascomycota Streptococcus agalactiae Marine Biology |
| url | https://pubmed.ncbi.nlm.nih.gov/39883606/ |