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| Hauptverfasser: | , , , , , , |
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| Format: | Artículo científico |
| Sprache: | en |
| Veröffentlicht: |
Journal of natural products
2025
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| Schlagworte: | |
| Online-Zugang: | https://pubmed.ncbi.nlm.nih.gov/39883606/ |
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Inhaltsangabe:
- Metabolomics-Guided Discovery of Bipolarolides H-O, New Ophiobolin-Type Sesterterpenes with Antibacterial Activity from the Marine-Derived Fungus sp. nov. Maharjan, Sailesh Isaksson, Johan Mattias Krupova, Monika Rämä, Teppo Hansen, Kine Østnes Hammer Andersen, Jeanette Hansen, Espen Holst Sesterterpenes Anti-Bacterial Agents Molecular Structure Metabolomics Microbial Sensitivity Tests Ascomycota Streptococcus agalactiae Marine Biology A marine-derived Pleosporales fungus, , was isolated from driftwood and described as a new species. The fungus was cultivated in liquid media and a molecular networking-driven approach was used to identify potential new secondary metabolites. The targeted compounds were isolated using preparative HPLC-MS, and through extensive spectroscopic analysis, eight new ophiobolin-type sesterterpenes, bipolarolides H-O (-), were identified. The absolute configurations of the compounds were determined by ECD assessment. Bipolarolide L (), M (), and O () exhibited inhibitory activity against with MIC values of 86, 66, and 64 μM, respectively.