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| Main Authors: | , , |
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| Format: | Artículo científico |
| Language: | en |
| Published: |
EMBO reports
2025
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| Subjects: | |
| Online Access: | https://pubmed.ncbi.nlm.nih.gov/39885293/ |
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Table of Contents:
- PIF/harbinger transposon-derived protein promotes 7SL expression to enhance pathogen resistance. Geng, Shang Lv, Xing Xu, Tianjun DNA Transposable Elements Arabidopsis Proteins Arabidopsis Gene Expression Regulation, Plant Disease Resistance Histone Acetyltransferases Protein Binding Transcriptional regulation governs gene expression levels, primarily controlled by "cis-acting DNA elements" and "trans-acting protein factors". However, the conventional view that cis-regulation is solely attributable to DNA elements is challenged in this study. Our research indicates that transposon-derived proteins may retain their original DNA-binding preference and exert cis-regulatory effects on nearby genes on the chromosome, thus denoted as "cis-acting factors". Specifically, we show that the ADF-1L protein, derived from the PIF/harbinger transposon, recruits the histone acetyltransferase KAT2B in a MADF domain-dependent manner, facilitating its own nuclear translocation and binding to and cis-regulating its own and adjacent gene 7SL-23. ADF-1L protein also boosts the host's resistance to pathogens by promoting the expression of immune molecule 7SL RNA. In summary, our findings expand the types of molecules that can exert cis-function in gene regulation and underscore the relevance of transposons-derived sequences in cellular processes.