3-Furoic Acid from Sea-Derived Hy-6 as a Valuable Lead Compound against Plant-Parasitic Nematodes in Cucumber.
Fuente:
PubMed
Guardado en:
| Autores principales: | , , , , |
|---|---|
| Formato: | Artículo científico |
| Lenguaje: | en |
| Publicado: |
Journal of agricultural and food chemistry
2025
|
| Materias: | |
| Acceso en línea: | |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| _version_ | 1868266247462846464 |
|---|---|
| author | Wang, Linsong Gao, Kun Wang, Zhongwei Fan, Zhaoqian Qin, Yukun |
| author_facet | Wang, Linsong Gao, Kun Wang, Zhongwei Fan, Zhaoqian Qin, Yukun Wang, Linsong Gao, Kun Wang, Zhongwei Fan, Zhaoqian Qin, Yukun |
| collection | PubMed - marine biology |
| contents | 3-Furoic Acid from Sea-Derived Hy-6 as a Valuable Lead Compound against Plant-Parasitic Nematodes in Cucumber. Wang, Linsong Gao, Kun Wang, Zhongwei Fan, Zhaoqian Qin, Yukun Animals Cucumis sativus Antinematodal Agents Tylenchoidea Aspergillus Plant Diseases Furans Root-knot nematodes pose a significant threat to crop growth and yield, thereby impacting global food security. Here, the sea-derived hy-6 was identified as a producer of 3-furoic acid by liquid chromatography-mass spectrometry. Low doses of 3-furoic acid, an acidic compound with strong nematicidal activity, can reduce the motility, lifespan, and egg hatchability of nematodes in a dose-dependent manner. Additionally, 3-furoic acid was found to affect the chemotaxis of toward cucumber by decreasing the root's attractive activity to the nematodes. Metabolomic analyses indicated that the functional abnormalities in lipid metabolism may represent a critical molecular mechanism underlying severe metabolic dysfunction. Importantly, a significant enhancement in control efficacy was achieved through a simple structural modification, particularly with pent-4-en-1-yl furan-3-carboxylate (A1), which was superior to that of 3-furoic acid. These findings validated the potential of 3-furoic acid as a promising lead in the development of eco-friendly nematicides. |
| format | Artículo científico |
| id | pubmed_39886916 |
| institution | PubMed |
| language | en |
| publishDate | 2025 |
| publisher | Journal of agricultural and food chemistry |
| record_format | pubmed |
| spellingShingle | 3-Furoic Acid from Sea-Derived Hy-6 as a Valuable Lead Compound against Plant-Parasitic Nematodes in Cucumber. Wang, Linsong Gao, Kun Wang, Zhongwei Fan, Zhaoqian Qin, Yukun Animals Cucumis sativus Antinematodal Agents Tylenchoidea Aspergillus Plant Diseases Furans 3-Furoic Acid from Sea-Derived Hy-6 as a Valuable Lead Compound against Plant-Parasitic Nematodes in Cucumber. Wang, Linsong Gao, Kun Wang, Zhongwei Fan, Zhaoqian Qin, Yukun Animals Cucumis sativus Antinematodal Agents Tylenchoidea Aspergillus Plant Diseases Furans Root-knot nematodes pose a significant threat to crop growth and yield, thereby impacting global food security. Here, the sea-derived hy-6 was identified as a producer of 3-furoic acid by liquid chromatography-mass spectrometry. Low doses of 3-furoic acid, an acidic compound with strong nematicidal activity, can reduce the motility, lifespan, and egg hatchability of nematodes in a dose-dependent manner. Additionally, 3-furoic acid was found to affect the chemotaxis of toward cucumber by decreasing the root's attractive activity to the nematodes. Metabolomic analyses indicated that the functional abnormalities in lipid metabolism may represent a critical molecular mechanism underlying severe metabolic dysfunction. Importantly, a significant enhancement in control efficacy was achieved through a simple structural modification, particularly with pent-4-en-1-yl furan-3-carboxylate (A1), which was superior to that of 3-furoic acid. These findings validated the potential of 3-furoic acid as a promising lead in the development of eco-friendly nematicides. |
| title | 3-Furoic Acid from Sea-Derived Hy-6 as a Valuable Lead Compound against Plant-Parasitic Nematodes in Cucumber. |
| topic | Animals Cucumis sativus Antinematodal Agents Tylenchoidea Aspergillus Plant Diseases Furans |
| url | https://pubmed.ncbi.nlm.nih.gov/39886916/ |