The Mutually Inspiring Biological and Chemical Synthesis of Fungal Bicyclo[2.2.2]diazaoctane Indole Alkaloids.
Fuente:
PubMed
Salvato in:
| Autori principali: | , , , , , , |
|---|---|
| Natura: | Artículo científico |
| Lingua: | en |
| Pubblicazione: |
Chemical reviews
2025
|
| Soggetti: | |
| Accesso online: | |
| Tags: |
Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne!!
|
| _version_ | 1868266244717674498 |
|---|---|
| author | Du, Lei Dian, Longyang Newmister, Sean A Xia, Yuwei Luo, Guanzhong Sherman, David H Li, Shengying |
| author_facet | Du, Lei Dian, Longyang Newmister, Sean A Xia, Yuwei Luo, Guanzhong Sherman, David H Li, Shengying Du, Lei Dian, Longyang Newmister, Sean A Xia, Yuwei Luo, Guanzhong Sherman, David H Li, Shengying |
| collection | PubMed - marine biology |
| contents | The Mutually Inspiring Biological and Chemical Synthesis of Fungal Bicyclo[2.2.2]diazaoctane Indole Alkaloids. Du, Lei Dian, Longyang Newmister, Sean A Xia, Yuwei Luo, Guanzhong Sherman, David H Li, Shengying Indole Alkaloids Fungi Biological Products Fungal indole alkaloids bearing a bicyclo[2.2.2]diazaoctane (BCDO) core structure are a fascinating family of natural products that exhibit a wide spectrum of biological activities. These compounds also display remarkable structural diversity, with many different diastereomers and enantiomers produced by specific fungal strains. The biogenesis of the unique BCDO moiety has long been proposed to involve an intramolecular [4+2] -Diels-Alder (IMDA) reaction, but the exact mechanisms for this hypothetical transformation have remained elusive until recently. This review aims to summarize the whole history of synthetic and biosynthetic studies of fungal BCDO indole alkaloids, by covering the discovery, biomimetic syntheses, total syntheses, biosynthetic pathway elucidation, and biological activities of representative compounds. We highlight the mutual inspiration and corroboration between biological and synthetic chemists in exploring the intriguing biosynthetic mysteries of this family of natural products. We also provide perspectives and clues for the remaining biosynthetic problems. |
| format | Artículo científico |
| id | pubmed_39927617 |
| institution | PubMed |
| language | en |
| publishDate | 2025 |
| publisher | Chemical reviews |
| record_format | pubmed |
| spellingShingle | The Mutually Inspiring Biological and Chemical Synthesis of Fungal Bicyclo[2.2.2]diazaoctane Indole Alkaloids. Du, Lei Dian, Longyang Newmister, Sean A Xia, Yuwei Luo, Guanzhong Sherman, David H Li, Shengying Indole Alkaloids Fungi Biological Products The Mutually Inspiring Biological and Chemical Synthesis of Fungal Bicyclo[2.2.2]diazaoctane Indole Alkaloids. Du, Lei Dian, Longyang Newmister, Sean A Xia, Yuwei Luo, Guanzhong Sherman, David H Li, Shengying Indole Alkaloids Fungi Biological Products Fungal indole alkaloids bearing a bicyclo[2.2.2]diazaoctane (BCDO) core structure are a fascinating family of natural products that exhibit a wide spectrum of biological activities. These compounds also display remarkable structural diversity, with many different diastereomers and enantiomers produced by specific fungal strains. The biogenesis of the unique BCDO moiety has long been proposed to involve an intramolecular [4+2] -Diels-Alder (IMDA) reaction, but the exact mechanisms for this hypothetical transformation have remained elusive until recently. This review aims to summarize the whole history of synthetic and biosynthetic studies of fungal BCDO indole alkaloids, by covering the discovery, biomimetic syntheses, total syntheses, biosynthetic pathway elucidation, and biological activities of representative compounds. We highlight the mutual inspiration and corroboration between biological and synthetic chemists in exploring the intriguing biosynthetic mysteries of this family of natural products. We also provide perspectives and clues for the remaining biosynthetic problems. |
| title | The Mutually Inspiring Biological and Chemical Synthesis of Fungal Bicyclo[2.2.2]diazaoctane Indole Alkaloids. |
| topic | Indole Alkaloids Fungi Biological Products |
| url | https://pubmed.ncbi.nlm.nih.gov/39927617/ |