The mutation atlas of giant kelp (): a mutation database resource for natural knockouts.
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| Main Authors: | , , |
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| Format: | Artículo científico |
| Language: | en |
| Published: |
Frontiers in plant science
2024
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| _version_ | 1868266244715577344 |
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| author | Diesel, Jose Francisco Molano, Gary Nuzhdin, Sergey V |
| author_facet | Diesel, Jose Francisco Molano, Gary Nuzhdin, Sergey V Diesel, Jose Francisco Molano, Gary Nuzhdin, Sergey V |
| collection | PubMed - marine biology |
| contents | The mutation atlas of giant kelp (): a mutation database resource for natural knockouts. Diesel, Jose Francisco Molano, Gary Nuzhdin, Sergey V Giant kelp () is a paramount species of immense ecological and economic importance. It forms dense underwater forests, providing crucial habitat and serving as a foundation species for diverse marine ecosystems. Understanding the genetics of giant kelp is essential for conservation and sustainable farming, safeguarding these valuable ecosystems and their benefits. By analyzing mutations based on their impact, we can gain insights into the potential functional consequences and implications for the organism, helping to identify critical genes or regions that may play a significant role in adaptation, development, and environmental response. To achieve this, we annotated the effects and impact of spontaneous mutations in 559 giant kelp individuals from four different populations. We found over 15.9 million mutations in genes of giant kelp, and classified them into modifier, low, moderate, and high impact depending on their predicted effects. The creation of this mutation effect database, attached to the seedbank of these individuals, offers several applications, including enhancing breeding programs, aiding genetic engineering with naturally occurring mutations, and developing strategies to mitigate the impact of environmental changes. |
| format | Artículo científico |
| id | pubmed_39931339 |
| institution | PubMed |
| language | en |
| publishDate | 2024 |
| publisher | Frontiers in plant science |
| record_format | pubmed |
| spellingShingle | The mutation atlas of giant kelp (): a mutation database resource for natural knockouts. Diesel, Jose Francisco Molano, Gary Nuzhdin, Sergey V The mutation atlas of giant kelp (): a mutation database resource for natural knockouts. Diesel, Jose Francisco Molano, Gary Nuzhdin, Sergey V Giant kelp () is a paramount species of immense ecological and economic importance. It forms dense underwater forests, providing crucial habitat and serving as a foundation species for diverse marine ecosystems. Understanding the genetics of giant kelp is essential for conservation and sustainable farming, safeguarding these valuable ecosystems and their benefits. By analyzing mutations based on their impact, we can gain insights into the potential functional consequences and implications for the organism, helping to identify critical genes or regions that may play a significant role in adaptation, development, and environmental response. To achieve this, we annotated the effects and impact of spontaneous mutations in 559 giant kelp individuals from four different populations. We found over 15.9 million mutations in genes of giant kelp, and classified them into modifier, low, moderate, and high impact depending on their predicted effects. The creation of this mutation effect database, attached to the seedbank of these individuals, offers several applications, including enhancing breeding programs, aiding genetic engineering with naturally occurring mutations, and developing strategies to mitigate the impact of environmental changes. |
| title | The mutation atlas of giant kelp (): a mutation database resource for natural knockouts. |
| url | https://pubmed.ncbi.nlm.nih.gov/39931339/ |