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| Main Authors: | , , , , , |
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| Format: | Artículo científico |
| Language: | en |
| Published: |
RSC advances
2025
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| Online Access: | https://pubmed.ncbi.nlm.nih.gov/39944788/ |
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| _version_ | 1868266244697751553 |
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| author | Lai, Kuei-Hung Chung, Hsiao-Ling Chen, You-Ying Zheng, Li-Guo Su, Jui-Hsin El-Shazly, Mohamed |
| author_facet | Lai, Kuei-Hung Chung, Hsiao-Ling Chen, You-Ying Zheng, Li-Guo Su, Jui-Hsin El-Shazly, Mohamed Lai, Kuei-Hung Chung, Hsiao-Ling Chen, You-Ying Zheng, Li-Guo Su, Jui-Hsin El-Shazly, Mohamed |
| collection | PubMed - marine biology |
| contents | Insights into the structural diversity of cembranoids from and their bioactivity. Lai, Kuei-Hung Chung, Hsiao-Ling Chen, You-Ying Zheng, Li-Guo Su, Jui-Hsin El-Shazly, Mohamed Three capnosane-based cembranoids (1-3), four normal cembranoids (4-7), and one sarsolenane-based cembranoid (8) were isolated from the soft coral , including three new compounds: glacunoids A (1), B (4), and C (7). The chemical structures were elucidated using IR, MS, and NMR spectroscopy, with the absolute configurations of 1, 2, and 6 confirmed by single-crystal X-ray diffraction analysis. The bioactivity of the isolated compounds was evaluated for their effects on alkaline phosphatase (ALP) activity. All compounds demonstrated the ability to enhance ALP activity, with compound 8 exhibiting the most potent effect, achieving an ALP activity of 139.41 ± 8.06% without detectable cytotoxicity. This study represents the first report of three distinct structural types of cembranoids from a single soft coral species. |
| format | Artículo científico |
| id | pubmed_39944788 |
| institution | PubMed |
| language | en |
| publishDate | 2025 |
| publisher | RSC advances |
| record_format | pubmed |
| spellingShingle | Insights into the structural diversity of cembranoids from and their bioactivity. Lai, Kuei-Hung Chung, Hsiao-Ling Chen, You-Ying Zheng, Li-Guo Su, Jui-Hsin El-Shazly, Mohamed Insights into the structural diversity of cembranoids from and their bioactivity. Lai, Kuei-Hung Chung, Hsiao-Ling Chen, You-Ying Zheng, Li-Guo Su, Jui-Hsin El-Shazly, Mohamed Three capnosane-based cembranoids (1-3), four normal cembranoids (4-7), and one sarsolenane-based cembranoid (8) were isolated from the soft coral , including three new compounds: glacunoids A (1), B (4), and C (7). The chemical structures were elucidated using IR, MS, and NMR spectroscopy, with the absolute configurations of 1, 2, and 6 confirmed by single-crystal X-ray diffraction analysis. The bioactivity of the isolated compounds was evaluated for their effects on alkaline phosphatase (ALP) activity. All compounds demonstrated the ability to enhance ALP activity, with compound 8 exhibiting the most potent effect, achieving an ALP activity of 139.41 ± 8.06% without detectable cytotoxicity. This study represents the first report of three distinct structural types of cembranoids from a single soft coral species. |
| title | Insights into the structural diversity of cembranoids from and their bioactivity. |
| url | https://pubmed.ncbi.nlm.nih.gov/39944788/ |