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| Natura: | Artículo científico |
| Lingua: | en |
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Developmental and comparative immunology
2025
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| Soggetti: | |
| Accesso online: | https://pubmed.ncbi.nlm.nih.gov/39947504/ |
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| _version_ | 1868266242358378496 |
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| author | Deng, Yu Hang Li, Bo Chen, Shan Nan Li, Jia Yi Liu, Lan Hao Liu, Yang Nie, P |
| author_facet | Deng, Yu Hang Li, Bo Chen, Shan Nan Li, Jia Yi Liu, Lan Hao Liu, Yang Nie, P Deng, Yu Hang Li, Bo Chen, Shan Nan Li, Jia Yi Liu, Lan Hao Liu, Yang Nie, P |
| collection | PubMed - marine biology |
| contents | Types I to IV IFNs and their receptors in white spotted bamboo shark (Chiloscyllium plagiosum). Deng, Yu Hang Li, Bo Chen, Shan Nan Li, Jia Yi Liu, Lan Hao Liu, Yang Nie, P Animals Sharks Fish Proteins Poly I-C Receptors, Interferon Interferons Phylogeny Interferon Type I Interferons (IFNs) are a class of proteins with significant antiviral and antibacterial functions. To date, four distinct types of IFNs have been identified in vertebrates, including types I, II, III and IV IFNs. However, all these IFNs have not been reported together from any species of cartilaginous fish. In this study, types I, II, III and IV IFNs have been identified in white spotted bamboo shark (Chiloscyllium plagiosum). Type I IFNs were distributed in a conserved locus as reported in amphibian and zebrafish with seven duplicated genes. IFN-γ and IFN-υ genes were located in conserved loci as reported in other vertebrates, but four copies of IFN-υ genes were found in the bamboo shark as compared with a single gene in other vertebrates. However, a single IFN-λ gene was found in the bamboo shark, but not in the conserved gene locus as reported in other vertebrates. It is obvious that all these IFN genes were constitutively expressed in examined organs/tissue, and were induced following poly(I:C) stimulation. The findings of four types of IFNs in bamboo shark fill up the gap in relation with the composition of IFNs in cartilaginous fish, and contributes to the understanding of IFN system from an evolutionary point of view. |
| format | Artículo científico |
| id | pubmed_39947504 |
| institution | PubMed |
| language | en |
| publishDate | 2025 |
| publisher | Developmental and comparative immunology |
| record_format | pubmed |
| spellingShingle | Types I to IV IFNs and their receptors in white spotted bamboo shark (Chiloscyllium plagiosum). Deng, Yu Hang Li, Bo Chen, Shan Nan Li, Jia Yi Liu, Lan Hao Liu, Yang Nie, P Animals Sharks Fish Proteins Poly I-C Receptors, Interferon Interferons Phylogeny Interferon Type I Types I to IV IFNs and their receptors in white spotted bamboo shark (Chiloscyllium plagiosum). Deng, Yu Hang Li, Bo Chen, Shan Nan Li, Jia Yi Liu, Lan Hao Liu, Yang Nie, P Animals Sharks Fish Proteins Poly I-C Receptors, Interferon Interferons Phylogeny Interferon Type I Interferons (IFNs) are a class of proteins with significant antiviral and antibacterial functions. To date, four distinct types of IFNs have been identified in vertebrates, including types I, II, III and IV IFNs. However, all these IFNs have not been reported together from any species of cartilaginous fish. In this study, types I, II, III and IV IFNs have been identified in white spotted bamboo shark (Chiloscyllium plagiosum). Type I IFNs were distributed in a conserved locus as reported in amphibian and zebrafish with seven duplicated genes. IFN-γ and IFN-υ genes were located in conserved loci as reported in other vertebrates, but four copies of IFN-υ genes were found in the bamboo shark as compared with a single gene in other vertebrates. However, a single IFN-λ gene was found in the bamboo shark, but not in the conserved gene locus as reported in other vertebrates. It is obvious that all these IFN genes were constitutively expressed in examined organs/tissue, and were induced following poly(I:C) stimulation. The findings of four types of IFNs in bamboo shark fill up the gap in relation with the composition of IFNs in cartilaginous fish, and contributes to the understanding of IFN system from an evolutionary point of view. |
| title | Types I to IV IFNs and their receptors in white spotted bamboo shark (Chiloscyllium plagiosum). |
| topic | Animals Sharks Fish Proteins Poly I-C Receptors, Interferon Interferons Phylogeny Interferon Type I |
| url | https://pubmed.ncbi.nlm.nih.gov/39947504/ |